iiinova — where your digital self keeps evolving

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Leibniz-HKI @leibniz-hki.de · 11/12/2025

The research network #PerMiCCion, funded by the #BMFTR, enters its 2nd funding phase to uncover why more young adults develop colorectal #cancer, and how the gut microbiome can enable earlier detection and personalized prevention. ➡️ lmy.de/fZkRG @mbdlab.bsky.social @uni-jena.de #Microverse

Transparent anatomical 3D illustration of the human abdomen showing the digestive tract, with the colon highlighted in bright orange and red to indicate inflammation and tumor-affected areas. © Adobe Stock / appledesign

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Balance of the Microverse @microverse.bsky.social · 03/12/2025

🧬 New study in @natmicrobiol.nature.com: Our gut’s “chemical cookbook” is highly individual. Researchers from our Cluster at @uni-jena.de & @leibniz-hki.de show why healthy eating affects everyone differently — and how #microbiome insights could enable truly personalized #nutrition.

microverse-cluster.de

The Power of Gut Enzymes: Why Healthy Eating Affects Everyo…

Researchers from the Cluster of Excellence »Balance of the Microverse« at the University of Jena and the Leibniz…

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Leibniz-HKI @leibniz-hki.de · 25/07/2025

Sporty 🏸, curious, and far from cliché: In our #July feature of our #calendar, colleagues Tongta Sae-Ong & Sascha Schäuble share their paths in bioinformatics, love for sports, and why science is as much about people as it is about data: lmy.de/fTKMI #FacesOfScience #LeibnizHKI @mbdlab.bsky.social

Sascha Schäuble concentrates on his work at his standing desk in the office. In the accompanying quote, he explains his work at the Leibniz-HKI: “As Head of Integrative Data Analysis, I am a bioinformatic hub at the Leibniz-HKI and open for collaboration with all groups on data (pre-)processing, analysis and integration.”

Tongta Sae-Ong is sitting in a dress on a chair similar to a bar stool with a “Peanuts” coffee cup in her hand, the arm with the cup is leaning on a high table in front of her. There is a large window in the background. She is in conversation with her colleague Sascha Schäuble, of whom only his knees and one hand are visible. In the accompanying quote, she explains her work at the Leibniz-HKI: “As a bioinformatician my projects focus on metagenomics. After studying fungal genomes, I now work on the plant microbiome.”

Tongta Sae-Ong and Sascha Schäuble play a game of ping-pong across a large wooden table and benches on a green lawn. Lush green deciduous trees can be seen in the background, obscuring part of a modern Leibniz-HKI building behind them. The accompanying quote from Sascha reads: “You’re only limited by your imagination.”

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Leibniz-HKI @leibniz-hki.de · 15/07/2025

In a new @naturemedicine.bsky.social study, 8 weeks of VR training with REVERIE improved working memory, olfaction & altered the gut microbiome in teens with #overweight – without physical exercise. P.S.: We still like exercise though! 🤫 ➡️ Paper: doi.org/10.1038/s415... @mbdlab.bsky.social

A student tries out VR glasses at the Chair for Research on Teaching and Learning of the University of Jena.

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Panagiotou's lab @mbdlab.bsky.social · 23/06/2025

World Microbiome Day is coming up! Please check our European Initiative MiccrobioTAckle!

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Panagiotou's lab @mbdlab.bsky.social · 15/06/2025

Our European doctoral Network funded by @horizoneu.bsky.social MiCCrobioTAckle is now on Bluesky! Follow the account to learn about our progress on the gut microbiome and cancer cachexia!

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Leibniz-HKI @leibniz-hki.de · 12/06/2025

The #MiCCrobioTAckle network held its first on-site training in Jena! 12 PhD researchers learned R basics for #microbiome data at #LeibnizHKI. The EU project explores the gut microbiome’s role in cancer cachexia. 👉 lmy.de/QLhdA 👥 @mbdlab.bsky.social 🌐 www.miccrobiotackle.eu

Group picture of the young international participants of the first MiCCrobioTAckle project training event on the grounds of the Leibniz-HKI in Jena. In the background are green trees and modern buildings, the sky is bright and blue with some big white clouds.

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Universität Jena @uni-jena.de · 22/05/2025

Gianni Panagiotou and his team @mbdlab.bsky.social in the Cluster of Excellence @microverse.bsky.social examine how the gut #microbiome impacts the development & progression of diseases. Read more in the latest issue of the #UniJena research magazine. ➡️ www.lichtgedanken.uni-jena.de/en/3146/how-...

Gianni Panagiotou, Professor of Microbiome Dynamics, standing next to a whiteboard.

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JSMC @jsmc-info.bsky.social · 24/03/2025

Our lecture series #MiCoCo is back! On 2 April, Prof. Panagiotou @mbdlab.bsky.social will give a talk on "Colorectal Cancer Through the Lens of Gut Microbial Metabolism". 📍 Lecture Hall Erbertstraße 1 Everyone is welcome!

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Panagiotou's lab @mbdlab.bsky.social · 30/01/2025

Spread the word. 1 open position at our MSCA-DN MiCCrobioTAckle (miccrobiotackle.eu). There is 1 position at our partner's location at AUMC to work on an in-silico approach to FMT design. Project info & application here: www.leibniz-hki.de/en/mbd-newsd... Application deadline 𝗠𝗮𝗿𝗰𝗵 𝟯𝟭, 𝟮𝟬𝟮𝟱.

leibniz-hki.de

PhD position available in the Netherlands

As part of the Marie Sklodowska-Curie Action Doctoral Network (MSCA-DN) MiCCrobioTackle (miccrobiotackle.eu), our …

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Panagiotou's lab @mbdlab.bsky.social · 30/01/2025

leibniz-hki.de

PhD position available in the Netherlands

As part of the Marie Sklodowska-Curie Action Doctoral Network (MSCA-DN) MiCCrobioTackle (miccrobiotackle.eu), our …

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

We are incredibly grateful to the DFG (funds via @microverse.bsky.social ) and Horizon Europe (BestTreat) for supporting our project. 12/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

Congratulations to all authors, including our collaborators Weiping Jia, Aimin Xu, Bjorn Nielsen, Max Nieuwdorp, and Rohit Loomba for their great work. 11/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

Our study reveals robust and highly specific NAFLD signatures and offers a more realistic microbiome-therapeutics approach over individual species for this complex disease. 10/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

Finally, using these signatures coupled with further mediation analysis and metabolic dependency modeling, we propose synergistic defined microbial consortia associated with NAFLD phenotype in overweight and lean individuals, respectively. 9/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

We then created ML models (RF) using bacterial species and predicted metabolites to classify NAFLD-obese and controls. These models are highly accurate and specific to NAFLD compared to other metabolic diseases. 8/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

We found that NAFLD-obese and NAFLD-lean individuals have different microbiome taxonic profiles than other co-ocurring metabolic diseases. Predicted metabolites (GSMM) profiles were a priori not different between groups. 7/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

In this study, we mined public data and analyze shotgun metagenomics of 1206 patients with clear information on NAFLD status and other metabolic diseases and well-characterized clinical profiles. 6/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

Another challenge is that studies have not considered differences between obese and lean patients (around 20% of those suffering NAFLD). Could the microbiome-signatures differ between these 2 groups? 5/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

Us and others have shown that the gut microbiome could be a powerful diagnostic tool for NAFLD. But, NAFLD can co-occur with other metabolic diseases like T2D, obesity, etc. How specific are the microbiome-signatures found in NAFLD patients? 4/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

NAFLD (non-alcoholic fatty liver) has become a global epidemic, affecting around 40% of the Western world and in many cases undiagnosed until reaching severe stages 3/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

In a nutshell: In a large-scale study mining public data, we identified microbiome-signatures that can differenriate between NAFLD and other commonly co-ocurring metabolic diseases. This could help in the more precise use of microbiome-based therapies for NAFLD. 2/n

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025

Happy to share our new paper “Discovery of robust and highly specific microbiome signatures of non-alcoholic fatty liver disease”, published in @microbiomej.bsky.social rdcu.be/d6Z2j More information below 1/n

rdcu.be

Discovery of robust and highly specific microbiome signatures of non-alcoholic fatty liver disease | Microbiome

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Panagiotou's lab @mbdlab.bsky.social · 12/12/2024

We are happy to share our review on the beneficial role of the gut microbiome and diet in colorectal cancer, particularly for an early onset of the disease. This is a joint effort with partners in our BMBF-funded consortium PerMiCCion (permiccion.de) Happy reading! www.embopress.org/doi/full/10....

embopress.org

Beneficial microbiome and diet interplay in early-onset colorectal cancer | EMBO Molecular Medicine

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

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Panagiotou's lab @mbdlab.bsky.social · 12/12/2024

embopress.org

Beneficial microbiome and diet interplay in early-onset colorectal cancer | EMBO Molecular Medicine

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

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Panagiotou's lab @mbdlab.bsky.social · 24/11/2024

We are hiring! Several positions are available at our group at LeibnizHKI: - PhD in Microbiome Systems Biology - PhD in Metagenomics - Postdoc in Microbiome research - Team assistant Applications here: lnkd.in/gHnx5_dc If you know anyone interested, please RT!

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Hall Lab @halllab.bsky.social · 06/12/2024

🚨 PhD Opportunity @halllab.bsky.social! 🔬 Decoding Early Life Microbiota & Host Interactions 🧬 Ideal for those with bioinformatics/microbiome experience 🌍 Open to international candidates (MSCA mobility rules apply). 📅 Deadline: 18th Dec 🌐 Apply now: www.findaphd.com/phds/project...

findaphd.com

Decoding Early Life Microbiota and Host Interactions at University of Birmingham on FindAPhD.com

PhD Project - Decoding Early Life Microbiota and Host Interactions at University of Birmingham, listed on FindAPhD.com

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Samuel Aroney @aroneys.bsky.social · 26/11/2024

Excited to share “Bin Chicken”, substantially improving genome recovery through rational metagenomic assembly. Applied to public 🌍 metagenomes, it recovered 24,000 novel species 🦠, including 6 novel phyla. doi.org/10.1101/2024... @wwood @rhysnewell @CMR_QUT 🧵1/6

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Panagiotou's lab @mbdlab.bsky.social · 24/11/2024

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Gabrielle Brewer @gabriellebrewer.bsky.social · 22/11/2024

More #NatureReviewsCancer updates 🚨 We recently launched a collection on the #microbiome in cancer. While its role is still debated, the collection presents a selection of articles from #SpringerNature journals to highlight our current understandings.🧫🦠 😀👉 bit.ly/48u8WFH

nature.com

The microbiome in cancer

The gut microbiome plays a crucial role in cancer development and progression, by influencing the host immune system and metabolism.

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Francesco Beghini @fbeghini.bsky.social · 21/11/2024

Excited to share our last work on microbiome transmission and social interactions published on Nature! The more people you interact with, the more similar your microbiome is. www.nature.com/articles/s41...

nature.com

Gut microbiome strain-sharing within isolated village social networks - Nature

An investigation into the relationship between network structure and gut microbiome composition among people living in 18 isolated Honduras villages reveals that strain-sharing can be mediated by...

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