iiinova — where your digital self keeps evolving

Reposted by Madhur Bain Singh

POP-GEM Lab @popgemlab.bsky.social · 23/12/2025

New open-access Translational Psychiatry paper: multi-omic integration + drug repurposing to identify FDA-approved treatments for opioid use disorder. Led by POP-GEM’s B. Todd Webb, PhD. Approach generalizable across complex traits & disorders. www.nature.com/articles/s41... #OUD

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Andrew Grotzinger @andrewgrotzinger.bsky.social · 10/12/2025

1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...

nature.com

Mapping the genetic landscape across 14 psychiatric disorders - Nature

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...

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loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

nature.com

Estimation and mapping of the missing heritability of human phenotypes - Nature

WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...

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POP-GEM Lab @popgemlab.bsky.social · 26/08/2025

🚨 New paper out! In a collaboration across MVP, FinnGen & UK Biobank, we conducted a phenome-wide study of sex chromosome trisomies (SCT) in 1.5M participants. Findings reveal shared disease risks across SCT. 🔗 www.sciencedirect.com/science/arti...

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Simon Fisher @profsimonfisher.bsky.social · 25/03/2025

“What an odd thing“ wrote Oliver Sacks “to see an entire species playing with listening to meaningless tonal patterns, preoccupied for much of their time by what they call ‘music’...“. Our new paper, led by ace student @giacomobignardi.bsky.social, unpacks this puzzle from a genetic perspective. 🧪

nature.com

Twin modelling reveals partly distinct genetic pathways to music enjoyment - Nature Communications

Here, Bignardi et al. report on a study of over 9,000 Swedish twins that indicates the ability to enjoy music is influenced by multiple partly distinct genetic factors.

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POP-GEM Lab @popgemlab.bsky.social · 28/02/2025

New preprint🌍 Our trans-ancestry GWAS in UK Biobank uncovers novel risk loci for major depression, improving genetic insights across populations. 🔗: www.medrxiv.org/content/10.1... @madhurbsingh.bsky.social @gentyae.bsky.social @pbb319.bsky.social timbigdeli.bsky.social @roseannpeterson.bsky.social

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Arun Durvasula @arundurvasula.bsky.social · 17/02/2025

Excited to share a couple of new items (links below): 1. Our work on gene-environment interactions in the UKBiobank is up at the American Journal of Human Genetics 2. Our work on modeling ancient human population size history is up at Molecular Biology and Evolution

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Michel Nivard @michelnivard.bsky.social · 14/02/2025

🚨NEW PAPER! Together with Wuno Akingbuwa (@wonuola.bsky.social) we developed a way to estimate non-linear genetic correlations. It didnt sit well with us that known non-linear relations (e.g. BMI and MDD with a famous U shaped ) are poorly captured in statistical genetics. 🧵

biorxiv.org

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Marijn Schipper @mjschipper.bsky.social · 11/02/2025

Incredibly proud to see our latest work out in Nature Genetics: www.nature.com/articles/s41... Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥 Special thanks to @daniposthu.bsky.social A full thread describing findings below!

rdcu.be

Prioritizing effector genes at trait-associated loci using multimodal evidence

Nature Genetics - FLAMES is a machine learning approach combining variant fine-mapping, SNP-to-gene annotations and convergence-based gene prioritization scores to identify candidate effector genes...

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POP-GEM Lab @popgemlab.bsky.social · 06/02/2025

New paper! Led by Kirsten J. M. van Hooijdonk & Jacqueline Vink, this study finds no bidirectional causal link between diet/physical activity & depression/anxiety using triangulation. No strong causal evidence! @zoereed.bsky.social @madhurbsingh.bsky.social 📖 doi.org/10.1017/S003...

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Jack Kosmicki @jakphd.bsky.social · 05/02/2025

Nice paper showing ~1/540 people have a sex chromosome trisomy from 3 large biobanks (UKB, FinnGen, MVP) comprising 1.5 million individuals along with their phenotypic impact. www.medrxiv.org/content/10.1...

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Elliot Tucker-Drob @tuckerdrob.bsky.social · 05/02/2025

Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity and differentiation of traits across the severity spectrum. Tweetorial coming soon.

Genetic correlations between MDD and each neuroticism cut point. The line of best fit is shown, based
on a linear regression model, with parameters estimated using generalized least squares (GLS).

Standardized results (with standard errors) for two-factor genomic structural
equation model as estimated using GenomicSEM software.

Standardized results (with standard errors) for three-severity factor genomic structural
equation model as estimated using GenomicSEM software.

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Jonathan Pritchard @jkpritch.bsky.social · 26/01/2025

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

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POP-GEM Lab @popgemlab.bsky.social · 16/01/2025

🚀 New paper by @madhurbsingh.bsky.social on smoking & DNA methylation via twin-based MR using @ntrbiopsy.bsky.social data! Supervised by Mike Neale, @jennyvandongen.bsky.social, & Conor Dolan. Co-authors: @dlapato.bsky.social, @charlesbreeze.bsky.social. 🔗 doi.org/10.1007/s106...

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POP-GEM Lab @popgemlab.bsky.social · 16/01/2025

Thrilled to share some amazing news— @madhurbsingh.bsky.social, supervised by Roseann Peterson, PhD, and Michael C. Neale, PhD, has been awarded VCU VIPBG's Kenneth S. Kendler Award for Excellence in Predoctoral Research!

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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 14/01/2025

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social. www.cell.com/cell/fulltex... A thread 🧵:

Article screenshot of a genome-wide association study of major depression published in the journal Cell

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Michel Nivard @michelnivard.bsky.social · 28/11/2024

🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.

github.com

GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.

A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics

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Stephen Turner @stephenturner.us · 21/11/2024

Tidyplots empowers life scientists with easy code-based data visualization www.biorxiv.org/content/10.1101/202… #rstats

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Michel Nivard @michelnivard.bsky.social · 07/11/2024

New here? or logged back in recently? Find your old friends in statistical and psychiatric genetics in this starter pack, ill try to update frequently, let me know if you want to be added: go.bsky.app/9643dwo

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Michel Nivard @michelnivard.bsky.social · 13/11/2024

@ent3c.bsky.social suggested we need a behaviour genetics starter pack, let me know who to add!

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Nicky Whiffin @nickywhiffin.bsky.social · 15/11/2024

I couldn't spot a starter pack for rare disease / clinical genomics, so I started one: go.bsky.app/SUWZ9Hw Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged. #ClinicalInformatics #genomics #bioinformatics 🖥️🧬

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Madhur Bain Singh @madhurbsingh.bsky.social · 15/11/2024

Excited about this work from my PhD being presented by my advisor, Roseann Peterson, at #WCP2024 in MEX🇲🇽 “Empowering Genomic Discovery for Major Depression: A GWAS Workflow Across Ancestries”! 🌎🧬🧠 11/17, 12-1 PM, Station 1. Advancing trans-ancestry GWAS for genetic insights!💡 #Genetics #Psychiatry

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Nadia Corral Frias @nscorralfrias.bsky.social · 15/11/2024

Don’t miss our poster at #WCP2024! 📊 Dive into “Exploring Depression Phenotypes Across Latin American Genomes” with the LAGC-MDD Working Group 🌎 on 11/16, 12-1 PM at Station 03. Join us to explore GWAS insights on MDD in Latin America! #Genomics #Psychiatry

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Louise Arseneault @larseneault.bsky.social · 31/10/2024

🧬The Genetic Links to Anxiety and Depression @GLADStudy is on the #CatalogueMHM! 🧠 The study looks at the #riskfactors for #depression and #anxiety. Check it out here-> buff.ly/3Al8exO @thaliaeley.bsky.social @psychgenomics.bsky.social @kcl.ac.uk @nihr.bsky.social

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Michel Nivard @michelnivard.bsky.social · 07/05/2024

I have been (foolishly?) searching for peak 2015-2017 twitter "science on socials" magic... In an experiment to recapture that excitement, I talked to @eikofried.bsky.social , in what might veer into podcast territory(?), about a new GWAS of Depression (N > 5 million) www.youtube.com/watch?v=vHvB...

youtube.com

is this an accidental Podcast? Eiko Fried & Michel Nivard discuss a new GWAS of depression preprint

I had a chat with Eiko Fried about a new GWAS of Depression in 685.000 cases and 4.3 million controls... That's like all of Denmark? Here is the GWAS: https:...

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Michel Nivard @michelnivard.bsky.social · 02/05/2024

Our attempt at studying the psychiatric epidemiology of the (potentially causal) relation between educational attainment and psychiatric diagnosis, while triangulating across different methods, led by the amazing @perlinedemange.bsky.social when she was a PhD student with me in Amsterdam..

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Jonathan Pritchard @jkpritch.bsky.social · 19/04/2024

Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritch...

web.stanford.edu

An Owner's Guide to the Human Genome

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Abdel Abdellaoui @dr-appie.bsky.social · 01/03/2024

The International Statistical Genetics Workshop, annually held in Boulder, has its video lectures and practicals organized on a user-friendly website, which will be further expanded as the field evolves 🧬📏 www.colorado.edu/ibg/isgw-onl...

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Abdel Abdellaoui @dr-appie.bsky.social · 10/03/2024

Great job students and faculty of the International Statistical Genetics Workshop 2024 in Boulder, what an amazing week it was, as always 🧬❤️🍻 Next year it's GWAS and sequence data analysis again, see you then: colorado.edu/ibg/workshop

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