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Maggie Clapp Sullivan

@mclapps.bsky.social
507 followers 191 following 23 posts

WashU Postdoc with a UT PhD. Using multivariate genetic methods to study personality, cog aging, and substance use.

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Maggie Clapp Sullivan @mclapps.bsky.social · 14/09/2026
Our new work exploring associations between childhood thoughts, feelings, and behaviors and the big 5 personality PGIs is now preprinted! www.medrxiv.org/content/10.6...
medrxiv.org
Childhood Correlates of Genetic Propensity to Personality Traits
The Big 5 personality traits (extraversion, agreeableness, conscientiousness, neuroticism, openness to experience) are moderately heritable correlates of behavior, health, and life outcomes. Character...
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Luca Sclisizzo @luca-sclisizzo.bsky.social · 14/09/2026
🚨 New Preprint out! What if psychosis is not a single, homogeneous construct? "Parsing the functional heterogeneity of psychosis spectrum" addresses this question defining a genetic gradient across the spectrum. 🧬 www.medrxiv.org/content/10.6...
medrxiv.org
Parsing the Functional Heterogeneity of the Psychosis Spectrum: A Clinically Informed Application of Genomic Structural Equation Modeling
Schizophrenia, bipolar disorder, and major depression vary in their age of onset, cognitive impacts, degree of impairment, and clinical course. However, since psychosis is a transdiagnostic feature th...
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Maggie Clapp Sullivan @mclapps.bsky.social · 09/09/2026
Out today with @tedmond.bsky.social, our research briefing summarizing key takeaways from our Big Five GWAS! www.nature.com/articles/d41...
nature.com
Genetic associations with the Big Five personality traits probed in one million people
Links between genetic variants and personality differences are robust, complex and related to health, career and relationship outcomes.
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Ted Schwaba @tedmond.bsky.social · 04/09/2026
Some coverage of our Big Five GWAS! (with quotes by @tuckerdrob.bsky.social) After reading the comments section I am now in favor of compulsory psychometrics education.
nytimes.com
Scientists Find More Than 1,000 DNA Variants Linked to Personality Traits (Gift Article)
More than one million genomes helped identify DNA variants linked to extroversion, agreeableness, neuroticism and more. Researchers measured how those traits influenced how people lived.
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Michel Nivard @michelnivard.bsky.social · 02/09/2026
🚨& 🧵 Our new Nature paper is out! Across 46 cohorts and up to 1.14M people per Big Five trait, we do GWAS and ask how robust, generalizable and consequential the genetic signals underlying personality really are. www.nature.com/articles/s41...
nature.com
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Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 18/08/2026
Studies RFK Jr canceled: -Training rural healthcare workers to better respond to maternal medical emergencies -Improving healthcare delivery systems for patients to access home dialysis -Improving autism screening, diagnosis, & services among Black children www.medpagetoday.com/washington-w...
medpagetoday.com
Senators Blast RFK Jr. Over AHRQ Grant Cancellations
'We demand that you immediately rescind these cancellations,' says group of Democrats
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jdelafuente.bsky.social @jdelafuente.bsky.social · 05/06/2026
1/9 🚨 BREAKING OUT OF STEALTH MODE 🚨 Multivariate GWAS in Genomic SEM now runs on a laptop! New preprint + package update: a closed-form analytic solution makes multivariate GWAS ~800× faster, cutting runtimes from hours on HPC clusters to minutes on a personal computer.
static.klipy.com
The Predator Emerges
ALT: The Predator Emerges
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Ted Schwaba @tedmond.bsky.social · 01/05/2026
This reviewer is a perfect illustration of a person with good intentions, who I probably agree with on a ton of things, who starts from the premise that "it is bad if things are partially heritable, so they cannot be" and then works from there. Acknowledging genetics is not endorsing eugenics!
lareviewofbooks.org
Natural Election | Los Angeles Review of Books
Kathryn Paige Harden’s new book offers a defense of a kind of Scientific Calvinism that converges with the eugenicist ideals of the contemporary Far Right.
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moin syed @syeducation.bsky.social · 24/02/2026
New post! "Valuing the Process vs. the Product in Research," in which I try to describe some of the tensions around using GenAI/LLMs in scientific research, and why it can be so difficult to have productive conversations on the topic. getsyeducated.substack.com/p/valuing-th...
getsyeducated.substack.com
Valuing the Process vs. the Product in Research
On reasonable resistance to using GenAI in research
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Elise Cutts @elisecutts.bsky.social · 05/02/2026
Newsletter up. Rant incoming. Pop sci mostly reaches educated, left-leaning, wealthy readers — including, of course, scientists and science writers. I increasingly believe the gap between the real general audience and what's called "general audience" in scicomm is huge and worth talking about: 🧪
reviewertoo.com
Pop science doesn't reach a "general audience"
Pop sci readers are wealthy, educated, and left-leaning
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Rosa Cheesman @rosacheesman.bsky.social · 04/11/2025
1/ 🚨New paper in Nature Genetics Genetic factors are associated with the educational fields people study, from arts to engineering. Article: www.nature.com/articles/s41... FAQ: www.thehastingscenter.org/genomic-find...
nature.com
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
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Laurel Raffington @laraffington.bsky.social · 28/10/2025
We have an open postdoc position in Social Science Genomics in Berlin! Includes gene-environment interplay within German population cohorts & experimental online survey studies to probe public perceptions of potential DNA biomarker applications 🔗 www.mpib-berlin.mpg.de/2196134/2025...
mpib-berlin.mpg.de
Postdoctoral Position in Social Science Genomics | Max Planck Research Group Biosocial
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Elliot Tucker-Drob @tuckerdrob.bsky.social · 01/10/2025
Non-paywalled link to my commentary on @vw1234.bsky.social and colleagues new paper in @nature.com rdcu.be/eI2NG
rdcu.be
Early- and late-diagnosed autism are genetically distinct | Nature
Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development. Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development.
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Elliot Tucker-Drob @tuckerdrob.bsky.social · 19/08/2025
A deep and thought-provoking lecture that is definitely worth watching all the way through.
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Ted Schwaba @tedmond.bsky.social · 20/05/2025
Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
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Ted Schwaba @tedmond.bsky.social · 07/03/2025
Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41... (feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)
nature.com
Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex - Nature Genetics
Genomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric...
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Elliot Tucker-Drob @tuckerdrob.bsky.social · 05/02/2025
Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity and differentiation of traits across the severity spectrum. Tweetorial coming soon.
Genetic correlations between MDD and each neuroticism cut point. The line of best fit is shown, based
on a linear regression model, with parameters estimated using generalized least squares (GLS).Standardized results (with standard errors) for two-factor genomic structural
equation model as estimated using GenomicSEM software. Standardized results (with standard errors) for three-severity factor genomic structural
equation model as estimated using GenomicSEM software.
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Maggie Clapp Sullivan @mclapps.bsky.social · 15/01/2024
🚨 New paper! In this review, we explore factor indeterminacy and outline how we can use genetic data to test the validity of latent factors. tinyurl.com/5n75446y With @tedmond.bsky.social , @tuckerdrob.bsky.social , @kph3k.bsky.social , @andrewgrotzinger.bsky.social , and @michelnivard.bsky.social
nature.com
Beyond the factor indeterminacy problem using genome-wide association data - Nature Human Behaviour
The authors address the central criticism of latent variable models in behavioural science, which is that a wide range of causal models may account for the observed data (the factor indeterminacy prob...
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