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Jeremy Luban 🧬🦠🔬🩺🎸🎻

@lubanlab.bsky.social
531 followers 1.5K following 20 posts

Scientist/Professor/Physician/Musician Serendipity & absurdity

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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Tianxiong (Bear) Yu @tianxiong-bear-yu.bsky.social · 09/03/2025
I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less! authors.elsevier.com/c/1kjdaL7PXu... How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it. #Retrovirus #koala #piRNA More below 👇
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BK. Titanji @boghuma.bsky.social · 29/01/2025
Keep speaking up because it matters. Call out inhumane policies that will kill people. PEPFAR funded HIV drug distribution resumes...for now. www.nytimes.com/2025/01/28/h...
nytimes.com
State Department Permits Distribution of H.I.V. Medications to Resume — for Now (Gift Article)
Experts fear a resurgence of infections in low-income countries if the ban were to continue. The waiver remains in place, while officials review foreign aid programs.
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Daniel Hurdiss @danielhurdiss.bsky.social · 18/01/2025
"MFSD6 is an entry receptor for respiratory enterovirus D68" www.sciencedirect.com/science/arti...
sciencedirect.com
MFSD6 is an entry receptor for respiratory enterovirus D68
Enterovirus D68 (EV-D68) is a leading non-polio enterovirus that causes severe respiratory diseases and poliomyelitis-like illness in children. Viral …
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Eddie Holmes @eddieholmes.bsky.social · 11/01/2025
Lots of new viruses (and other known pathogens) here, especially in carnivores and rodents. Of most interest, a bi-segmented coronavirus sampled from diseased red (lesser) pandas (Ailurus fulgens) and that represents a new genus. Work led my Mang Shi and Shuo Su. www.biorxiv.org/content/10.1...
biorxiv.org
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Flo Débarre @flodebarre.eurosky.social · 11/01/2025
Five years ago (Saturday 11 Jan 2020), first public announcement and availability of a sequence of the new coronavirus. It was posted by @eddieholmes.bsky.social at 01:05 UTC on Virological, and announced on Twitter at 01:08 UTC. ▫️1/ web.archive.org/web/20200118... archive.is/z880d
screenshot of Eddie Holmes' tweet:
@edwardcholmes
All, an initial genome sequence of the coronavirus associated with the Wuhan outbreak is now available at Virological.org here: [link to virological]
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 06/01/2025
Recently: - a severe case of H5N1 infection in British Columbia (required ICU, now recovered) - a lethal case in Louisiana. Features of the Flu sequences from both patients: - closest to flu found in birds - HA mutations likely to be adaptations to humans www.cdc.gov/bird-flu/spo...
cdc.gov
Genetic Sequences of Highly Pathogenic Avian Influenza A(H5N1) Viruses Identified in a Person in Louisiana
CDC has sequenced the influenza viruses in specimens collected from the patient in Louisiana who was
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Flo Débarre @flodebarre.eurosky.social · 05/01/2025
Five years ago (Sunday 5 Jan 2020), scientists in Zhang YongZhen's group in Shanghai obtained their first sequence of the new virus, from samples obtained outside of the official national protocol. They submitted it to GenBank with an embargo. ▫️1/ www.ncbi.nlm.nih.gov/nuccore/MN90...
screenshot of linked website, with submission date highlighted (05-JAN-2020)

LOCUS       MN908947               30473 bp ss-RNA     linear   VRL 12-JAN-2020
DEFINITION  Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete
            genome.
ACCESSION   MN908947
VERSION     MN908947.1
KEYWORDS    .
SOURCE      Wuhan seafood market pneumonia virus
  ORGANISM  Wuhan seafood market pneumonia virus
            Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae;
            Orthocoronavirinae; Betacoronavirus; unclassified Betacoronavirus.
REFERENCE   1  (bases 1 to 30473)
  AUTHORS   Zhang,Y.-Z., Wu,F., Chen,Y.-M., Pei,Y.-Y., Xu,L., Wang,W., Zhao,S.,
            Yu,B., Hu,Y., Tao,Z.-W., Song,Z.-G., Tian,J.-H., Zhang,Y.-L.,
            Liu,Y., Zheng,J.-J., Dai,F.-H., Wang,Q.-M., She,J.-L. and Zhu,T.-Y.
  TITLE     A novel coronavirus associated with a respiratory disease in Wuhan
            of Hubei province, China
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 30473)
  AUTHORS   Zhang,Y.-Z., Wu,F., Chen,Y.-M., Pei,Y.-Y., Xu,L., Wang,W., Zhao,S.,
            Yu,B., Hu,Y., Tao,Z.-W., Song,Z.-G., Tian,J.-H., Zhang,Y.-L.,
            Liu,Y., Zheng,J.-J., Dai,F.-H., Wang,Q.-M., She,J.-L. and Zhu,T.-Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JAN-2020) Department of Zoonoses, National Institute
            of Communicable Disease Control and Prevention, Chinese Center for
            Disease Control and Prevention, Changping Liuzi 5, Beijing 102206,
            China
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Hensley Lab @scottehensley.bsky.social · 05/01/2025
“The beauty of mRNA is the ability within a moment’s notice to change the vaccine.” time.com/7203820/h5n1...
time.com
Scientists Are Racing to Develop a New Bird Flu Vaccine
The most promising approach uses mRNA.
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
BK. Titanji @boghuma.bsky.social · 05/01/2025
The Outbreak of human metapneumovirus in China has caused a bit of a stir . It is not a novel virus but seems to be causing a significant outbreak coinciding with the winter. HMPV, was discovered in 2001 in the Netherlands. www.newsweek.com/human-metapn...
newsweek.com
HMPV: China's new virus outbreak explained
As reports of a new virus outbreak circulate, here is everything you need to know about human metapneumovirus (HMPV).
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Magda Kopczyńska @mgkopczynska.bsky.social · 27/12/2024
Do you know where transcription of a gene actually stops? Hint: it is not the annotated gene end. In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵 academic.oup.com/nar/advance-...
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 04/01/2025
This looks like it could be very useful! www.biorxiv.org/content/10.1...
biorxiv.org
A generative framework for enhanced cell-type specificity in rationally designed mRNAs
mRNA delivery offers new opportunities for disease treatment by directing cells to produce therapeutic proteins. However, designing highly stable mRNAs with programmable cell type-specificity remains ...
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 02/01/2025
Case report of 13 year old in British Columbia with H5N1 infection. Progression in one day from left-sided pneumonia to complete lung involvement (see chest x-rays) www.nejm.org/doi/full/10....
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 31/12/2024
Cool paper on broadening anti-influenza immune response to vax: - human data: twins, newborns, & tonsil organoid; & mouse data - Host genetics > original antigenic sin - Covalent coupling of diverse HAs decreases anti-HA antibody strain bias, probably via T cell help www.science.org/doi/pdf/10.1...
science.org
Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses
The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the...
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Flo Débarre @flodebarre.eurosky.social · 30/12/2024
Five years ago (Monday 30 Dec 2019), a turning point: the news of an outbreak in Wuhan spread on messaging apps, social media (Weibo, then Twitter), and got out of China, culminating with a ProMED alert sent to the international medical community on 30-31 Dec. ▫️1/
screenhot of the "red letter" document (details in the next posts)screenshot of the documents that spread on social media (more details below)
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Daniel Hurdiss @danielhurdiss.bsky.social · 27/12/2024
I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant. If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch! Application deadline: January 19th. Please share with your networks 🙏 Job link: tiny.cc/7v33001
tiny.cc
Postdoctoral Researcher in Structural Virology
This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Luca Pinello @lucapinello.bsky.social · 23/12/2024
1/ 🎄 What’s the best gift under the tree for a computational biologist? 🎁 A new experimental assay that refines our view of gene regulation: ACCESS-ATAC! This creative idea from Richard Sherwood was developed collaboratively between his lab and mine. #Genomics www.biorxiv.org/content/10.1...
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
BK. Titanji @boghuma.bsky.social · 21/12/2024
You don't say... The price of eggs will define 2025. I am calling it 😏 www.theguardian.com/us-news/2024...
theguardian.com
Egg prices soar as bird flu takes toll on US hen flock
Average price of eggs rose nearly 30 cents since October, with egg production down 4% from prior year
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 19/12/2024
Thomas Pindani Nyalile defended his Ph.D. thesis today: "Regulation of HIV-1 gene expression, provirus reactivation, and replication dynamics by EIF3H" Congrats Dr. Nyalile!!! Next Spring he'll be heading back to Tanzania to do some molecular biology:
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 18/12/2024
It is a first such case in the US, and of course scary, especially for the patient, but not a harbinger of a change in the virus. The person had exposure to sick birds. This is not infection with the dairy cow virus. www.cdc.gov/media/releas...
cdc.gov
CDC Confirms First Severe Case of H5N1 Bird Flu in the United States
December 18, 2024-- A patient has been hospitalized with a severe case of avian influenza A(H5N1)
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 15/12/2024
We discovered the source of the super high tech multicolored drones: Veggie Galaxy on Mass Ave near MIT (so obvious once you think of it)
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 14/12/2024
~40 non-human primates have their own SIVs/lentis/immunodef viruses. For ex, SIVsyke’s monkey, or SIVmandrill, all structurally similar to HIV-1
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Eddie Holmes @eddieholmes.bsky.social · 14/12/2024
The ICTV Lentivirus classification is flawed. Lentivirus humimdef1 (HIV-1) is not monophyletic (i.e. multiple jumps), nor is Lentivirus simimdef (SIV), and whereas HIV-1 has a single host and originated quite recently, SIV infects diverse primate species and is 1000s of years old. AKA inconsistent.
ictv.global
Genus: Lentivirus | ICTV
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Flo Débarre @flodebarre.eurosky.social · 05/12/2024
Here is why it is incorrect to blame the US response to the #H5N1 outbreak in dairy cattle for the human case in British Columbia: they are unrelated. H5N1 is diverse, and the genotype involved in the dairy cattle outbreak is not the same as the one collected in BC nextstrain.org/avian-flu/h5...
phylogeny of H5N1, with the cattle outbreak and the BC case highlighted: they belong to different branches of the tree
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Katy Stephenson @kstephensonmd.bsky.social · 12/12/2024
Agree! Huge scientific breakthrough - now we need global access to see the real change happen!
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 13/12/2024
Video recording of 2024 MassCPR Symposium is online Yoshihiro Kawaoka, Eva Harris, JJ Stone, David Bean, Shira Weingarten-Gabbay, Wanyu Li, Milky Abajorga, Erika Weiskopf UMadison/Tokyo, Berkeley, UMass, Harvard, Tufts, Boston Univ, MIT, Broad masscpr.hms.harvard.edu/masscpr-symp...
masscpr.hms.harvard.edu
2024 MassCPR Symposium | Massachusetts Consortium on Pathogen Readiness
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Laurence Ettwiller @ettwiller.bsky.social · 09/12/2024
www.biorxiv.org/content/10.1... Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 10/12/2024
Congratulations Dr Victoria Hogan, shown presenting her PhD thesis acknowledgments, @bostoncollege.bsky.social mentor Welkin Johson looking on. She discovered that the immunosuppressive domain of gammaretroviral type Envs stabilizes a transient conformational state required for host cell entry.
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Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 02/12/2024
1. #Flu update: #CDC posted FluView today, for the week ending Nov. 23. It shows that though flu activity is still relatively low, the season is starting. The crosscountry travel & multigenerational gatherings over Thanksgiving will likely have amped transmission up further.
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zeynep tufekci @zey.bsky.social · 29/11/2024
We’re entering flu season with bird flu raging among US dairy cattle: ~third of CA herds infected. The danger is flu viruses have a trick: they can swap segments —one farmworker co-infected by human and avian flu— to cause pandemics. We may get lucky. I hope so. 🎁🔗 www.nytimes.com/2024/11/29/o...
nytimes.com
Opinion | A Bird Flu Pandemic Would Be One of the Most Foreseeable Catastrophes in History (Gift Article)
It’s not too late for President Biden to give the U.S. a life-changing gift.
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François Mayer @francoismayer.bsky.social · 28/11/2024
Explore our December issue! 🔍Searching for avian influenza virus in Antarctica 🌡️Microbes against climate catastrophe ☕️Coffee shapes gut communities 💊Parkinson’s drug starves gut microbes of iron Read it here: www.nature.com/nmicrobiol/v...
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Literary Pearls @literarypearls.bsky.social · 18/11/2024
“We can disagree and still love each other unless your disagreement is rooted in my oppression and denial of my humanity and right to exist” James Baldwin
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Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Hiten Madhani @hitenmadhani.bsky.social · 24/10/2024
Check out our work that aims to decipher Cryptococcus neoformans on an global scale. 4300 knockout strains, 142 genetic screens, 6 in depth follow up stories (too many to summarize here, but rach is cool!). AlphaFold, AP-MS, microscopy, secretomics, mice, machine learning and more.
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Jeremy Luban 🧬🦠🔬🩺🎸🎻 @lubanlab.bsky.social · 24/11/2024
Been down so long (from social media), it (bsky) looks like up to me - Furry Lewis
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