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Manini AF

@maninialex.bsky.social
107 followers 109 following 2K posts

Professor @MountSinaiNYC, views my own. Director and Founder of Mount Sinai RESPOND Center. icahn.mssm.edu/about/departments/em… See more youtu.be/NJpBa3tDVB4

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Manini AF @maninialex.bsky.social · 15/06/2026
The CDC Fentalog Dashboard has been updated to include >2,500 nonfatal suspected opioid overdose cases with advanced toxicology testing from EDs across the U.S. #medsky 🧵 www.cdc.gov/overdose-pre...
cdc.gov
The Fentalog Study: A Subset of Nonfatal Suspected Opioid-Involved Overdoses with Toxicology Testing
View substances detected in samples from patients experiencing a suspected opioid-involved overdose.
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Manini AF @maninialex.bsky.social · 11/03/2026
New Blue Ridge rankings! 📊 Always humbling to see these rankings; much gratitude for the team behind the numbers. 🔗 brimr.org/brimr-rankin... Proud to see Icahn School of Medicine at Mount Sinai rise to #6 nationally in EM NIH funding (from #7). 🚀 @medsky.social @mountsinainyc.bsky.social
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Manini AF @maninialex.bsky.social · 02/02/2026
The positivity of the novel orphine substance N-propionitrile chlorphine, or "Cychlorphine" in fatal drug overdoses has increased since mid-2025 when the Chinese government placed nitazene analogues under generic control, per CFSRE www.cfsre.org/nps-discover...
cfsre.org
Increase in Fatal Overdoses Linked to Novel Synthetic Opioid N-Propionitrile Chlorphine (Cychlorphine)
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Manini AF @maninialex.bsky.social · 14/01/2026
Our new paper out in Addiction from the multicenter Fentalog Study examines who is more likely to have xylazine detected in non-fatal opioid overdose presenting to the ED. This is patient-level toxicosurveillance. #Xylazine #medsky onlinelibrary.wiley.com/doi/10.1111/... Thread 1/🧵
onlinelibrary.wiley.com
Clinical factors linked to xylazine exposure in emergency department patients with illicit opioid overdose
Background and aims Xylazine, an alpha-2 agonist used in veterinary anesthesia, is increasingly detected in the illicit opioid supply but little is known about the patient level factors associated w...
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Manini AF @maninialex.bsky.social · 12/01/2026
The updated CDC Fentalog Study dashboard is a sobering reminder that the opioid supply is no longer just “fentanyl.” Polysubstance exposure is now the rule, not the exception, and surveillance must evolve accordingly. #PublicHealth 🧵 www.cdc.gov/overdose-pre...
cdc.gov
The Fentalog Study: A Subset of Nonfatal Suspected Opioid-Involved Overdoses with Toxicology Testing
View substances detected in samples from patients experiencing a suspected opioid-involved overdose.
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Manini AF @maninialex.bsky.social · 14/08/2025
1/ 🚨 New TOXIC Fentalog quarterly report on multi-city toxicology testing shows fentanyl & other synthetic drugs dominate suspected overdose cases in US ERs. Findings offer a near real-time look at the street drug market. #medsky #PublicHealth 🧵 www.cfsre.org/nps-discover...
cfsre.org
ToxIC Fentalog Study Group - Quarterly NPS Report: Q2 2025
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Toxicology Investigators Consortium (ToxIC) @toxicacmt.bsky.social · 28/07/2025
Publication: Black patients less likely than white patients to receive outpatient treatment referrals after #opioid #overdose ED visits, per ToxIC Fentalog study. Findings underscore need to address disparities in post-overdose care. ➡️ bit.ly/4l1hFE2 @jamanetworkopen.com @maninialex.bsky.social
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Toxicology Investigators Consortium (ToxIC) @toxicacmt.bsky.social · 22/07/2025
🚨Publication Alert🚨 bit.ly/46U3nl6 #Xylazine found in 1 in 5 nonfatal #opioid #overdoses across 10 U.S. EDs, mostly alongside #fentanyl. Exposure highest in NE vs. rare in the West. Regional trends underscore need for targeted public health responses. #MedToxTuesday @maninialex.bsky.social
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Toxicology Investigators Consortium (ToxIC) @toxicacmt.bsky.social · 07/07/2025
🚨Publication Alert🚨These findings focused on the presence of para-fluorofentanyl (PFF) point to important differences in OD response/treatment linked to fentanyl analogs w/ sex-specific effects that merit further investigation. 📖https://bit.ly/3Gv0gp3 @ziadkazzi.bsky.social @maninialex.bsky.social
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JAMA Network Open @jamanetworkopen.com · 02/07/2025
Among patients with opioid overdose in emergency departments, Black patients received outpatient referrals less frequently than White patients, with rates of 5.7% versus 9.6%. ja.ma/44kiKjO
Disparities in Treatment and Referral After an Opioid Overdose Among Emergency Department Patients
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Manini AF @maninialex.bsky.social · 01/07/2025
July 1. Day One. - You will feel overwhelmed (That’s normal) - Courage isn't the absence of fear - Ask for help early and often - Nobody expects you to know everything - Efficiency comes with time - Trust the process 💙 Welcome. We’ve got your back. #InternYear #Medsky
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Stand Up for Science! @standupforscience.net · 16/06/2025
🚨HUGE SCIENCE WIN ALERT🚨 NIH Grants to be restored en masse!!! Thank you Judge Young for standing up for science! #StandUpforScience #SummerFightforScience
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Expose News @handle.invalid · 14/06/2025
Tianeptine, or ‘gas station heroin,’ can be addictive and cause serious side effects WASHINGTON (AP) — Health officials want you to think twice before buying one of those brightly colored little bottles often sold at gas stations, convenience stores and smoke shops. Sometimes called “gas station…
exposenews.xyz
Tianeptine, or ‘gas station heroin,’ can be addictive and cause serious side effects
WASHINGTON (AP) — Health officials want you to think twice before buying one of those brightly colored little bottles often sold at gas stations, convenience stores and smoke shops. Sometimes called “gas station heroin,” the products are usually marketed as energy shots or cognitive supplements but actually contain tianeptine, an unapproved drug that can be addictive and carries risks of serious side effects.
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Manini AF @maninialex.bsky.social · 11/06/2025
1/ Exciting news: Our team has been awarded a NIDA R01 grant to fund "Fentalog II", a continuation of our groundbreaking collaboration to detect novel fentanyl analogue overdoses in EDs across ten major hospitals over five years. #syntheticopioids #Medsky 🧵 www.mountsinai.org/about/newsro...
mountsinai.org
Mount Sinai Receives $3.8 Million Grant to Study New Synthetic Drugs and Opioid Overdoses in Emergency Departments to Prevent Deaths
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Manini AF @maninialex.bsky.social · 11/06/2025
1/ Our new study in Academic Emergency Medicine analyzed 1,265 ED patients with severe QTc prolongation (≥500 ms) after drug overdose. What predicts dangerous ventricular dysrhythmias in this high-risk group? #cardiotoxins #overdose #Medsky 🧵 pubmed.ncbi.nlm.nih.gov/40492421/
pubmed.ncbi.nlm.nih.gov
Clinical Factors Associated With Ventricular Dysrhythmia in Emergency Department Patients With Severe QTc Prolongation After Drug Overdose - PubMed
In this large international data registry, we identified predictors of ventricular dysrhythmia in patients presenting to the ED after overdose in the setting of severe QTc prolongation.
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Stand Up for Science! @standupforscience.net · 09/06/2025
“In an unusual act of public protest, more than 340 scientists and staff at the National Institutes of Health today released a statement charging NIH officials and their superiors with politicizing science.” www.science.org/content/arti... #StandUpForScience #BethesdaDeclaration
science.org
NIH staff and biomedical community sound alarm about agency politicization, funding slowdown
In test of NIH director’s support of dissent, NIH staff sign Bethesda Declaration urging reversal of grant cuts and freezes
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Manini AF @maninialex.bsky.social · 14/05/2025
Even he agrees with me! #medsky abcnews.go.com/amp/Health/r...
abcnews.go.com
RFK Jr. says people should not take medical advice from him, defends HHS cuts during House hearing
HHS Secretary Robert F. Kennedy Jr. is set to testify before two congressional committees on Wednesday.
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Manini AF @maninialex.bsky.social · 21/04/2025
Great primer and review of the landscape on Methadone for EM docs and emergency care providers #opioidcrisis #Medsky www.acepnow.com/article/libe...
acepnow.com
Liberate Methadone: An Introduction for the Emergency Medicine Physician - ACEP Now
ACEP Now offers real-time clinical news, news from the American College of Emergency Physicians, and news on practice trends and health care reform for the emergency medicine physician. ACEP Now is an...
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Manini AF @maninialex.bsky.social · 11/04/2025
1/ Something weird is happening at NIH. For two weeks in a row, the NIH Weekly Guide has listed zero new funding opportunities. That’s not normal. At all. A short thread on why this is a statistical and strategic outlier: #Medsky
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Art Walaszek, MD @walaszek.art · 10/04/2025
The Trump administration continues to interfere with medical research, this time by forbidding NIH scientists from attending conferences - even on their own time and paying their own way. #medsky www.reuters.com/business/hea...
reuters.com
Exclusive: US NIH scientists barred from attending conferences on their own time and dime
Researchers at the U.S. National Institutes of Health have been told they cannot attend scientific conferences and meetings without official permission, even if they pay their own way and go during time off, three current and former NIH scientists told Reuters.
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Manini AF @maninialex.bsky.social · 03/04/2025
1/ Supervised Consumption Sites (SCSs) work — and Canada has the data to prove it. A recent ecological and spatial analysis shows a striking 67% reduction in overdose mortality within 500m of SCSs. #ACMT2025 #PublicHealth #Medsky
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Kevin Romanchik, MSN, RN @kevinro.medsky.social · 02/04/2025
Caught up on #ThePitt. As an ER charge nurse, I know that mass casualty events are a constant, avoidable reality. Hopefully the show illustrates to even one person the physical and emotional damage from gun violence and moves them to vote for a safer reality for all of us. @everytown.bsky.social
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Eric Topol @erictopol.bsky.social · 02/04/2025
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New @nature.com www.nature.com/articles/d41... nature.com/articles/s41...
nature.com
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
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Jeremy Berg @jeremymberg.bsky.social · 02/04/2025
Collecting my thoughts at the end of one of the worst days of my life... At NIH, > 1300 people were RIFed. These range all across the board from institute directors to low level administrative staff. Communication staff and procurement appear to be hardest hit as anticipated from the HHS plan 1/n
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BK. Titanji @boghuma.bsky.social · 01/04/2025
There is no other way to say this: Today is the day the CDC was essentially dissolved. What's left is a husk. People will die as a direct result. www.wired.com/story/cdc-gu...
wired.com
The CDC Has Been Gutted
Thousands of CDC employees who worked on things like preventing HIV and lead poisoning have been told they were subject to a reduction in force. Experts say people will die.
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Savage-Dunn lab @cswormlab.bsky.social · 01/04/2025
It’s April 1 and still no news about the noncompetitive renewal of our #NIH #R35 award that should enter year 2 today. It’s Schrödinger’s grant How many others are in the same boat? 🧪
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Eric Topol @erictopol.bsky.social · 01/04/2025
How I will remember April Fools' Day 2025. Reckless. My heart is out for these dedicated folks at NIH, FDA and CDC www.statnews.com/2025/04/01/h...
statnews.com
HHS starts layoffs of thousands of workers across its agencies
Layoff notices began arriving early Tuesday for thousands of employees of HHS and its subsidiary agencies, with as many 10,000 workers potentially expected to be hit by the cuts.
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Manini AF @maninialex.bsky.social · 01/04/2025
🧵1/5 New NIH Director Jay Bhattacharya outlines bold new priorities in his welcome message to NIH staff. A physician-economist from Stanford, Bhattacharya signals a shift toward outcomes-driven research and public trust-building. Here’s what’s coming... ⬇️ #MedSky www.nature.com/articles/d41...
nature.com
‘One of the darkest days’: NIH purges agency leadership amid mass layoffs
In shock move, four institute directors at the US biomedical agency are removed from their posts.
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Brittany Charlton @britshmit.bsky.social · 01/04/2025
🧬 Key scientific leaders are being removed! 🧬 NIH directors—known for their expertise and institutional knowledge—are being ousted Result? ✅Undermines public health ✅Erodes scientific integrity ✅Risks unchecked actions A short 🧵 1/ #NIH #CDC #FDA #AcademicSky #MedSky #Science
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Eric Topol @erictopol.bsky.social · 27/03/2025
This doesn't look good, folks www.nature.com/articles/d41...
nature.com
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
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Eric Topol @erictopol.bsky.social · 25/03/2025
In <24 hours, Covid funding is DOGEd across HHS, CDC, NIH as if it and Long Covid didn't exist and there is no worry for future pandemics www.science.org/content/arti... www.nbcnews.com/health/healt... www.science.org/content/arti...
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Manini AF @maninialex.bsky.social · 24/03/2025
🚨 Big news from #IcahnEM 🚨 The Department of Emergency Medicine at the Icahn School of Medicine at Mount Sinai is now ranked #7 nationally in NIH funding, according to the 2024 @brimr_org report. 🧵 #Medsky brimr.org/brimr-rankin... 1/
brimr.org
BRIMR Rankings of NIH Funding in 2024 | BRIMR
The Blue Ridge Institute for Medical Research publishes rankings of institutions, departments, and investigators based on the funding they receive from the NIH.
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Ryan Marino, MD @ryanmarino.bsky.social · 17/03/2025
This is maliciously stupid legislation that will not help anyone & will divert desperately needed resources into already-bloated law enforcement budgets without saving a single life or helping a single American citizen. It even criminalizes (bans completely) compounds that REVERSE FENTANYL OVERDOSE.
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Matt Sztajnkrycer @noobiematt.bsky.social · 10/03/2025
I know a lot of folks are raving about “The Pitt”, which I still need to see. But in 1976, Season 6 of Emergency!, there was a pivotal change in the portrayal of EM that just doesn’t get the recognition it should. The birth of a specialty in the media Ping @ACEPNation
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Toxicology Investigators Consortium (ToxIC) @toxicacmt.bsky.social · 10/03/2025
CHECK IT OUT 🔎Fentalog's newest findings show that less than 1% of patients who experienced an opioid-related overdose required delayed intubation, with most cases relating to non-respiratory related conditions. Read more here: doi.org/10.1016/j.an...
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Manini AF @maninialex.bsky.social · 08/03/2025
🧵1/ Our new study in Annals of Emergency Medicine on opioid OD in the ED: Out of 1,591 cases, delayed intubation (>4h) was rare—only 9 patients (0.6%). What does this mean for emergency medicine? @acmtmedtox.bsky.social #OpioidCrisis #medsky www.annemergmed.com/article/S019...
annemergmed.com
Risk of Delayed Intubation After Presumed Opioid Overdose in the Emergency Department
The objective of this study was to evaluate the optimal duration of monitoring for patients with presumed opioid overdoses prior to a non-ICU admission, particularly in the context of the increasing p...
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Manini AF @maninialex.bsky.social · 07/03/2025
The ER PA I'm working with doesn't know who Noah Wyle is... #medsky
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Jeannette💙 BLUE DOT IN RED BREVARD💙 🐶🌈🗽🐢🤬👩‍🏫📚🇨🇦🇺🇦🇵🇱 @jeannette116.bsky.social · 05/03/2025
Vitamin A and cod liver oil won’t cure measles?! Seriously, one child has died—there is no reason for this to be happening. No child should have measles—let alone die of them in 2025. When will they learn?!
media.tenor.com
a woman in a red jacket is walking down a hallway and says " this is ignorant "
ALT: a woman in a red jacket is walking down a hallway and says " this is ignorant "
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Cannon @cannon4nh.bsky.social · 05/03/2025
From: apnews.com/article/meas...
apnews.com
West Texans, Mennonites at center of measles outbreak choose medical freedom over vaccine mandates
Measles has sickened nearly 160 mostly unvaccinated people in rural West Texas, and a school-age child has died.
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Manini AF @maninialex.bsky.social · 05/03/2025
Do not take medical advice from RFK Jr. He is not a doctor. #notadoctor #medsky
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Dr. Lucky Tran @luckytran.com · 24/02/2025
Studies show that funding from the National Institutes of Health (NIH) contributed to 354 of 356 drugs (99.4%) approved by the FDA from 2010 to 2019. Recklessly slashing NIH funding will mean that patients will be waiting much longer for life-saving treatments.
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ProPublica @propublica.org · 20/02/2025
NEW: Pregnancy became far more dangerous in Texas after the state banned abortion, according to ProPublica’s first-of-its-kind analysis, which found the sepsis rate for women hospitalized as they miscarried in the 2nd trimester shot up by more than 50%. propub.li/43487Tj
propub.li
Texas Banned Abortion. Then Sepsis Rates Soared.
ProPublica’s first-of-its-kind analysis is the most detailed look yet into a rise in life-threatening complications for women experiencing pregnancy loss under Texas’ abortion ban.
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Manini AF @maninialex.bsky.social · 13/02/2025
BREAKING: New memo reveals NIH is issuing new and continuing grants with “the previously approved negotiated indirect cost rates” and not the 15% indirect cost cap the Trump administration was seeking to impose. #Resistance #medsky popular.info/p/breaking-n...
popular.info
BREAKING: NIH admits funding freeze is illegal, will resume issuing grants
An internal memo issued February 12 was obtained by Popular Information.
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Manini AF @maninialex.bsky.social · 08/02/2025
🚨 NIH Indirect Cost Cuts: A Thread 🚨 1/ Late on a Friday, NIH dropped a bombshell—effective next week, ALL NIH grants will have a flat 15% indirect cost cap. No negotiation. No exceptions. 📉💰 grants.nih.gov/grants/guide... #ResearchFunding #SciencePolicy #medsky
grants.nih.gov
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
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Manini AF @maninialex.bsky.social · 07/02/2025
🧵 1/ Our new review paper on #nitazene overdoses: Ultra-potent synthetic opioids bind to the mu-opioid receptor at up to 1.4x the strength of fentanyl. The opioid crisis is evolving, and our response needs to keep up #opioidcrisis #medsky 10.1007/s13181-025-01059-8 pubmed.ncbi.nlm.nih.gov/39904921/
pubmed.ncbi.nlm.nih.gov
Naloxone Dosing and Hospitalization for Nitazene Overdose: A Scoping Review - PubMed
This scoping review reveals a paucity of data on nitazene compound overdoses and identifies a gap in our current opioid crisis response. Most nitazene cases reviewed involved hospitalization, had high...
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Ryan Marino, MD @ryanmarino.bsky.social · 05/02/2025
The people who are trying to set rules for career scientists couldn’t even pass introductory biology or chemistry
Professor Booty PhD
@ProfBootyPhD
About to click "submit" on my new grant proposal, "Diverse signaling mechanisms engaged by systemic all-trans retinoic acid."
Wish me luck!
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Manini AF @maninialex.bsky.social · 31/01/2025
1/ 🚨 Our new study: Patients presenting to US emergency departments (EDs) with opioid overdoses have an HIV prevalence 9x higher than the general population. The opioid crisis and HIV epidemic are colliding in ways we can’t ignore. #OpioidCrisis #HIVResearch #medsky 🧵 doi.org/10.1016/j.dr...
doi.org
Redirecting
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Dr. Sven-Eric Jordt #TobRegSky @sejordt.bsky.social · 31/01/2025
#PainResearch #MedSky #PedSky #addictionsci #neuroskyence 🛟 Godspeed !! FDA approves first new type of pain medication in 25 years www.cnn.com/2025/01/30/h...
cnn.com
FDA approves first new type of pain medication in 25 years | CNN
A new pain relief drug, suzetrigine, is a prescription pill that’s taken every 12 hours after a larger starter dose. It will be sold under the brand name Journavx.
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Manini AF @maninialex.bsky.social · 24/01/2025
1/ 🚨 Our new article in Substance Use & Misuse explores suicidal intent in patients with nonfatal opioid overdoses. Key finding? 6.4% of cases showed intent tied to prescription opioids, not illicit ones. #OpioidCrisis #PublicHealth #medsky 🧵 doi.org/10.1080/1082...
doi.org
Factors Associated with Attempted Suicide Among Emergency Department Patients with Nonfatal Opioid Overdose
To investigate factors associated with suicide attempts among patients presenting after an opioid overdose.This analysis consists of patients enrolled in the Toxicology Investigators Consortium Fen...
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Matty Triplette, MD MPH @matriplette.bsky.social · 23/01/2025
Trump has basically paused the work on the NIH for the time being. This is unprecedented and terrifying. The NIH drives the world’s health research and any pause delays cures. #MedSky www.science.org/content/arti...
science.org
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
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