New paper from the Crispino lab! www.jci.org/articles/vie.... We examined how suppression of FBXO11, an E3 Ub ligase substrate receptor, could contribute to MDS progression. We found shutdown of an FBXO11-NPM1 protein network in MDS HSPCs, providing new insight for therapeutic approaches.
jci.org
JCI -
FBXO11 suppression rewires an NPM1-centered interactome influencing the progression of myelodysplastic syndrome