Nature Reviews Microbiology, Published online: 13 March 2026; doi:10.1038/s41579-026-01295-xIn this Review, Otero et al. explore how human herpesviruses evade humoral immune responses and consider the resulting implications for developing effective vaccines and treatments for diseases caused by these common viral pathogens.

Antibodies represent promising drugs for the prevention and treatment of viral infections, especially when efficacious vaccines are unavailable. Determining the dominant mechanisms of Ab-mediated prot...

HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.

Infection by neurovirulent pathogens in utero and during the neonatal period can lead to fetal and neonatal mortality as well as neurological morbidity with lifelong consequences. Fortunately, materna...

Glycoprotein B (gB) serves as the viral fusion protein for herpes simplex virus (HSV), mediating fusion between viral and host membranes resulting in infection. As such, gB represents a potentially cr...

Nonstabilized SARS-CoV-2 spike mRNA vaccination elicited distinct antibodies to either Omicron variants of concern or preemergent sarbecoviruses.

Infection by neurovirulent pathogens in utero and during the neonatal period can lead to fetal and neonatal mortality as well as neurological morbidity with lifelong consequences. Fortunately, materna...