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Long COVID Labs @longcovidlabs.bsky.social · 02/10/2026

In case you missed it: Invivyd announces topline results of the LIBERTY trial for VYD2311 - a new anti-COVID monoclonal antibody! VYD2311 led to fewer adverse events than mRNA vaccines - 56.5% vs 91.4%. What does this mean for approval? We break it down here: www.reddit.com/r/LongCovidT...

reddit.com

From the LongCovidTrials community on Reddit: Invivyd Conference Call Replay: Updates on LIBERTY VYD2311 Monoclonal Antibody Trials

Posted by Responsible_Cap_5289 - 1 vote and 0 comments

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Long COVID Labs @longcovidlabs.bsky.social · 28/09/2026

🚨Dr. Michael Scoma challenges the narrative that new cases of Long COVID are on the decline Dr. Scoma is a physician in NYC who treats patients with LC, MECFS, Chronic Lyme, and other complex chronic conditions. 1/

Plain text of tweet:

“Six consultations for Long COVID in the last two weeks - four of which are severe - developed in the last three to six months. I challenge the narrative that new cases are on the decline."

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C.H. Romatowski @chromatowski.bsky.social · 25/09/2026

New RCT of a valacyclovir, celecoxib, and nirmatrelvir/ritonavir combo for Long Covid starting at Mount Sinai. Phase 2, enrolling 150 people. Builds on this open-label case series: www.frontiersin.org/journals/imm...

markets.businessinsider.com

PridCor Therapeutics Advances Phase 2 SHIELD Study of a Combination Antiviral Regimen for Long COVID Toward Enrollment

TUSCALOOSA, Ala., Sept. 24, 2026 (GLOBE NEWSWIRE) -- PridCor Therapeutics, LLC, a clinical-stage biopharmaceutical company developing combinatio...

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Long COVID Labs @longcovidlabs.bsky.social · 24/09/2026

✨Dr. Nancy Klimas talks viral persistence and viral reactivation in Long COVID & MECFS✨👀 For those who may not know, Dr. Klimas is currently running a trip of sipavibart monoclonal antibodies at @NSUFlorida! youtu.be/9J-WO9dcoWk?... 1/

youtu.be

MECFS and Long COVID From Viral Reactivation to Treatment with Nancy Klimas, M.D.

YouTube video by Institute for Neuro-Immune Medicine

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Long COVID Labs @longcovidlabs.bsky.social · 21/09/2026

Gladstone Institute and UCSF researchers identify SARS-CoV-2 protein linked to lung damage in severe COVID-19 - and a possible treatment! 🫁 Super fascinating work here. ✨ gladstone.org/news/how-sin... 1/

google.com

Google Search

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Long COVID Labs @longcovidlabs.bsky.social · 15/09/2026

BioVie announces successful Phase II Clinical Trial Results for bezisterim for Long COVID! On today's webinar, the BioVie team, along with LC researcher @michaelpelusomd.bsky.social and patient advocate Ezra Spier, shared some really helpful insights. 1/ www.biospace.com/press-releas...

biospace.com

BioVie Announces Topline Results from Phase 2 ADDRESS‑LC Trial Evaluating Bezisterim for the Treatment of Neurological Symptoms Associated with Long COVID

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Jon Douglas @atranscendedman.bsky.social · 07/10/2025

Researchers at HSE University and the Russian Academy of Sciences found a 2022 COVID sample from an HIV+ woman in Kaluga that evolved for about two years inside her body. Clues suggest the virus persisted in her gut before reappearing in her airways. www.frontiersin.org/journals/cel...

frontiersin.org

Frontiers | A highly divergent sample from a nearly extinct SARS-CoV-2 lineage in a patient with long-term COVID-19

BackgroundAlthough COVID-19 is primarily an acute disease, there are cases of persistent infection, primarily in immunocompromised patients. It is hypothesiz...

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Long COVID Labs @longcovidlabs.bsky.social · 14/09/2026

New preprint confirms SARS-CoV-2 persistence in the GI tract of #LongCOVID patients - and confirms findings of previous studies! This study is really interesting for a number of reasons! 1/

Screenshot of figures from the paper demonstrating RNA and symptom levels over time

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Melissa Gira Grant @melissagiragrant.com · 02/08/2026

if you hated covid "lockdowns" try long covid

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Long COVID Labs @longcovidlabs.bsky.social · 24/08/2026

Open comment from our founder Rohan to the US FDA on Repurposed Medications for #LongCOVID 💊 👇 ***** This summer, the FDA has been requesting public engagement on how repurposed medications can be used for rare diseases, such as Long COVID 1/ www.longcovidlabs.org/post/fda-adv...

longcovidlabs.org

FDA advocacy on drug re-purposing | Long COVID Labs Blog

We submitted a letter to FDA advocating for greater patient access to re-purposed drugs, with specific recommendations.

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Long COVID Labs @longcovidlabs.bsky.social · 14/08/2026

UCSF & @polybiorf.bsky.social study finds evidence of viral persistence in the GI tract! This is huge news. Various studies have strongly suggested gut viral persistence, but to our knowledge this is the first one that’s truly documented it. 1/ www.bloomberg.com/news/article...

bloomberg.com

Long Covid Study Finds Gut Immune System Struggling to Clear Lingering Virus

The immune systems of people with long Covid may remain locked in a prolonged battle with remnants of the coronavirus, producing inflammation while failing to effectively eliminate its source, new res...

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Long COVID Labs @longcovidlabs.bsky.social · 13/08/2026

Next steps in the US FDA’s initiative on Repurposed Meds for Rare Diseases! Through Aug. 21st, they are accepting public comments addressing the following questions: 1/

Screenshot from Aug 5 presentation- questions are in next posts in this thread

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Long COVID Labs @longcovidlabs.bsky.social · 10/07/2026

Reminder: Deadline to Submit Comments to the FDA on Repurposed Medications is coming up on Monday, July 13! 💊 In case you missed it (or need the reminder!): In May, the US FDA put out a call for public comment on repurposed medications, specifically for rare and poorly understood diseases. 1/

Screenshot of announcement in Federal Register, found at https://www.federalregister.gov/documents/2026/06/11/2026-11691/drug-repurposing-for-unmet-medical-needs-request-for-information-extension-of-comment-period

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Long COVID Labs @longcovidlabs.bsky.social · 25/06/2026

Fascinating study examines role of herpesviruses in Long COVID brain fog - and a dementia drug may help! 🧠💊 This new study from Tokyo Jikei University School of Medicine shines a pretty powerful light on a potential cause of Long COVID brain fog, at least in a subset of patients. 1/

screenshot of article title and microscopic coronavirus photo

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Ruth Ann Crystal @drruth.bsky.social · 23/06/2026

Spike protein in the blood is not the answer. But if there was a way to test tissues or white blood cells, we may find SARS-CoV-2.

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Long COVID Labs @longcovidlabs.bsky.social · 23/06/2026

Not the answer we were hoping for, but very important to know: Spike protein in the 🩸is not a reliable biomarker for #LongCOVID 🦠

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Long COVID Labs @longcovidlabs.bsky.social · 23/06/2026

@npr.org highlights former White House Advisory Committee on #LongCOVID, disbanded by Trump administration 1/

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Long COVID Labs @longcovidlabs.bsky.social · 18/06/2026

New NIH press releases discusses a recent Cell paper, co-authored by Drs. Akiko Iwasaki and David Putrino. It's the third paper to verify that autoantibodies, when transplanted from human #LongCOVID patients into mice, can cause the mice to develop LC symptoms. 1/ www.nih.gov/news-events/...

nih.gov

Immune system may attack nervous system in some Long COVID patients

Researchers linked antibodies that attack the body’s nervous system to some neurological symptoms of Long COVID.

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Long COVID Labs @longcovidlabs.bsky.social · 08/06/2026

The @fda.gov has put out a Request for Public Comment on Repurposed Medications -- with a focus on rare diseases! This is a perfect time to chime in & raise awareness of #LongCOVID. A few people from our Subreddit have already submitted comments - check out what people are talking about here! 👇

reddit.com

From the LongCovidTrials community on Reddit: FDA is Requesting Public Comment on Repurposed Medications -- Deadline to Respond is this Thursday, June 11!

Explore this post and more from the LongCovidTrials community

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Danielle Beckman @daniellebeckman.bsky.social · 08/06/2026

Happy to share that, after a prolonged peer-review process, our review on the major Neuroinflammatory events in #LongCovid was accepted for publication in Translational Psychiatry by @natureportfolio.nature.com! Coming out soon, but preprint available here: www.preprints.org/manuscript/2...

Title of the review article: Understanding Neuroinflammation in Post-COVID-19 Syndrome: Biological Mechanisms, Diagnostic Biomarkers, and Therapeutic Prospects, by Daniel Martins ,Danielle Beckman,Marco Loggia,Alessandra Constanza,Alessandra Borsini

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Long COVID Labs @longcovidlabs.bsky.social · 04/06/2026

New Mass General Brigham study finds rate of Long COVID much higher than we think In this new study, researchers used an AI tool to track how many people tested positive and then later sought care for health problems linked to LC. The number came out at 16% - higher than most estimates. 1/

Screenshot of article title and COVID test

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Long COVID Labs @longcovidlabs.bsky.social · 31/05/2026

FDA approves Xocova (ensitrelvir) as post-exposure prophylaxis of SARS-CoV-2! www.fda.gov/drugs/novel-... 1/

fda.gov

Novel Drug Approvals for 2026

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Bill Adler @billadler.bsky.social · 17/05/2026

This is terrific. Japanese-made Ensitrelvir (Xocova) can prevent covid in people who have been exposed to the SARS-CoV-2 virus.

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Long COVID Labs @longcovidlabs.bsky.social · 29/05/2026

👉Finnish study finds Long COVID associated with changes in brain activity, rather than inflammation 🧠 This study showed some different results than what we typically see. Researchers did NOT find signs of increased inflammation in LC patients’ brains, compared to healthy controls. 1/

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Long COVID Labs @longcovidlabs.bsky.social · 20/05/2026

New study finds ensitrelvir (Xocova) and molnupiravir - but not Paxlovid- reduce Long COVID rates if taken during acute infection 💊 Here's a super interesting study out of Japan. Researchers gave one of the 3 above antivirals to patients during their acute COVID infection. 1/

Screenshot of article title and key points section

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Long COVID Labs @longcovidlabs.bsky.social · 14/05/2026

New @thelancet.com paper addresses ethical dilemmas in #LongCOVID research Should researchers: 👉Urgently funding clinical trials of potentially disease-modifying treatments 👉Continuing to build our understanding of the disease - which could let us more accurately subgroup patients? 1/

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Long COVID Labs @longcovidlabs.bsky.social · 08/05/2026

Amazing to see Men’s Health interview leading Long COVID researcher Dr. Michael Peluso of UCSF! Dr. Peluso explains why he believes we will someday have a cure for LC- and why he’s excited to get up every morning! ☀️🙏 www.menshealth.com/health/a7113...

menshealth.com

Millions of People Live With Long COVID. This Researcher Is on a Mission to Find a Cure.

Six years ago, Dr. Michael Peluso and his team launched a first-of-its-kind long COVID tissue bank. They’ve been working to understand the disease ever since.

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Long COVID Labs @longcovidlabs.bsky.social · 05/05/2026

Powerful op-ed from Dr. Robert Redfield, who was CDC director during the first Trump administration. As a physician, he says "Today, much of my medical practice is focused on helping patients afflicted with Long COVID." 1/ www.foxnews.com/opinion/inno...

foxnews.com

Innovation will provide solutions to Long COVID — the new chronic disease of our time

Long COVID affects up to 18 million Americans, yet research funding remains inadequate. Experts call for aggressive NIH investment in novel treatments.

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Miles W. Griffis @mileswgriffis.bsky.social · 30/04/2026

The latest episode of #StillHere is out now! We spoke with reporter Jamie Ducharme about her feature on the underreporting of #LongCOVID around the world. The episode also features advocate Mlindeni Gabela, on the stigma of the disease in South Africa. thesicktimes.org/2026/04/30/p...

thesicktimes.org

“People are dying because of the stigma”: Long COVID’s global underreporting problem - The Sick Times

Hosts Miles Griffis and Betsy Ladyzhets speak with health journalist Jamie Ducharme about why Long COVID is dramatically underreported globally, and hear from South African advocate Mlindeni Gabela ab...

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Long COVID Labs @longcovidlabs.bsky.social · 01/05/2026

Fascinating new research from @solveme.bsky.social What is going on with T cells in Long COVID and ME/CFS? 🤔👇 In this talk, researchers Dr. Liisa Selin, Dr. Ayano Kohlgruber, and Dr. Roshan Kumar discuss their newest work, arguing that dysfunctional T-cells are driving #MECFS and #LongCOVID. 1/

Screenshot from presentation explaining their hypothesis. Dysfunctional T cells clonally expand in response to a foreign or self antigen. This causes maladaptive reprogramming of CD8 T cells and disease due to impaired and/or sustained immunity

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Christophe Veltsos @drinfosec.bsky.social · 29/04/2026

Very interesting 🧵 by @longcovidlabs.bsky.social on XTwitter (didn't see it posted here yet): "Here's a great roundup on what the Long COVID Community has learned from recent clinical trials, from the always insightful @CortJohnson Definitely worth..." Full 🧵 threadreaderapp.com/thread/20492...

Here's a great roundup on what the Long COVID Community has learned from recent clinical trials, from the always insightful @CortJohnson Definitely worth a read! 🤔🧠

Cort draws several key points from these trials, including:

👉Short term antiviral treatments don't work. It's somewhat surprising after we've all heard the anecdotes of some patients improving on 5-10 days of Paxlovid. Unfortunately, trial results do not show a benefit here....

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Long COVID Labs @longcovidlabs.bsky.social · 24/04/2026

Important new paper from Steifman et al. looking at blood-based biomarkers of Long COVID in children and young adults (which quite possibly apply to adults too!). 🩸🦠 1/

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Long COVID Labs @longcovidlabs.bsky.social · 23/04/2026

Why gets Long COVID, and why? Why do Latinos appear to be at higher risk- and can environmental exposures increase risk? Important article from The Spokesman Review examines LC in Latino agriculture workers and questions the possible link to pesticide exposure 1/

Screenshot of title of article featuring photo of Dr Chopra in her office wearing a white lab coat

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Jon Douglas @atranscendedman.bsky.social · 23/04/2026

Mass General Hospital 84 participants study suggests long COVID may persist because spike related immune complexes overactivate neutrophils which release DNA traps that damage blood vessels and promote microclots sustaining inflammation. www.nature.com/articles/s41...

nature.com

Endovascular profiles linked to neutrophil activation in children and young adults with long COVID - Pediatric Research

Pediatric Research - Endovascular profiles linked to neutrophil activation in children and young adults with long COVID

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Long COVID Labs @longcovidlabs.bsky.social · 16/04/2026

New study examines the role of lymphocytes in Long COVID 🩸 Pretty exciting new preprint! Here, researchers examined the activity and function of lymphocytes - white blood cells that are part of the immune system. 1/

Screenshot of article title and abstract
https://link.springer.com/article/10.1186/s12967-026-08081-6

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Long COVID Labs @longcovidlabs.bsky.social · 13/04/2026

Can senescent cells be driving smell loss in Long COVID? 🧠 In a new paper, Tsuji et al. look at a new potential cause of LC smell loss - senescent cells in the olfactory mucosa. 1/

diagram from the paper showing how events in the acute infection lead to sustained olfactory abnormality in Long COVID

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Long COVID Labs @longcovidlabs.bsky.social · 06/04/2026

Invivyd's new monoclonal VYD2311 shown to be effective against emerging SARS-CoV-2 variants VYD2311 is Invivyd's new monoclonal antibody. It was designed for pre-exposure prophylaxis in immunocompromised adults, however they're also studying it for Long COVID as well. 1/

Screenshot of title and abstract from this paper: https://www.biorxiv.org/content/10.64898/2026.03.31.715419v1

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Long COVID Labs @longcovidlabs.bsky.social · 03/04/2026

Photobiomodulation (Red Light Therapy) for Cognitive Dysfunction in Long COVID 🧠 This new study found a red light device called the Vielight led to improvements in cognitive dysfunction, compared to placebo Why would this be effective? 1/

Screenshot of title, author info and background from this paper: https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/41768981

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Long COVID Labs @longcovidlabs.bsky.social · 30/03/2026

RECOVER Ivabradine Clinical Trial Fails to Show Benefit in #LongCOVID POTS Why is this? 👉 Could it be because study designed failed to account for different POTS subtypes? 👉Are patients' POTS symptoms caused by Microclots? More info here: 👇

reddit.com

From the LongCovidTrials community on Reddit

Explore this post and more from the LongCovidTrials community

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Long COVID Labs @longcovidlabs.bsky.social · 25/03/2026

Such important info here! Anecdotally, we know of many people who still developed LC even after taking Paxlovid, so the findings are disappointing - if not terribly surprising. However, this is great information to have. Now, we know to focus on other prophylactic treatments such as Metformin.

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Long COVID Labs @longcovidlabs.bsky.social · 23/03/2026

Platelet-to-Lymphocyte Ratio as a Biomarker of Brain Metabolism in LC 🧠 This fascinating study out of Poland investigated whether there's a correlation between brain fog in Long COVID, and immune markers that can be measured in the blood. To measure brain fog, they assessed patients using: 1/

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Jon Douglas @atranscendedman.bsky.social · 17/03/2026

Monash and Bond University researchers reviewed 14 long COVID treatments (antivirals, metformin, IVIG, mAbs, etc) and found the evidence is still thin. Only 6 had any randomized trial data, and none had enough proof yet to guide treatment decisions. www.frontiersin.org/journals/med...

frontiersin.org

Frontiers | Candidate treatments for long COVID: a narrative review of expert and patient-driven priorities

ObjectiveTo map the existing evidence for candidate treatments for long COVID that were prioritised by clinicians and people with lived experience, and to ch...

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Long COVID Labs @longcovidlabs.bsky.social · 13/03/2026

New preprint shows spike protein persisting in the GI tract - and how it affects the environment around it 🦠 Wow! A lot to unpack here. This team performed gut biopsies and found spike protein in the GI tract of Long COVID patients. 1/ www.biorxiv.org/content/10.6...

biorxiv.org

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