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Reposted by Lesly Calderón

Journal of Experimental Medicine @jem.org · 04/02/2026

In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation. New study from Lesly Calderón @lesly-calderon.bsky.social, Meinrad Busslinger and colleagues @impvienna.bsky.social: rupress.org/jem/article/... #Hematopoiesis

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Reposted by Lesly Calderón

Vassilis Glaros @vassilisglaros.bsky.social · 06/01/2026

In this review we discuss our current understanding of how the diversity, maintenance, and function of the heterogeneous memory B cell compartment are shaped by the past and present ‘experiences’ of the individual cells that comprise it. www.nature.com/articles/s41...

nature.com

The multilayered identity of B cell memory - Cellular & Molecular Immunology

Cellular & Molecular Immunology - The multilayered identity of B cell memory

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Reposted by Lesly Calderón

IMP @impvienna.bsky.social · 29/01/2026

Plasma cells are the immune system’s antibody factories, producing the molecules that protect us after infection or vaccination. They originate from B cell. Yet how B cells make the switch to become plasma cells—and which genes control this transition—isn’t known. Researchers from the lab of

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Lesly Calderón @lesly-calderon.bsky.social · 29/01/2026

Our manuscript "In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation" was just published in the @jem.org, @rupress.org!!!

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Reposted by Lesly Calderón

IMP @impvienna.bsky.social · 29/01/2026

Plasma cells are the immune system’s antibody factories, and they originate from B-cells. Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:

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Reposted by Lesly Calderón

Rockefeller University Press @rupress.org · 28/01/2026

In @jem.org, @lesly-calderon.bsky.social et al. @impvienna.bsky.social describe an in vivo #CRISPR/Cas9 screening system for identifying novel regulators of B cell activation and plasma cell development in the context of the splenic microenvironment of immunized mice. rupress.org/jem/article/...

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