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Lennart Schada von Borzyskowski

@lennartschada.bsky.social
586 followers 285 following 36 posts

Assistant Professor at the Institute of Biology Leiden | Microbial biochemistry, synthetic biology, environmental sustainability

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Reposted by Lennart Schada von Borzyskowski
CarboNcare @carboncare-project.eu · 28/07/2026
Hello! We are a new @scienceinnovation.ec.europa.eu project building bacteria that only grow by making methanol-based chemicals instead of releasing CO2. 🌬️🦠 📈 Follow our journey and learn more at carboncare-project.eu Eight partners, six countries, one goal: Fermentation 2.0. #microsky 🧪
Sixteen people standing together and posing for a picture under the shade of a tree at a university campus.
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 19/06/2026
It was time for a new group photo, now with 12 people from 8 countries. 😊 🇳🇱 🇩🇪 🇨🇳 🇮🇹 🇬🇷 🇧🇬 🇸🇮 🇺🇸
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 04/06/2026
Please share: we are looking for an experienced scientist to join the team of NeCEN, the Dutch facility for advanced cryo-electron microscopy here in Leiden. Detailed information about the position is available here: careers.universiteitleiden.nl/job/Cryo-EM-...
careers.universiteitleiden.nl
Cryo EM Scientist (IBL/NeCEN)
Cryo EM Scientist (IBL/NeCEN)
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 22/05/2026
Please share: Open PhD position We are hiring a PhD student to work on the biocatalytic depolymerization of new biopolymers. The PhD candidate will be supervised by @larsjeuken.bsky.social at the Leiden Institute of Chemistry, with me as co-supervisor. careers.universiteitleiden.nl/job/PhD-Posi...
careers.universiteitleiden.nl
PhD Position: Biocatalytic depolymerization of new biopolymers
PhD Position: Biocatalytic depolymerization of new biopolymers
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 19/05/2026
Methanol is an increasingly important single-carbon feedstock to facilitate the transition towards a circular bioeconomy. In our new paper, we engineered Methylobacterium extorquens to produce the polyketide phloroglucinol solely from methanol: www.sciencedirect.com/science/arti...
sciencedirect.com
Establishing and optimizing phloroglucinol biosynthesis from methanol in Methylobacterium extorquens AM1 via strain engineering and medium optimization
Methanol serves as an increasingly important single-carbon feedstock that may help to facilitate the transition towards a circular bioeconomy. The Alp…
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 07/05/2026
Genetically enhanced bacteria can potentially become an effective tool for bioremediation. The state of the field is nicely summarized in a Spotlight article appearing in @nature.com, to which I was glad to contribute some comments. Check it out here: www.nature.com/articles/d41...
nature.com
Are microbes the future of pollution clean-up?
Synthetic biologists are engineering bacteria to feast on oil, plastic and toxic chemicals.
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 09/03/2026
I am happy to share that a joint EIC Pathfinder Open project has been funded. The CarboNcare consortium will develop disruptive technology for the sustainable production of chemicals from methanol. cordis.europa.eu/project/id/1...
cordis.europa.eu
CARBON-EFFICIENT BIOPRODUCTION OF CHEMICALS FROM METHANOL | CarboNcare | Project | Fact Sheet | HORIZON | CORDIS | European Commission
A major challenge in carbon-based bioproduction is achieving high-yield conversion of carbon feedstocks—such as methanol—into target compounds, while avoiding carbon losses to biomass or CO2 emissions...
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 05/01/2026
Please share: I am hiring a postdoc that will work on enzyme characterization and engineering in the frame of a recently granted EU consortium project. Read all details here and apply until February 5: careers.universiteitleiden.nl/job/Postdoct...
careers.universiteitleiden.nl
Postdoctoral researcher on enzyme characterization and enzyme engineering
Postdoctoral researcher on enzyme characterization and enzyme engineering
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Reposted by Lennart Schada von Borzyskowski
C5 EU Project @c5-project.eu · 18/12/2025
Our team met at Córdoba to kick off our @horizoneu.bsky.social project last month! 🇪🇺 “It was a fantastic opportunity for everyone to dive into the plans for metabolic engineering of cyanobacteria.” Partners sharer their experience and roles in the C5 project. Thank you for hosting us @uco.es!
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 28/11/2025
Last week, I attended the kick-off meeting for our EU-funded C5 project in Cordoba, Spain. It was great to discuss our plans for the metabolic engineering of Cyanobacteria in detail with all partners, and I really enjoyed the visit to sunny Andalusia.
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Reposted by Lennart Schada von Borzyskowski
PLOS Biology @plosbiology.org · 27/11/2025
GlcNAc build-up acts as a key metabolic signal in #Streptomyces, but how does it triggers developmental responses? @gillesvanwezel.bsky.social &co show that the enzyme NagS dehydrates GlcNAc-6P into a reactive intermediate, triggering a toxicity-based checkpoint @plosbiology.org 🧪 plos.io/44pE08I
Top: (Top row) Sensitivity of S. coelicolor mutants to GlcNAc. Spores (5 × 105 CFU) of S. coelicolor M145 and its mutant derivatives ∆nagB, SMA11, ∆nagB∆nagS, ∆nagB∆nagSC (∆nagB∆nagS expressing nagS) and ∆nagB∆nagSE (∆nagB∆nagS with empty plasmid pSET152) were streaked on MM agar plates with 1% mannitol (Mann) and 1% mannitol plus 10 mM GlcNAc (GlcNAc). (Bottom row) NagS and its role in GlcNAc sensing. Spores of M145 and ∆nagS were plated on MM and R5 with 0, 0.001, 0.01, 0.1, 1, 5, 10, 20, 50, 100, 150, and 200 mM GlcNAc. Note that nagS mutants hardly respond to GlcNAc.  Bottom: Model for the metabolic control of development by GlcNAc and NagS. During late vegetative growth of streptomycetes, the old vegetative or substrate hyphae are degraded in a process of programmed cell death (PCD), to produce the nutrients required to build the aerial mycelium (see mycelial drawings on the right). Mycelial lysis results in breakdown of the cell-wall, leading to the accumulation of GlcNAc-6P, which is a major nutritional signal for the onset of development and antibiotic production. NagS converts GlcNAc-6P into 6P-chromogen I (denoted as X-Ac-6P), which in turn is deacetylated by NagA into a toxic metabolite (denoted as X-6P) that resembles ribose. The toxic metabolite promotes cell lysis, thus releasing more GlcNAc-6P that serves as substrate for NagS and NagA. A salvage pathway then switches off the toxic pathway again. For this, GlcNAc-6P is converted by NagA and NagB into Fructose-6P (Fru-6P), which enters the pentose phosphate pathway (PPP), thereby producing 6-phosphogluconate (6-PG), a metabolic inhibitor of NagS. Thus, production of toxic metabolites ceases and the transition to aerial growth can be initiated. Arrows with round ends represent inhibition, dashed arrow shows proposed activity.
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 21/10/2025
Recently, I had the pleasure of presenting our work at the first CO2FIX conference in Tianjin, China. It was great to see how seriously this research area is taken in China and how breakthroughs in research are rapidly moving towards large-scale applications in biotechnology.
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 08/07/2025
Please share: I am hiring a postdoc that will work on enzyme characterization and engineering in the frame of the EU consortium project C5. Read all details here and apply until August 10: www.universiteitleiden.nl/en/vacancies...
universiteitleiden.nl
Postdoctoral researcher on enzyme characterization and enzyme engineering
The Faculty of Science / the Institute for Biology is looking for a: Postdoctoral researcher on enzyme characterization and enzyme engineering Vacancy number: 15834   Project description We are hiring...
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Reposted by Lennart Schada von Borzyskowski
Johannes Rebelein @rebeleinlab.bsky.social · 03/07/2025
Great collaboration with @lennartschada.bsky.social on an #enzyme converting the #plastic component ethylene glycol and to a feedstock chemical for microbes. Offering new ways to use plastic biotechnologically. 🧪
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Reposted by Lennart Schada von Borzyskowski
Cameron Thrash @jcamthrash.bsky.social · 02/07/2025
Ecogenomics and functional biogeography of the Roseobacter group in the global oceans based on 653 MAGs and SAGs www.biorxiv.org/content/10.1... #jcampubs 🌊
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 01/07/2025
Ethylene glycol is widely used as monomer of the plastic PET. It is therefore highly relevant as sustainable feedstock for microbial biotechnology. In our new paper in @natcomms.nature.com, we characterize efficient enzymes for ethylene glycol oxidation: www.nature.com/articles/s41...
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 26/06/2025
I am happy to share that a joint EIC Pathfinder Challenges project has been funded. The C5 consortium will develop disruptive technology for the sustainable production of isoprene from carbon dioxide. Stay tuned for more updates and open positions. cordis.europa.eu/project/id/1...
cordis.europa.eu
Clever Combination of Synthetic Compartmentalization, Carbon Fixation and Compound Biomanufacturing | C5 | Projekt | Fact Sheet | HORIZON | CORDIS | European Commission
The C5 Pathfinder project aims to revolutionize the production of bio-based chemicals by leveraging synthetic compartmentalization and metabolic engineering within photosynthetic cyanobacterial system...
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Reposted by Lennart Schada von Borzyskowski
Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 01/06/2025
1/3 Although the issue of releasing GMOs for env bioremediation has been virtually absent of the mainstream scientific literature in Europe/US for >20 yrs, the topic has continued strong in Asia—alas in less fancy/visible journals. Time to revisit the subject in view of new global challenges 💪🏻!
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 19/05/2025
Genetically enhanced bacteria can potentially become an effective tool for bioremediation in the future. Recently, an exciting breakthrough study about an engineered strain of the marine bacterium Vibrio natriegens was published in @nature.com: www.nature.com/articles/s41...
nature.com
Bioremediation of complex organic pollutants by engineered Vibrio natriegens - Nature
A synthetic biology approach was used to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils, thereby addressing notable threat...
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 23/03/2025
@dirktischler.bsky.social is opening the @vaam-microbes.bsky.social conference 2025 at @ruhr-uni-bochum.de. Looking forward to three days of presentations, posters, and networking!
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 06/03/2025
Only one week left to apply for this exciting PhD position, supervised by @gillesvanwezel.bsky.social and me! Please apply if you are interested in microbial biochemistry and have a solid background in enzymes, metabolic pathways, and bacterial genetics. www.universiteitleiden.nl/en/vacancies...
universiteitleiden.nl
PhD aminosugar metabolism
The Faculty of Science / the Institute for Biology is looking for a :PhD Candidate , Aminosugar metabolism and control of growth and development in bacteriaVacancy number: 15487 PhD project descriptio...
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Reposted by Lennart Schada von Borzyskowski
Erwan Rivault @erwanrivault.com · 10/01/2025
NEW: 2024 has just been confirmed as the warmest year on record, and the first to breach the 1.5C threshold. We used a ridgeline (Joy Division inspired) chart to visualise daily temperature anomalies since 1940. 2024 clearly stands out with 100% of its days above 1.3C and 75% above 1.5C.
Ridgeline chart showing the distribution of global daily air temperature differences from the pre-industrial reference period (1850-1900), for every year between 1940 and 2024. Each individual year resembles a hill, shaded in a darker shade of red and further to the right for warmer years. The trend is clearly towards warmer years, with 2024 standing out as first year above 1.5C.
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Reposted by Lennart Schada von Borzyskowski
Brexit Bin 🇪🇺 🇬🇧 🇩🇪 @brexitbin.bsky.social · 05/01/2025
Here's the Chancellor candidate of the German Greens, Robert Habeck, stating what everyone needs to know. Namely that a strong EU is the best counterweight to authoritarians like Musk and Trump. Which is why they support those parties that want to weaken the EU. [with English subtitles]
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Reposted by Lennart Schada von Borzyskowski
Angel Goñi-Moreno @angelgm.eurosky.social · 04/12/2024
Synbio across environmental scales! By @ricardsole.bsky.social et al. doi.org/10.1021/acss...
doi.org
Synthetic Ecosystems: From the Test Tube to the Biosphere
The study of ecosystems, both natural and artificial, has historically been mediated by population dynamics theories. In this framework, quantifying population numbers and related variables (associate...
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Reposted by Lennart Schada von Borzyskowski
Paul Carini @uncultured.carinilab.com · 03/12/2024
Not all Bradyrhizobium fix N2! In fact, most that live in soil probably don’t. We isolated a bunch from Arizona soils and found none had N-fixing or nodulation genes. We report their genomes and phylogeny here in an accepted paper at access microbiology! www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
High-quality PacBio draft genome sequences of 17 free-living Bradyrhizobium and four related Nitrobacteraceae strains isolated from arid soils in the Santa Catalina Mountains of Southern Arizona.
Non-symbiotic Bradyrhizobium are among the most abundant and ubiquitous microbes in bulk soils globally. Despite this, most available genomic resources for Bradyrhizobium are derived from plant-associ...
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Reposted by Lennart Schada von Borzyskowski
Micah G. Allen @micahgallen.com · 02/12/2024
Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!
A screenshot of a paper on bioarxiv illustrating the lack of blue sky share button!
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Reposted by Lennart Schada von Borzyskowski
Itai Yanai @itaiyanai.bsky.social · 29/11/2024
Which one are you? Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics. –Peter Medawar
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Mike Jetten @msmjetten.bsky.social · 29/11/2024
The denitrification ability and #nitrogen metabolism pathway of aerobic #denitrifier Marinobacter alkaliphilus SBY-1 under low C/N ratios doi.org/10.1016/j.sc...
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Kat Toropova @kattoropova.bsky.social · 24/11/2024
Sign of the times, no more bluebird on the biorxiv engagement tab..
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SEVA Plasmids @sevaplasmids.bsky.social · 22/11/2024
🌐 We just joined Bluesky! SEVA is a free, open-access plasmid repository and an international standard supporting the synthetic biology community. Catch us here! #SynBio ⬇️ seva-plasmids.com
seva-plasmids.com
Home - SEVA plasmids - Standard European Vector Architecture
Standard European Vector Architecture 4.0 Welcome to the CNB-hosted database and material repository of standard and modular plasmid vectors for (de/re) constructing complex bacterial phenotypes ...
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Reposted by Lennart Schada von Borzyskowski
Calin Plesa @calin.bsky.social · 12/11/2024
Started creating a synthetic biology starter pack. Still missing many so reply here if I forgot you or someone else. go.bsky.app/SjfpxTK #synbio
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Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · 19/11/2024
We created a starter pack of the members of our Leiden Early Drug Discovery and Development (LED3) hub. Follow our scientists to hear more about their exciting science: go.bsky.app/EJByPDg If you are in LED3 and on bluesky, but not in here, please reply to this. Our Starter Pack includes: (1/3)
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Reposted by Lennart Schada von Borzyskowski
Altmetric @altmetric.com · 18/11/2024
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
docs.bsky.app
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
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APNet - Assistant Professor Network Netherlands @apnet.bsky.social · 18/11/2024
Join us in building a strong Network of Assistant Professors in the Netherlands! If you are an Assistant Professor or equivalent in the Netherlands, we invite you to join APNet, a vibrant community created by and for Assistant Professors across the Netherlands. ap-net.nl/register/
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 24/04/2024
How can lab automation, machine learning, and high-throughput screening methods be combined to speed up the enzyme engineering process? We address this question in a new article in Nature Communications, out today: www.nature.com/articles/s41...
nature.com
Automated in vivo enzyme engineering accelerates biocatalyst optimization - Nature Communications
Achieving cost-competitive bio-based processes requires development of stable and selective biocatalysts. In this Perspective, the authors propose an integrated solution combining growth-coupled selec...
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 12/03/2024
A tale of three regulators: in a new study, we investigated the regulation of glycolate metabolism in the bacterium Paracoccus denitrificans. These results help us to understand how bacteria make use of this highly abundant molecule. Now available as a preprint: www.biorxiv.org/content/10.1...
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Reposted by Lennart Schada von Borzyskowski
Stephan Hacker @stephanhacker2.bsky.social · 22/02/2024
If you are interested to learn about our research towards new targets for the antibiotics of the future, check out my eye-opener video. Thanks to the Leiden Institute of Chemistry, the Faculty of Science and the KNCV for making this possible. www.eye-openers.nl/en/seethecas...
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Roland Hatzenpichler @environmicrobio.bsky.social · 16/01/2024
Please share: Are you a data creator/user in #metagenomics or other #omics? We’re working on standards for fair data reuse and would like your feedback. We welcome contributions by scientists from all career stages. 5-min anonymous survey here: tinyurl.com/y5kwytpd
tinyurl.com
Survey: “A roadmap for fair reuse of public microbiome data”
This survey will inform a manuscript titled “A roadmap for fair reuse of public microbiome data”, the abstract of which and core figure (Figure 1) are included below. The manuscript in its current...
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Pablo Ivan Nikel @pabnik.bsky.social · 05/01/2024
Thrilled to share the pAblo·pCasso toolset for unconstrained cytidine/adenine-base editing in #bacteria led by Ekaterina Kozaeva w/Zach Nielsen & Manu Nieto-Domínguez @LabNikel @DTUBiosustain @NAR_Open #SynBio #OpenAccess #CRISPR academic.oup.com/nar/advance-...
academic.oup.com
The pAblo·pCasso self-curing vector toolset for unconstrained cytidine and adenine base-editing in ...
Abstract. A synthetic biology toolkit, exploiting clustered regularly interspaced short palindromic repeats (CRISPR) and modified CRISPR-associated protein (Cas
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 18/12/2023
I have served on the first Junior Editorial Board of mBio in the past two years. Now, as my term comes to an end, Elizabeth Draganova and myself have coordinated an editorial that summarizes our experience during this important program of ASM. journals.asm.org/doi/10.1128/...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 13/12/2023
Choline degradation in Paracoccus denitrificans: identification of sources of formaldehyde www.biorxiv.org/content/10.1101/202…
biorxiv.org
Choline degradation in Paracoccus denitrificans: identification of sources of formaldehyde https://www.biorxiv.org/content/10.1101/2023.12.12.567942v1
Paracoccus denitrificans is a facultative methylotroph that can grow on methanol and methylamine as
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Ákos T Kovács @evolvedbiofilm.bsky.social · 21/11/2023
Systems-wide analysis of the ROK-family regulatory gene rokL6 and its role in the control of glucosamine toxicity in Streptomyces coelicolor Appl Environ Microbiol by Chao Li et al from Gilles van Wezel journals.asm.org/doi/10.1128/...
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Diethard Mattanovich @dmattanovich.bsky.social · 01/11/2023
Fresh from the press: In this Nature Commun perspective paper we discuss microbial pathways to assimilate single carbon substrates, their feasibility and biotech applications to reduce greenhouse gas emissions. Big thanks to co-authors Simone Bachleitner and Özge Ata! www.nature.com/articles/s41...
nature.com
The potential of CO2-based production cycles in biotechnology to fight the climate crisis - Nature C...
The utilization of one-carbon assimilation pathways for bioproduction represents a promising direction towards a more sustainable bio-based economy. Here, the authors compare the thermodynamic efficie...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 01/11/2023
@lennartschada.bsky.social on Natural and synthetic biochemistry of Paracoccus denitrificans for sustainable applications #KNVMGMM
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Lennart Schada von Borzyskowski @lennartschada.bsky.social · 31/10/2023
The Cell Physiology course (BSc, first year) is getting settled for the first lecture. Well, if I can convince at least a few of the students that topics such as the TCA cycle or CO2 fixation are interesting and exciting, I will consider the course a success. 🙂
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