Panagiotou's lab @mbdlab.bsky.social · 21/01/2025Finally, using these signatures coupled with further mediation analysis and metabolic dependency modeling, we propose synergistic defined microbial consortia associated with NAFLD phenotype in overweight and lean individuals, respectively. 9/n 100
Panagiotou's lab @mbdlab.bsky.social · 21/01/2025We then created ML models (RF) using bacterial species and predicted metabolites to classify NAFLD-obese and controls. These models are highly accurate and specific to NAFLD compared to other metabolic diseases. 8/n 110
Panagiotou's lab @mbdlab.bsky.social · 21/01/2025We found that NAFLD-obese and NAFLD-lean individuals have different microbiome taxonic profiles than other co-ocurring metabolic diseases. Predicted metabolites (GSMM) profiles were a priori not different between groups. 7/n 100
Panagiotou's lab @mbdlab.bsky.social · 21/01/2025In this study, we mined public data and analyze shotgun metagenomics of 1206 patients with clear information on NAFLD status and other metabolic diseases and well-characterized clinical profiles. 6/n 100