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Guillaume Lajoie

@glajoie.bsky.social
2K followers 10 following 30 posts

Professor at Université de Montréal & Mila -- Québec AI Institute mathematics - neuroscience - artificial intelligence

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Reposted by Guillaume Lajoie
COSYNE @cosynemeeting.bsky.social · 11/09/2026
📢Have work to share with the computational and systems neuroscience community? Abstract submissions for #COSYNE2027 are now open. Deadline: 18 October 2026, 11:59 p.m. AoE Submit your abstract: www.cosyne.org/abstracts-su... #Neuroscience
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Guillaume Lajoie @glajoie.bsky.social · 15/09/2026
In brain-computer interfacing, clever and adaptive decoders help brains learn complex tasks faster. These can impact the nature of solutions learned by the brain. Our new paper is one of the first attempts to study this effect. W/ @neuroamyo.bsky.social and team www.nature.com/articles/s41...
nature.com
Assistive algorithms influence neural representations in motor brain-computer interfaces - Nature Communications
Assistive algorithms are widely used in brain-computer interfaces (BCIs), but their effects on neural representations remain unclear. Here, the authors show that adaptive BCIs lead the brain to learn ...
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Guillaume Lajoie @glajoie.bsky.social · 23/07/2026
Our latest preprint exploring hybrid losses that that aim to maximize unlabelled+labelled data mixes for pretraining "neurofoundation" models. We find all kinds of interesting advantages along the way! check it out👇
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Guillaume Lajoie @glajoie.bsky.social · 21/06/2026
RL has taught sequence models to gather context for extrinsic rewards — solving tasks, hitting goals. But what about intrinsic rewards the model builds from its own predictions? Our new paper on curiosity and open-ended in in-context learning explores this question 🧵👇 arxiv.org/abs/2606.19476
arxiv.org
Can In-Context Learning Support Intrinsic Curiosity?
Effective machine learning depends not only on how we model data, but also on what data we choose to collect. While large sequence models have revolutionized data modeling, the problem of automated da...
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Guillaume Lajoie @glajoie.bsky.social · 21/06/2026
Great paper furthering our understanding of learning dynamics in RNNs. This also caps off the PhD journey of the immensely talented @ezekielwilliams.bsky.social !
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Guillaume Lajoie @glajoie.bsky.social · 21/06/2026
This is exciting work that pushes our understanding of online interactions between direct brain activity and and external effectors. Super grateful to have played a small role in this effort.
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Guillaume Lajoie @glajoie.bsky.social · 15/03/2026
Very interesting ideas to help shape the way we investigate the links between cognition and computation.
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Reposted by Guillaume Lajoie
Nicole Rust @nicolecrust.bsky.social · 13/02/2026
In case you missed these, here's a compilation (for a few giggles to end the week). 1. Instagram post by NYUmed comms (oops). bsky.app/profile/andr...
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Reposted by Guillaume Lajoie
IVADO @ivado.bsky.social · 27/01/2026
🧠 Lancement du Semestre thématique #IVADO sur le Raisonnement et l’IA avec Aaron Courville, @glajoie.bsky.social, @alisongopnik.bsky.social qui ont accueilli ce matin les très nombreux(ses) participant(e) du 1er atelier sur Les bases cognitives du raisonnement (dans l’esprit et l’IA).
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Reposted by Guillaume Lajoie
IVADO @ivado.bsky.social · 27/01/2026
🧠 Launch of the #IVADO Thematic Semester on Reasoning and AI with Aaron Courville, @glajoie.bsky.social and @alisongopnik.bsky.social who welcomed a large number of participants this morning to the first workshop on The Cognitive Basis of Reasoning (in Minds and AI).
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Guillaume Lajoie @glajoie.bsky.social · 20/01/2026
Come join us for this first worshop of a three part series on the computational ingredients of reasoning in minds and AI. Reasoning is a complex term, especially in light of an exploding category of methods in LLMs. These workshops will explore reasoning’s multiple facets.
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Guillaume Lajoie @glajoie.bsky.social · 15/01/2026
New eLife paper is out! We explore the link btw 2-phase perception/generation learning methods like wake-sleep, and what may happen in the brain under on psychedelics. Turns out hallucinations are consistent with hijacking phasic learning, essentially running both wake and sleep phases at once.
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Reposted by Guillaume Lajoie
Blake Richards @tyrellturing.bsky.social · 14/01/2026
Our paper on the "Oneirogen hypothesis" is now up in its revised form on eLife! This is the hypothesis that psychedelics induce a dream-like state, which we show via modelling could explain a variety of perceptual and learning effects from such drugs. elifesciences.org/reviewed-pre... 🧠📈 🧪
elifesciences.org
The oneirogen hypothesis: modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms
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Guillaume Lajoie @glajoie.bsky.social · 06/01/2026
When we learn complex tasks, we chunk them into sub-tasks that our brains orchestrate into action sequences. How we do this is not entirely understood. This work explores how to learn and internally control temporally abstracted sub-tasks in RL/AI with sequence models. arxiv.org/abs/2512.20605
arxiv.org
Emergent temporal abstractions in autoregressive models enable hierarchical reinforcement learning
Large-scale autoregressive models pretrained on next-token prediction and finetuned with reinforcement learning (RL) have achieved unprecedented success on many problem domains. During RL, these model...
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Guillaume Lajoie @glajoie.bsky.social · 05/12/2025
@tyrellturing.bsky.social does a wonderful breakdown of our new theoretical results in multi-agent cooperation. I’m especially excited for the formalization of mechanisms akin to theory-of-mind and other processes that guide how agents model each other. At Paradigms of Intelligence team, Google.
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Guillaume Lajoie @glajoie.bsky.social · 05/12/2025
Incredibly proud of lab members and collaborators for having presented this work at #NeurIPS2025. As flexible sequence models are rapidly developed for neural data, this work demonstrates that they can be used online and substantially benefit from hybrid SSM architectures.
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Reposted by Guillaume Lajoie
Nanda H Krishna @nandahkrishna.bsky.social · 20/09/2025
Excited to share that POSSM has been accepted to #NeurIPS2025! See you in San Diego 🏖️
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Reposted by Guillaume Lajoie
Blake Richards @tyrellturing.bsky.social · 18/09/2025
The CTRL-Labs decoding model paper is out! Saw this presented at Cosyne this year, very cool to see it out. I would say this is the clearest demonstration of scaling laws in neural decoding to-date. www.nature.com/articles/s41... 🧠📈 🧪
nature.com
A generic non-invasive neuromotor interface for human-computer interaction - Nature
A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.
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Reposted by Guillaume Lajoie
Henry Farrell @himself.bsky.social · 18/08/2025
www.programmablemutter.com/p/large-lang... Gopnikism, interactionism, structuralism and role play.
programmablemutter.com
Large language models are cultural technologies. What might that mean?
Four different perspectives
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Guillaume Lajoie @glajoie.bsky.social · 19/08/2025
Compositionality is a central desideratum for intelligent systems...but it's a fuzzy concept and difficult to quantify. In this blog post, lab member @ericelmoznino.bsky.social outlines ideas toward formalizing it & surveys recent work. A must-read for interested researchers in AI and Neuro
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Reposted by Guillaume Lajoie
SilicoLabs @silicolabs.bsky.social · 17/07/2025
🎉 We’re featured by @mila-quebec.bsky.social for our work on immersive, real-world cognitive science. With LABO, researchers can run full XR experiments—no code needed, real behaviour captured. Special thanks to @tyrellturing.bsky.social for being with us from the start! tinyurl.com/yc4wpp3t
mila.quebec
Modernizing Cognitive Health Research with SilicoLabs | Mila
Cognitive health research is a field dedicated to understanding how our brains work when we think, remember, and learn as we go through life. When combined with medical research and rehabilitation…
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Guillaume Lajoie @glajoie.bsky.social · 06/06/2025
Excited to share recent progress on foundation-like models for neural data. As many use cases for generalizable models demand flexible online deployment, here we focus on a design enabling low latency real time use. We use hybrid SSM architecture & demonstrate various transfer learning capabilities
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Reposted by Guillaume Lajoie
Avery HW Ryoo @averyryoo.bsky.social · 06/06/2025
New preprint! 🧠🤖 How do we build neural decoders that are: ⚡️ fast enough for real-time use 🎯 accurate across diverse tasks 🌍 generalizable to new sessions, subjects, and even species? We present POSSM, a hybrid SSM architecture that optimizes for all three of these axes! 🧵1/7
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Santa Fe Institute @sfiscience.bsky.social · 13/05/2025
Reserve your free tickets to SFI's upcoming Community Lecture! lensic.org/events/blais... Blaise Agüera y Arcas’ presents 'Computing, Life, and Intelligence' at the Lensic on 🗓️ May 20, 7:30pm MT in-person or online.
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Reposted by Guillaume Lajoie
Shahab Bakhtiari @shahabbakht.bsky.social · 14/05/2025
Check out our new paper! Vision models often struggle with learning both transformation-invariant and -equivariant representations at the same time. @hafezghm.bsky.social shows that self-supervised prediction with proper inductive biases achieves both simultaneously. (1/4) #MLSky #NeuroAI
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Ezekiel Williams @ezekielwilliams.bsky.social · 22/04/2025
come see @glajoie.bsky.social presenting our poster this week @iclr-conf.bsky.social ! It will be poster #56 in poster session #3. This work was a collaboration between a bunch of us from @mila-quebec.bsky.social and Luca Mazzucato @neuroai-uoregon.bsky.social :)
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Reposted by Guillaume Lajoie
Sarthak Mittal @sarthmit.bsky.social · 28/02/2025
🚨 New Preprint! 🚨 We explore Amortized In-Context Bayesian Posterior Estimation with Niels, @glajoie.bsky.social, Priyank Jaini & @marcusabrubaker.bsky.social ! 🔥 Amortized Conditional Modeling = key to success in large-scale models! We use it to estimate posteriors 🔑 📄 arxiv.org/abs/2502.06601
arxiv.org
Amortized In-Context Bayesian Posterior Estimation
Bayesian inference provides a natural way of incorporating prior beliefs and assigning a probability measure to the space of hypotheses. Current solutions rely on iterative routines like Markov Chain ...
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Reposted by Guillaume Lajoie
Sarthak Mittal @sarthmit.bsky.social · 28/02/2025
🚀 New Preprint! 🚀 In-Context Parametric Inference: Point or Distribution Estimators? Thrilled to share our work on inferring probabilistic model parameters explicitly conditioned on data, in collab with @yoshuabengio.bsky.social, Nikolay Malkin & @glajoie.bsky.social! 🔗 arxiv.org/abs/2502.11617
arxiv.org
In-Context Parametric Inference: Point or Distribution Estimators?
Bayesian and frequentist inference are two fundamental paradigms in statistical estimation. Bayesian methods treat hypotheses as random variables, incorporating priors and updating beliefs via Bayes' ...
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Erica Busch @elbusch.bsky.social · 04/04/2025
New preprint! Excited to share our latest work “Accelerated learning of a noninvasive human brain-computer interface via manifold geometry” ft. outstanding former undergraduate Chandra Fincke, @glajoie.bsky.social, @krishnaswamylab.bsky.social, and @wutsaiyale.bsky.social's Nick Turk-Browne 1/8
doi.org
Accelerated learning of a noninvasive human brain-computer interface via manifold geometry
Brain-computer interfaces (BCIs) promise to restore and enhance a wide range of human capabilities. However, a barrier to the adoption of BCIs is how long it can take users to learn to control them. W...
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Reposted by Guillaume Lajoie
Avery HW Ryoo @averyryoo.bsky.social · 04/04/2025
Very late, but had a 🔥 time at my first Cosyne presenting my work with @nandahkrishna.bsky.social, Ximeng Mao, @mattperich.bsky.social, and @glajoie.bsky.social on real-time neural decoding with hybrid SSMs. Keep an eye out for a preprint (hopefully) soon 👀 #Cosyne2025 @cosynemeeting.bsky.social
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Guillaume Lajoie @glajoie.bsky.social · 03/04/2025
Fresh updates on our efforts to understand the effects of online error manipulation during learing. Turns out learning a task with assistive devices (think training wheels) changes how credit assignment mechanisms shapes neural representations in the brain.
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Reposted by Guillaume Lajoie
Ezekiel Williams @ezekielwilliams.bsky.social · 25/03/2025
1/7: Super excited to share our new paper! This one should be of interest to neuroscientists and deep learning theory folks. This paper was a collaboration with Alexandre Payeur, @averyryoo.bsky.social, Thomas Jiralerspong, @mattperich.bsky.social, Luca Mazzucato, @glajoie.bsky.social
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Guillaume Lajoie @glajoie.bsky.social · 25/03/2025
If you'll be at COSYNE workshops, we got a capstone party planned !
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Reposted by Guillaume Lajoie
Blake Richards @tyrellturing.bsky.social · 24/03/2025
Coming to the #Cosyne2025 workshops? Wanna dance on the final night? We got you covered. @glajoie.bsky.social and I have organized a party in Tremblant. Come and get on the dance floor y'all. 🕺 April 1st 10PM-3AM Location: Le P'tit Caribou DJs Mat Moebius, Xanarelle, and Prosocial Please share!
Party poster for dance party on final night of Cosyne 2025 workshops. It will take place April 1st, 2025, 10PM to 3AM at Le P'tit Caribou.
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Guillaume Lajoie @glajoie.bsky.social · 28/02/2025
As sequence models and in-context conditioning for inference are being developed to perform all kinds of ML tasks, we make systematic and tracktable evaluations to compare point v.s. distributional estimates . imo a key step to scale predictive modeling for general ML
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Mila - Institut québécois d'IA @mila-quebec.bsky.social · 20/02/2025
This week, we’re unveiling two members for the AI Insights for Policymakers program: @glajoie.bsky.social (Mila) and Laleh Seyyed-Kalantari (York University). Register here to partner with them and overcome your AI and policy-related challenges: mila.quebec/en/ai4humani...
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Mila - Institut québécois d'IA @mila-quebec.bsky.social · 20/02/2025
Voici deux nouveaux experts du programme Perspectives sur l’IA pour les responsables des politiques : @glajoie.bsky.social (Mila) et Laleh Seyyed-Kalantari (York Univ.) Échangez avec eux et relevez vos défis liés à l'IA et aux politiques. Inscrivez-vous ici mila.quebec/fr/ia-pour-l...
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The Transmitter @thetransmitter.bsky.social · 07/02/2025
The earliest studies on necessary and sufficient neural populations were performed on simple invertebrate circuits. In her latest column, @neurograce.bsky.social asks if this logic still serves us as we tackle more sophisticated outputs. www.thetransmitter.org/systems-neur...
thetransmitter.org
Claims of necessity, sufficiency don’t work well for studies of complex systems
Early studies on necessary and sufficient neural populations were done on simple invertebrate circuits. Does this logic work for complex outputs?
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Yoshua Bengio @yoshuabengio.bsky.social · 04/02/2025
@theguardian.com has produced an excellent recap of some of the key points of the International AI Safety Report. Full article below: www.theguardian.com/technology/2...
theguardian.com
What International AI Safety report says on jobs, climate, cyberwar and more
Wide-ranging investigation says impact on work likely to be profound, but opinion on risk of human extinction varies
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Reposted by Guillaume Lajoie
Brokoslaw Laschowski @drlaschowski.bsky.social · 13/01/2025
Talk by Guillaume Lajoie at the Montreal AI and Neuroscience (MAIN) Conference on credit assignment in neural networks without plasticity. #neuroscience #neuroAI #AI #compneuro @glajoie.bsky.social www.youtube.com/watch?v=CvCq...
youtube.com
Guillaume Lajoie - Credit assignment in neural networks without plasticity
YouTube video by MAIN Conference
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Guillaume Lajoie @glajoie.bsky.social · 09/01/2025
Long time coming. A very cool project that showcases the advantages of single neuron adaptation in RNNs. #PLOSCompBio: Neural networks with optimized single-neuron adaptation uncover biologically plausible regulari ... dx.plos.org/10.1371/jour... Props to V. Geadah and co-authors!
dx.plos.org
Neural networks with optimized single-neuron adaptation uncover biologically plausible regularization
Author summary Evolution has shaped neural circuits in the brain to support complex tasks and behavior. In doing so, single neurons have developed intriguing coding properties such as heterogeneous an...
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Reposted by Guillaume Lajoie
Mila - Institut québécois d'IA @mila-quebec.bsky.social · 11/12/2024
Mila has a booth at @neuripsconf.bsky.social! Come chat with us if you want to join our research institute or to meet with some of our researchers at #104, West Exhibition Hall A.
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Patrick Mineault @patrickmineault.bsky.social · 02/12/2024
Excited to release what we’ve been working on at Amaranth Foundation, our latest whitepaper, NeuroAI for AI safety! A detailed, ambitious roadmap for how neuroscience research can help build safer AI systems while accelerating both virtual neuroscience and neurotech. 1/N
Different paths toward safe AI at different Marr's levels
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Guillaume Lajoie @glajoie.bsky.social · 23/10/2024
Compositional representations are a key attributes of intelligent systems that generalize well. An issue is that there is no robust way to quantify compositionality. Below is our attempt at such a quantifiable measurement. arxiv.org/abs/2410.148... w/ E Elmoznino & T Jiralerspong & Y Bengio
arxiv.org
A Complexity-Based Theory of Compositionality
Compositionality is believed to be fundamental to intelligence. In humans, it underlies the structure of thought, language, and higher-level reasoning. In AI, compositional representations can enable ...
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Guillaume Lajoie @glajoie.bsky.social · 23/10/2024
In-context learnin (ICL) is one of the most exciting part of the LLM boom. Sequence models (not just LLMs) implement on-the-fly models conditionned on inputs w/o weight updates! Q: are ICL models better than «in-weights» ones? A: some times ICL is better than standard opt. tinyurl.com/jbzzfyey
arxiv.org
In-context learning and Occam's razor
The goal of machine learning is generalization. While the No Free Lunch Theorem states that we cannot obtain theoretical guarantees for generalization without further assumptions, in practice we obser...
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Guillaume Lajoie @glajoie.bsky.social · 16/10/2024
How continuous neural activity learns and support discrete, symbolic & compositional processes remains an important question for cog. sci. and AI. In this preprint we explore ways in which both symbolic and sub-symbolic processing could be achieved using attractor dynamics. arxiv.org/abs/2310.01807
arxiv.org
Discrete, compositional, and symbolic representations through attractor dynamics
Symbolic systems are powerful frameworks for modeling cognitive processes as they encapsulate the rules and relationships fundamental to many aspects of human reasoning and behavior. Central to these ...
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Guillaume Lajoie @glajoie.bsky.social · 09/10/2024
New preprint where we ask if the psychedelic-induced hallucinations can be explained by the role of dendrites in learning mechanisms in the brain. In short: classical psychedellics might hijack physiological gating mechanisms in generative learning.
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Guillaume Lajoie @glajoie.bsky.social · 08/10/2024
Investigating the experimentally-verifiable impact of different credit assignment mechanisms for learning in the brain is a crucial endeavor for computational neuroscience. Here is our take for motor learnning and the RL/SL question when looking at neural representations in cortex.
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Blake Richards @tyrellturing.bsky.social · 26/09/2024
As an aside, I also just learned a new word from this paper! It is ultracrepidarianism, which is offering opinions beyond one's knowledge. Man, I know a lot of ultracrepidarian people out there... 😅😘
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Guillaume Lajoie @glajoie.bsky.social · 13/09/2024
The call for #Cosyne25 workshop proposals is now live! cosyne.org/workshops-call Deadline: October 4th, 2024 please repost!
cosyne.org
Call For Proposals — COSYNE
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