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Laurie Parker

@llparker100.bsky.social
88 followers 102 following 56 posts

Chemical biLOLogist, proteomics enthusiast. MN 🔬🧪🧫 views expressed are my personal ones.

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Reposted by Laurie Parker
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 30/07/2026
We already do this and companies who want them are happy to pay for PhD student interns. Why do precious and limited NSF funds need to be deployed for this? Most PhD student pursue industry jobs anyways - that has always been true. Use NSF funds to support basic science that industry wont support!
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Reese Richardson @reeserichardson.bsky.social · 05/06/2026
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
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shauna @goldengateblond.bsky.social · 07/05/2026
happy 9th anniversary to the day we watched Zendaya fall madly in love with Tom Holland in real-time
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Gina Baucom @gbaucom.bsky.social · 14/04/2026
😱 Super excited to be named as a Guggenheim Fellow!! 😱
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Mina Kimes @minakimes.bsky.social · 10/04/2026
I can't stop laughing at this post. It's perfect.
A guy asking ChatGPT to review a series of fart sound effects and getting a serious kiss ass response that calls it atmospheric
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Laurie Parker @llparker100.bsky.social · 28/03/2026
Tell me you don’t spend a lot of time driving long distances without telling me you don’t spend a lot of time driving long distances 😂
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I-75 Scientist @flscitriguy.bsky.social · 24/03/2026
On NOFOs and funding. grants.nih.gov/news-events/...
grants.nih.gov
NIH’s Path to a Simpler Funding Opportunity Landscape | Grants & Funding
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snackerü @snackeru.bsky.social · 18/03/2026
It has gone under the radar, but the University of Minnesota has selected a new brand tagline: "Leave a Future" Ummm ... it kind of makes the old "Driven to Discover" tagline look like a work of genius. I've got another tagline to run by them: "Uff da" umarcomm.umn.edu/brand
University of Minnesota

Leave a Future
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Laurie Parker @llparker100.bsky.social · 07/03/2026
Yah. feels like the jackpot has already started.
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Reposted by Laurie Parker
Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 17/02/2026
We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling & machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. 1/4 Preprint: www.biorxiv.org/content/10.6... Models/data (UbiqCore website): dunbrack.fccc.edu/ubiqcore
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Melissa Nadia Viviana 🐸 @resistrebelrevolt.net · 18/01/2026
Today, Minneapolis had their annual Powderhorn Art Sled Rally. A community organized event that this time featured de-Icer sleds and bowling pins named for world leaders. A very Minnesotan way to protest ICE. 😍🙌🏻
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Laurie Parker @llparker100.bsky.social · 21/08/2025
I don’t know enough about this stuff to know what is relevant here but just noticed that when scrolling through the HHS doc…
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Laurie Parker @llparker100.bsky.social · 21/08/2025
The October 2025 doc says that (some part of to all of?) it does not apply to grants from NIH, refers to this link for the NIH Grants Policy Statement: grants.nih.gov/grants/polic...
grants.nih.gov
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Reposted by Laurie Parker
Science Magazine @science.org · 10/08/2025
The appearance of large language models caused a drastic shift in the vocabulary of academic writing, according to an analysis in #ScienceAdvances of more than 15 million biomedical abstracts published from 2010 to 2024. Learn more:
scim.ag
Delving into LLM-assisted writing in biomedical publications through excess vocabulary
Large language models (LLMs) like ChatGPT can generate and revise text with human-level performance. These models come with clear limitations, can produce inaccurate information, and reinforce existing biases.
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Drug Monkey @drugmonkey.bsky.social · 08/08/2025
www.nih.gov/about-nih/ni...
nih.gov
Statement on the retirement of Dr. Noni Byrnes
Dr. Byrnes has served as CSR Director since 2019.
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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 08/08/2025
Nice containerization of AlphaFold, Boltz, and Chai, and calculation of metrics (including our ipSAE score for protein-protein interactions). www.biorxiv.org/content/10.1...
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Jeremy Berg @jeremymberg.bsky.social · 07/08/2025
Well, this is a huge Executive Order power grab... www.whitehouse.gov/presidential... 1/3
whitehouse.gov
Improving Oversight of Federal Grantmaking
By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal
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Laurie Parker @llparker100.bsky.social · 01/08/2025
It looks like a giant’s weird arm hair
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Science Magazine @science.org · 31/07/2025
The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.
scim.ag
With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency
Republicans on spending committee push back against proposed reorganization and overhead cuts
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Gregg Gonsalves @gregggonsalves.bsky.social · 30/07/2025
Russell Vought wanted to shut down all extramural grants from NIH in this current fiscal year, putting stop to ALL research across the US. Someone in the White House had better sense. But Vought is a dangerous man, who will stop at nothing to destroy science in America. www.wsj.com/politics/pol...
wsj.com
Trump Administration Scraps Effort to Pause Health-Research Funding
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
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Drug Monkey @drugmonkey.bsky.social · 29/07/2025
This NIH grant Multi-Year Funding ploy really makes you wonder what equally obscure and equally harmful stuff Vought is advancing across all the other functions of federal government, doesn’t it?
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Gregg Gonsalves @gregggonsalves.bsky.social · 29/07/2025
This is just so screwed up.
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Science Magazine @science.org · 28/07/2025
Researchers’ chances of winning a grant from the National Institutes of Health have dropped under a new policy. scim.ag/4f7uew2
scim.ag
Odds of winning NIH grants plummet as new funding policy and spending delays bite
Funding multiyear grants up front will sharply cut number of investigators receiving awards
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Laurie Parker @llparker100.bsky.social · 24/07/2025
Hahah it helped explain to my lab how it means they will be able to fund way fewer projects moving forward.
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Laurie Parker @llparker100.bsky.social · 24/07/2025
💯
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Laurie Parker @llparker100.bsky.social · 24/07/2025
Where “you” in this scenario is the NIH institute leadership and your monthly rent is the annual budget for a given grant.
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Laurie Parker @llparker100.bsky.social · 24/07/2025
It’s like if your landlord made you escrow your full lease period’s rent upfront. You would not then have money available to you to buy other stuff that whole time. You’d have way less available for groceries and would have to get very austere in any spending choices you make going forward.
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Soragni:Lab @alice.soragnilab.com · 24/07/2025
This 4th percentile funding cutoff for the NCI is so very catastrophic. Assuming a 4th percentile payline corresponds to a ~5% success rate, it would take 27 grant submissions to have an 80% chance of getting just one funded. At the current submission cap of 6 apps as PI/year that means 4.5 years
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Laurie Parker @llparker100.bsky.social · 24/07/2025
🤮
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Jeremy Berg @jeremymberg.bsky.social · 22/07/2025
NIH staff are being required to fully fund ~ 50% of their grants. This means that all 4 years of an award will be paid out of this appropriation. This will help them get the appropriated funds spent, but will mean they can only fund (1/2 + 1/4*1/2) = 5/8 has many grants as they would have otherwise.
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Drug Monkey @drugmonkey.bsky.social · 24/07/2025
Multi-year funding at NIH: The Quickening drugmonkey.wordpress.com/2025/07/23/m...
drugmonkey.wordpress.com
Multi-year funding at NIH: The Quickening
I have apparently missed some major NIH moves that are related to my thoughts about the Multi-Year Funded Research Project Grant (RF1) mechanism. It turns out that this strategy of multi-year fundi…
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Drug Monkey @drugmonkey.bsky.social · 24/07/2025
"NIH has ..implemented a new policy requiring that at least one-half of the remaining funds for competing research project grants (RPGs) in FY 2025 be used to upfront fund RPG competing awards. Upfront funding provides the funding for all years of the approved project period .. from one fiscal year"
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Drug Monkey @drugmonkey.bsky.social · 24/07/2025
Talk about your grant lotteries. Earn a 4%ile for a chance at a four year award....or bupkis. whee.
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Laurie Parker @llparker100.bsky.social · 24/07/2025
The 4th percentile… JFC
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 19/07/2025
There is a rally on MONDAY at 4:30 PM to stand up for NIH. Please join. Many NIH employees signed the Bethesda Declaration, objecting to the destruction of NIH. The Trump NIH Director asked the signers to meet. The rally follows that meeting, in support. actionnetwork.org/ev...
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Laurie Parker @llparker100.bsky.social · 20/06/2025
Had such a good time at aps2025.org, so good to see everyone! A real community.
aps2025.org
APS2025 – Peptides Rising
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Laurie Parker @llparker100.bsky.social · 19/06/2025
💯
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Jeremy Berg @jeremymberg.bsky.social · 23/05/2025
I started reading DrugMonkey when I was NIGMS Director. I will impressed with his command of NIH policies and practices and his clear, direct voice to scientists and to NIH. We started the NIGMS Feedback Loop blog (the first IC director-written blog) in large parts because of his example. 1/n
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Laurie Parker @llparker100.bsky.social · 21/05/2025
Drugmonkey is one of the people who helped me feel not alone when I was starting out. NIH funding is a tough game (even tougher now?) but it’s normal for it to feel hard!
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Michael MacCoss @maccoss.bsky.social · 11/05/2025
This is the way we recommend everyone make targeted proteomics assays. We've been doing it this way for 6-7 years now but only recently got around to putting a manuscript together. We use it for everything from SRM to PRM. Great work by @deannaplubell.bsky.social
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Ed Yong is offline @edyong209.bsky.social · 10/05/2025
👇🏼👇🏼👇🏼
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Laurie Parker @llparker100.bsky.social · 07/05/2025
This all sucks so much
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Laurie Parker @llparker100.bsky.social · 28/04/2025
Eagle eared?
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 27/04/2025
The NIH firings, and the grant cuts that pushed out scientists at universities, have already had DEVASTATING effects on US science. Research labs are precious and fragile things. Taking one key person out can break it. ICYMI, we pub’d an essay on this: altnih4science.subst...
altnih4science.substack.com
It takes years to build a science lab
Productive science requires a great team, and that team develops together. That's one reason chaotic interference is dangerous for science.
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anil oza @aniloza.bsky.social · 21/04/2025
UPDATE: The NIH has made this move official — publishing the draft we reported on this morning www.statnews.com/2025/04/21/t...
statnews.com
NIH bans all future grants to universities with DEI programs or Israel boycotts
NIH prohibited the awarding of new grants to institutions that have DEI programs or boycott Israeli companies
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Matt Yousefzadeh @mattyousefzadeh.bsky.social · 18/04/2025
“Instead of cutting red tape, they are strangling grantees with it,”
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Laurie Parker @llparker100.bsky.social · 17/04/2025
lol was it down for you too or was that based on UMN’s outage today?
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Laurie Parker @llparker100.bsky.social · 07/04/2025
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Laurie Parker @llparker100.bsky.social · 07/04/2025
This guy is doing his best
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Laurie Parker @llparker100.bsky.social · 07/04/2025
Yes 🥩
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