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Matt Girgenti

@mattgirgenti.bsky.social
119 followers 110 following 18 posts

Assistant Prof YalePsych and DeptVetAffairs. Single-cell, Genomics, Neuroscience, Psychiatric Genetics. Dad of 2. MtG collector. Opinions are mine

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Matt Girgenti @mattgirgenti.bsky.social · 15/02/2026
Excited to share our newest #SingleCell work on human #AlcoholUseDisorder in #Amygdala out in @natcomms.nature.com Paper: tinyurl.com/3xh54ath Data: zenodo.org/records/1765... Code: github.com/mjgirgenti/A... #Neuroscience #AlcoholUseDisorder #SingleCell #Epigenomics #GeneRegulation
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Ellen Hoffman @ehoffmanlab.bsky.social · 01/02/2026
We're hiring! The Hoffman lab at Yale is recruiting for Post-Doctoral Associate and Post-Graduate Associate positions available immediately. Join us! www.hoffmanlab.net/jobs #zebrafish #zebrafishjobs
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Elizabeth Goldfarb @evgoldfarb.bsky.social · 11/12/2025
How does cortisol tune brain networks to form strong emotional memories? Excited to share new work led by amazing former RA Flory Huang w collabs Rajita Sinha and @toddc.bsky.social #neuroskyence www.science.org/doi/10.1126/...
science.org
Dynamic brain mechanisms supporting salient memories under cortisol
The stress-related hormone cortisol alters dynamic brain networks predicting memory and arousal to promote emotional memories.
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Matt Girgenti @mattgirgenti.bsky.social · 10/12/2025
Looking forward to your visit and talk!
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Matt Girgenti @mattgirgenti.bsky.social · 04/11/2025
🚨 New paper alert from our lab @yaleschoolofmed.bsky.social ! We generated DNA methylation maps from 6 postmortem brain regions (amygdala + hippocampus subregions) in PTSD, MDD, and control donors — the largest dataset of its kind! 🧠✨ 📖 Read more: www.biologicalpsychiatryjournal.com/article/S000...
biologicalpsychiatryjournal.com
Mapping DNA methylation signatures to identify epigenetic variation across subcortical regions of the human PTSD brain
Post-traumatic stress disorder is a mental disorder that may occur in the aftermath of severe psychological trauma. Epigenetic changes in the brain may play a critical role in understanding the neurob...
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Heather Snell @heatherdsnell.bsky.social · 10/09/2025
The Snell lab is seeking a Postbaccalaureate researcher and Postdoctoral associate to join our team. More details here: www.snelllab.org/contact-2
snelllab.org
Contact | Snell Lab
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Jeremy Day @daylab.bsky.social · 15/08/2025
A summary of NIH Director Jay Bhattacharya's comments during his visit to UAB today for a town hall style presentation: -Important for scientific work addressing our nation's health problems to be done in the same communities where those problems are concentrated
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Sergiu P. Pasca @sergiuppasca.bsky.social · 19/07/2025
Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience With the great @rebeccalevymdphd.bsky.social
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allen institute @alleninstitute.org · 18/06/2025
Meet MapMyCells! This tool saves neuroscientists precious time by comparing their data to massive, high-quality reference datasets, including our whole mouse brain multi-omics atlas and the Seattle Alzheimer’s Disease Brain Cell Atlas. 🧠📈 portal.brain-map.org/atlases-and-... #studyBRAIN
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Matt Girgenti @mattgirgenti.bsky.social · 18/06/2025
Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today. Paper: www.nature.com/articles/s41... News and views: www.nature.com/articles/d41... Press: medicine.yale.edu/news-article... Data: doi.org/10.5281/zeno... Code: github.com/mjgirgenti/P...
nature.com
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD - Nature
A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.
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Yale Neuroscience @yaleneuro.bsky.social · 30/05/2025
We recently celebrated our annual Neuroscience Retreat🧠👥 Thank you so much to everyone who came and made it such a memorable retreat full of science, collaboration, and community🤝🤗📸👇
Faculty member Aaron Kuan presenting his talk in front of several rows of department members.Students and postdocs presenting their work at the poster session.Round table of smiling trainees (despite the clouds), with the Long Island Sound in the background.Photo of the graduate students present at the retreat, with the beach in the background.
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Yale Neuroscience @yaleneuro.bsky.social · 12/05/2025
Join us today at noon 🕛 for a seminar by @michael-e-ward.bsky.social, MD, PhD, from NIH/NINDS, on neuronal lysosomes in health and disease. Thank you to @yaleneuro.bsky.social's Shaul Yogev and @sugarrayy.bsky.social for hosting! We hope to see you there!
Flyer for 05/12/2025 seminar by Michael Ward, MD, PhD, showing his headshot, talk title "The Hidden Biology of Neuronal Lysosomes in Health and Disease", and location room 180 at 100 College St.
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Yale Kavli Institute for Neuroscience @kavliatyale.bsky.social · 09/05/2025
In a new @yale.edu study, researchers led by @mattgirgenti.bsky.social from #YalePsychiatry used a comprehensive multi-omic approach to analyze postmortem brain 🧠 genomics and investigate the molecular differences 🧬 in PTSD and major depressive disorder 🔍
medicine.yale.edu
A Multi-Omic Approach Implicates Novel Protein Dysregulation in Post-Traumatic Stress Disorder
Yale scientists, led by senior author Matthew Girgenti, PhD, assistant professor of psychiatry, established a brain multi-omic and multi-region analysis
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Matt Girgenti @mattgirgenti.bsky.social · 30/04/2025
Excited to share our latest study of the PTSD prefrontal cortex out @GenomeMedicine. rdcu.be/ejZ3T Our systems biology approach established a brain multi-omic, multi-region analysis comprising individuals with PTSD and MDD
rdcu.be
A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
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allen institute @alleninstitute.org · 10/04/2025
Hot off the science presses! The largest map of the brain's wiring and activity to date is featured on the cover of @nature.com. 🧠📈 Check out 'Cortex in Context' at: www.nature.com/immersive/d4...
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✺ 𝕸𝖔𝖙𝖍 ✺ @mothsprout.bsky.social · 10/04/2025
Obsessed with this photo I took of a California Condor at the Oregon Zoo looking out into the rain majestically 🌧️
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Alex Kwan @alexkwan.bsky.social · 02/04/2025
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄 Read in @nature.com - www.nature.com/articles/s41... 1/12
nature.com
Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature
A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
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