New in Nature! 🐭 Lövestam et al. injects tau filaments from the brains of AD and CBD patients into WT mice and demonstrates propagation through prion-like templated seeding that results in disease-specific pathologic phenotypes and seed specific folding.
www.nature.com/articles/s41...
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Prion-like transmission of human tau strains in the mouse brain - Nature
Mouse experiments show that Alzheimer’s disease and corticobasal degeneration tau filaments retain their distinct structures during templated seeding, supporting strain-specific tau propagation a...
