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Lorne Genome Conference, Australia

@lornegenome.bsky.social
102 followers 118 following 95 posts

The preeminent Australian conference on the organisation and expression of the genome www.lornegenome.org 14 - 17th February 2027

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Lorne Genome Conference, Australia @lornegenome.bsky.social · 24/09/2026
Abstract submission now open for Lorne Genome, held Sunday, February 14, 2027 - Wednesday, February 17, 2027 in the Lorne Theatre! Submit by Friday 13 November 2026 Prizes available for students, mid career and early career researchers. web.cvent.com/event/e57907...
web.cvent.com
Submissions - LORNE GENOME CONFERENCE 2027
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/09/2026
@lornegenome.bsky.social 2027 features Dr Michael Beer from Johns Hopkins University. He uses machine learning algorithms to discover how DNA encodes cell-specific enhancer activity. His work focuses on dynamic models of enhancer activation in cell state transitions and dysregulation in cancer.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 09/09/2026
Join us for the 48th Lorne Genome Conference, taking place from 14–17 February 2027 at the historic Lorne Theatre Lorne Genome 2027 will showcase an exciting scientific program coverin all things genomic. Early bird registration open now and abstract submission coming soon! lnkd.in/geaQ3xNE
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 30/04/2026
Lorne Genome 2027 will be held 14 to 17th February in Lorne Australia. Our invited speakers will include Karen Arndt, Neil Brockdorff, Laura Banaszynski and Fides Zenk.
Lorne Genome 2027 Poster: 14 to 17th February, at Lorne Australia. Background shows the coast off Lorne. Invited speakers include Karen Arndt, Neil Brockdorff, Laura Banaszynski and Fides Zenk.
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MACSYS @macsys.bsky.social · 20/02/2026
Honoured to have a member of our Intl Scientific Advisory Board in Australia this week. Prof Brenda Andrews from the Univ of Toronto (pictured right) delivered an invited talk at the Lorne Genome Conference and caught up with our Chief Investigator Traude Beilharz, president of the Conference Board.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 18/02/2026
That's a wrap for Lorne Genome 2026! Thanks to all the speakers for fascinating talks, poster presenters for hot of the press science, trade for making the experiments possible and of course all the attendees for great discussion. See you next year!
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 18/02/2026
This is great, remind us in 11.7 months!
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 18/02/2026
Congratulations to winners of the Lorne Genome Best Student Poster Prizes: Jessica Hawes, Sarah Berent, David Neville, Sandeep Kum and Andrea Daner!
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Martin Smith @martinalexsmith.bsky.social · 18/02/2026
Could @lornegenome.bsky.social be the MOST Aussie genomics conference?
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Steve Turner @sjturn.bsky.social · 17/02/2026
Last day of #Lornegenome. A great venue, cool talks and discussions. Learnt about diversification of mammalian genomes, inheritance of mutations and impact of mutagens, how TFs direct chromatin organisation and so much more. New collaborations, new projects, can’t wait til next year
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 18/02/2026
4/ uncharacterised transcripts in myeloid cells: still discovering new genes in the human genome🧬! Pathogen 🦠 stimulating meyloid cells revealed many alternate start sites particularlyin secreted proteins. So important to profile diversity of cell states www.biorxiv.org/content/10.6...
biorxiv.org
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 18/02/2026
3/ www.stemformatics.org : curated gene expression profiles w visualisations on a digital platform to support the research community: QC, data curation and normalisation approach is so important in ensuring data included is quality, particularly when combining cross platform data
stemformatics.org
Stemformatics
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 18/02/2026
2/ Christine showing some of her first Lorne Genome poster from 2003 and explaining what a microarray is for the new kids in the room.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 18/02/2026
2026 Winner of the Lorne Genome Julian Wells Medal: Christine Wells (no relation!) @stemcellsystems.bsky.social congratulations, well deserved!!
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Dr Andrew Lonsdale @lonsbio.bsky.social · 17/02/2026
Almost literally too late, but here is a feed for BlueSky to collate #LorneGenome posts that blends mentions of Lorne + Genome along with posts from @lornegenome.bsky.social Should still work next year though! bsky.app/profile/did:...
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Journeying back in time with Liran Carmel: reconstructing Neanderthal methylation. Found regions with different methylation to humans: genes that affect the face and voice.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Jennifer Zenker showing how pluripotent cells have unique microtubule organisation and its asymmetries direct fate decisions
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Kate Quinlan @katequinlan.bsky.social · 17/02/2026
We’ve been spoiled with lovely weather & quality science at @lornegenome.bsky.social this year, continuing this morning with Session 11 (Novel Approaches to Study the Genome) & then the Julian Wells Medallist presentation. Hope everyone has rested up after the dinner! See you 9am! #LorneGenome2026
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Lorne Genome Conference dinner with a few party crashers
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
And welcome to the conference dinner! 🍻
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
2/ Kalahari Meerkat Project has been running since 1993 w 4527 individuals across 12 gens. Found genes linking body mass and fitness with flow influenced by inbreeding.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Jenny Tung: Marrying evolutionary ecology and evolutionary genetics to link traits leading to differential survival with changes in allele frequency across generations using the cutest model organism: the meerkat
media.tenor.com
a group of meerkats are standing next to each other and looking at the camera
ALT: a group of meerkats are standing next to each other and looking at the camera
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Hazuki Takahashi: are RNA DNA 🧬 interactions cell type specific in humans? Develop RADICL-seq to map RNA-DNA interactions. Capture both cis and trans interactions, showing cell type specific interactions
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Transposable elements move DNA around genome, creating new genes BUT also a mutagen causing disease ☯️ Keith Slotkin has harnessed this mechanism to target DNA inserts to 🌿🫛 genomes. Have used synthetic biology to improve targeting from industry standard of 1% to >99% while reducing off target sites
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
90% Small Cell Lung Cancer🫁 is immune silent and evades immunotherapy , but there is plasticity between immune active / silent types. Marian Burr seeks to regulate this transition for improved SCLC survival.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Scientists everywhere: highly caffeine motivated!
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Key chats are being had in the queue! ☕️
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Austen Ganley does a random genome project: puts A.thaliana DNA into human cells. Gets transcription that is independent of A. Thailana genes.
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Reposted by Lorne Genome Conference, Australia
Dr Andrew Lonsdale @lonsbio.bsky.social · 17/02/2026
Can only tag @antobeck.bsky.social here on BlueSky to say that the #Illumina coffee cart is once again the quiet hero of #LorneGenome
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
@jennbrophy.bsky.social gives a beautiful talk uncovering the regulation of lateral root development, creating tools to engineer root branches 🌱
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Moving to human is a challenge for combinatorial genetics - more genes, more combinations, more 💲, more ⏰️! Using Hap1 haploid cells, chose 222 unique query genes to manage scale ➡️ 4M double mutants!
Comparison of yeast vs Human cells showing yeast is a simpler organisation for genetic studies
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Brenda Andrews: yeast 🥪 a fantastic systemic genetics, all viable deletion mutants are available. Using to map genetic interactions ➡️ link phenotype to genotype
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Thanks to Roche for bringing out @joepdel.bsky.social from Hartwig Medical to share his work using Roche-SBX for Paired Tumour–Normal Whole Genome Sequencing on their cohorts.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Up now Hongpei Li @singmolsci.bsky.social, winner of #lornegenome best student abstract! Telling us how p16 and polycomb interact to cause irreversible growth arrest and cell cycle exit.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Peter Cockerill's first Lorne Genome talk was in 1993! Back telling us about how chromatin priming allows faster reactivation of immune response genes in Memory T Cells.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 17/02/2026
Alexey Terskikh @perkinsinstitute.bsky.social shows us how epigentic change in the inner hair cells of the cochlear occur in a spatial fashion and is predictive of age.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
Petra Hajkova @imperialcollegeldn.bsky.social germ cells are depleted for lamins compared to somatic cells but pericentric heterochromatin still anchors to the periphery via H3K9me, in a similar fashion to ancestral 3D organisation that occurs in c. elegans.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
Ferdinand von Meyenn @imps-ethzurich.bsky.social is there metabolic memory im adipose tissue? Sampling from patients post bariatric surgery retain an obesity signature in their adipose cells post weight loss.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
Bing Zhu kicking off today by taking us through the mysteries of heterochromatin.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
Good morning Lorne! Hope you are enjoying another beautiful morning before we begin with our Epigentics and Chromatin session at 9am
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Kate Quinlan @katequinlan.bsky.social · 16/02/2026
It’s another beautiful morning in Lorne, with blue skies & kangaroos. Highs of 33 degrees & afternoon rain/thunderstorms are predicted, but it will be cool & dry in the @lornegenome.bsky.social Heritage Ballroom for Session 7: Epigenetics & Chromatin at 9am. Looking forward to it! #LorneGenome2026
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
Directed cell fate reprogamming is holy grail for regenerative medicine. Katherine Zyner created Refate to identify small molecules that can be used to convert cells between states. www.biorxiv.org/content/10.1...
biorxiv.org
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
Upon birth we have to switch from g to b globin 🩸 for effective oxygen uptake. Mitchell Weiss takes us through developmental regulation of globin genes and how insights have led to dev of therapeutic gene therapies for haemoglobinopathies. Challenge: personalised therapies are expensive
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
2/ psychiatric GWAS hits can hit genes with dozens of exons and many splice variants, which may be cell type specific. Turned TWAS (transcriptome wide association) into isoTWAS to identify isoform specific effects on trait. www.nature.com/articles/s41...
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
Michael Gandal genetic architecture of ASD and schizophrenia: GWAS studies have discovered 100s of loci influencing both disorders, current challenge is how do we interpret their role in disease? Colocalisation of psychiatric loci w cis EQTLs only explains 20%. What about isoforms??
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
2/ your choice of factorisation method matters! It influences interpretability and whether the factors highlight differences or similarities between samples. Want to know more? 👉 stephenslab.uchicago.edu/publications...
stephenslab.uchicago.edu
Stephens Lab
Matthew Stephens Lab at University of Chicago
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
Matthew Stephens introduces us to the wild world of matrix factorisation MF. Genomics has big datasets we want to simplify. What makes factors more interpretable? PCA can give different results to (non neg) NMF because it can have neg weights, but this makes PCA factors less interpretable than NMF.
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
Somatic mutations can drive disease, but hard to distinguish from technical error. Rhys Gillman introduces SCARCE: Single-Cell Analysis of Rare Clonal Events which blends scDNA seq with surface markers to find clonal variants in specific cell types www.biorxiv.org/content/10.1101/2025.10.30.685685v1
biorxiv.org
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
MND Motor Neuron Disease is associated with disregulated splicing caused by TDP43 dysfunction. Natalie Grima integrates long and short read data to identify aberrent splicing in the cerebellum dss.niagads.org/datasets/ng0...
dss.niagads.org
NG00178 - Multi-brain region mRNA-seq of sporadic ALS patients with pTDP-43 pathological staging - DSS NIAGADS
To access this data, please log into DSS and submit an application.Within the application, add this dataset (accession NG00178) in the “Choose a Dataset” section.Once approved, you will be able to log...
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Lorne Genome Conference, Australia @lornegenome.bsky.social · 16/02/2026
Andrew Lonsdale @petermaccc.bsky.social showcases LemonSplice 🍋 to try to answer the question of what does the mess of splice junctions 🧩 even mean? Shiny interface that visualises, quantifies novelty and links to published findings.
Andrew Lonsdale presenting at Lorne Genome 2026
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