Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how it influences tumor cell in...

Summary: Design and characterization of a novel FRET-based tension sensor that can detect myosin-associated forces in living cells.

In cerebral cavernous malformations, mutant cells recruit healthy endothelial cells to form mosaic lesions. Here, the authors show that mutant cells can hijack and reprogram neighboring wildtype cells...

While manual segmentation and tracking of cells from microscopy images remain common practices in biological studies, our work demonstrates the inter- and intra-user variability that can arise from t...

Uroz et al. report that the distinct mechanical properties of brain vasculature versus parenchyma drive cancer cell migration through a talin-dependent mechanism, enabling vessel co-option and metasta...

Cell migration through narrow constrictions during cancer metastasis significantly deforms the nucleus, creating mechanical stress on chromatin. Here, the authors reveal that such chromatin deformatio...

Vinculin is a mechanotransducer that reinforces links between cell adhesions and linear arrays of actin filaments upon myosin-mediated contractility. Both adhesions to the substratum and neighboring c...

Viscosity blunts cell response to stiff matrices in agreement with a pull-and-hold model of molecular clutch-based mechanosensing.