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Panagiotou's lab

@mbdlab.bsky.social
163 followers 336 following 18 posts

Microbiome Dynamics Department at LeibnizHKI. We study how the microbiome impacts health, diet & ecosystems.

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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025
Finally, using these signatures coupled with further mediation analysis and metabolic dependency modeling, we propose synergistic defined microbial consortia associated with NAFLD phenotype in overweight and lean individuals, respectively. 9/n
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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025
We then created ML models (RF) using bacterial species and predicted metabolites to classify NAFLD-obese and controls. These models are highly accurate and specific to NAFLD compared to other metabolic diseases. 8/n
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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025
We found that NAFLD-obese and NAFLD-lean individuals have different microbiome taxonic profiles than other co-ocurring metabolic diseases. Predicted metabolites (GSMM) profiles were a priori not different between groups. 7/n
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Panagiotou's lab @mbdlab.bsky.social · 21/01/2025
In this study, we mined public data and analyze shotgun metagenomics of 1206 patients with clear information on NAFLD status and other metabolic diseases and well-characterized clinical profiles. 6/n
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