Leif Sieben @leif7ieben.bsky.social · 08/03/2026The biggest bottle-neck to my personal code productivity: The fact that OpenAI still hasn't pushed a Codex mobile app. 0130
Leif Sieben @leif7ieben.bsky.social · 29/12/2025My paper of the year is Andrew Gordon Wilson's "Deep Learning is Not So Mysterious or Different". I'll be thinking this year about what family of functions (support) combined with what prior over parameters (inductive bias) can actually well capture drug discovery data including activity cliffs. 0120
Leif Sieben @leif7ieben.bsky.social · 26/10/2025You learn a lot about the underlying system design of your apps when you run them in a low data environment. 000
Reposted by Leif SiebenElizabeth Wood, PhD @lizbwood.bsky.social · 22/09/2025A fundamental lesson of modern AI is that scale is essential: training bigger models on bigger datasets unlocks new capabilities. A fundamental lesson of AI engineering is that scaling up isn't trivial: it is not just a matter of spending more money and resources. 173
Leif Sieben @leif7ieben.bsky.social · 07/09/2025Strong Platonic Representation Hypothesis: the universal latent structure of text representations not only exists, but can be learned and, furthermore, harnessed to translate representations from one space to another without any paired data or encoders. 110
Leif Sieben @leif7ieben.bsky.social · 03/08/2025Got recommend this substack from Leash bio by a friend. I think this is a masterclass in how to correctly split the data if there ever was one. Respect your chemistry folks! open.substack.com/pub/leashbio...open.substack.comData contamination is all random forest needsHere's why we believe our Hermes prediction results are real 000
Reposted by Leif SiebenSimon Fisher @profsimonfisher.bsky.social · 28/07/2025Not sure who came up with "Manhattan Plot", but in 2014 I coined the alternative term "Nijmegen Plot" (inspired by the Dutch town where I live) to describe underwhelming results from our earliest genome-wide association scans of language/reading traits. 210921
Reposted by Leif SiebenAlex Selby-Boothroyd @alexselbyb.bsky.social · 28/07/2025Love these maps of "street-text sightings" in the Pudding's latest piece pudding.cool/2025/07/stre... 0239
Reposted by Leif SiebenSander Dieleman @sedielem.bsky.social · 28/07/2025Great blog post on rotary position embeddings (RoPE) in more than one dimension, with interactive visualisations, a bunch of experimental results, and code!jerryxio.ngOn N-dimensional Rotary Positional EmbeddingsAn exploration of N-dimensional rotary positional embeddings (RoPE) for vision transformers. 0192
Reposted by Leif SiebenKeyon Vafa @keyonv.bsky.social · 14/07/2025Can an AI model predict perfectly and still have a terrible world model? What would that even mean? Our new ICML paper (poster tomorrow!) formalizes these questions. One result tells the story: A transformer trained on 10M solar systems nails planetary orbits. But it botches gravitational laws 🧵 24114
Reposted by Leif SiebenGreg Landrum @greglandrum.bsky.social · 17/07/2025Today's #RDKit blog post is a heartfelt plea for clearer communication. greglandrum.github.io/rdkit-blog/p...greglandrum.github.ioPlease stop saying “The Tanimoto similarity is” – RDKit blogA simple tip to explain what you actually did 2316
Reposted by Leif SiebenMark Riedl @markriedl.bsky.social · 13/07/2025There is a new startup from China called Moonshot. The original “moonshot” was the Apollo Program. An AI based moonshot could be referred to as an “AI pollo” program. “ai pollo” in Italian means something like “to the chicken”. 2101
Leif Sieben @leif7ieben.bsky.social · 26/06/2025I was recently on a flight with free Wi-Fi for texting but nothing else. Jokes on them: I can use Llama through WhatsApp now … 000
Reposted by Leif SiebenGreg Landrum @greglandrum.bsky.social · 20/06/2025The new #RDKit blog post, inspired by a question from @valencekjell.com, looks at the impact of molecular size on similarity thresholds. greglandrum.github.io/rdkit-blog/p...greglandrum.github.ioThe impact of molecular size on similarity. – RDKit blogAn exploration of how molecular size influences fingerprint similarity. 3115
Reposted by Leif SiebenPierpaolo Morgante (He/His) @piermorgante.bsky.social · 04/06/2025Yay for @pschwllr.bsky.social and @mlederbauer.bsky.social (and all your co-authors who aren't on BlueSky yet) 🥳 This #dataset is a prime example of #GoodData, and it ties nicely with what @clarakirkvold.bsky.social and @grynova.bsky.social were talking about a few weeks ago in their #JournalClub 062
Reposted by Leif SiebenTeddy Zartler @quantumtessera.bsky.social · 13/06/2025I've got a joke about Osysseus. I got lost on the way to the punchline... 011
Reposted by Leif SiebenLeif Sieben @leif7ieben.bsky.social · 05/06/2025change my mind: bruot RIS to Bibtex converter is the best website ever built. www.bruot.org/ris2bib/bruot.orgOnline RIS to BibTeX converterThe simple RIS (EndNote) to bib (BibTeX) online conversion app. 001
Leif Sieben @leif7ieben.bsky.social · 09/06/2025If anybody out there working on antimicrobial resistance (AMR) and needs some motivation on this gloomy New England Monday. 000
Leif Sieben @leif7ieben.bsky.social · 07/06/2025I think the ranking of things which are hard to predict goes: 1. The stock market. 2. LaTeX figure placement. 3. The meaning of life. 010
Reposted by Leif SiebenMaarten Dobbelaere @maartendobbelaere.bsky.social · 06/06/2025Cheminformatics family businesses be like 041
Leif Sieben @leif7ieben.bsky.social · 06/06/2025One of the surprising things about working in a microbiology lab is that you become more worried about washing your hands before using the restroom rather than after. 100
Reposted by Leif Siebenshri @shrikhalpada.dev · 04/06/2025I think the thing I'm most excited to see over the next ~10 years of #dataviz is web-based content that interweaves long-form text and modular interactives. Not as heavy as scrollytelling and not as aimless as a dashboard, but something in between. This is what I was going for with the QR project! 3427
Leif Sieben @leif7ieben.bsky.social · 05/06/2025change my mind: bruot RIS to Bibtex converter is the best website ever built. www.bruot.org/ris2bib/bruot.orgOnline RIS to BibTeX converterThe simple RIS (EndNote) to bib (BibTeX) online conversion app. 001
Leif Sieben @leif7ieben.bsky.social · 28/05/2025You know volatility is going crazy when sitting down to write a PAC proof about the sampling efficiency of an active-learning algorithm feels like a therapy session. At least math hasn't changed over the past 12 months ... 021
Reposted by Leif SiebenAndrew S. Rosen @andrewrosen.bsky.social · 23/05/2025Not me accidentally typing `squeue` into the Facebook chat. 081
Reposted by Leif SiebenMartin Stoermer @martinstoermer.bsky.social · 16/04/2025Thought experiments that you have down the pub are in vino 011
Leif Sieben @leif7ieben.bsky.social · 16/04/2025Has anybody ever paused to think that the glass that is metonymically meant by “in vitro” is actually also just made of silicon and could just as well be called “in silico”? 230
Reposted by Leif SiebenChristian Odendahl @codendahl.bsky.social · 10/04/2025Do I really write "... reckons Deutsche Bank, a German bank"? 28933
Reposted by Leif SiebenEncephalophatass (Any pronouns) @encephalophatass.bsky.social · 03/04/2025It’s always “We launched these tardigrades into space!” “We froze them to absolute zero!” “We threw them into an erupting volcano!” Never “We took these tardigrades on a holiday. They’re getting tiny massages and sipping little umbrella drinks on the beach.” 241885495
Leif Sieben @leif7ieben.bsky.social · 26/03/2025One day ChatGPT is going to learn to use MorganGenerator ... not today though. 200
Reposted by Leif SiebenMartin Pacesa @martinpacesa.bsky.social · 23/03/2025If a protein unfolds and there is no one to measure the CD spectrum, did it really unfold? 2292
Leif Sieben @leif7ieben.bsky.social · 20/03/2025It's such a privilege to live in a time where I can fully pretend like the climate crisis isn't happening simply by living in constant existential fear about the replacement of all meaningful work by more powerful, intelligent systems. Oh and somebody said something about a recession? 020
Leif Sieben @leif7ieben.bsky.social · 18/03/2025I know Manus AI didn't hit the mark but with everybody rushing into agentic AI, I'm genuinely at the point where I'm wondering whether I need to get PhD applications out pre-singularity. Who still hires PhDs if they can have a 24/7 researcher which inputs a PI's command and outputs results/data? 120
Reposted by Leif SiebenPedro Beltrao @pedrobeltrao.bsky.social · 16/03/2025New blog post - State of the lab 12, yearly series on being a group leader in academia. This one reflects back on the transition from junior PI to a more established scientist www.evocellnet.com/2025/03/stat...evocellnet.comState of the lab 12 - Becoming an established scientistThis blog post is part of a (nearly) yearly series on running a research group in academia. This post summarizes year 12, the 3rd year afte... 23911
Reposted by Leif SiebenAlex Selby-Boothroyd @alexselbyb.bsky.social · 15/03/2025The New Yorker is reäppraising the internet age 2203
Reposted by Leif SiebenRachael Sirianni, PhD @docsirianni.bsky.social · 15/03/2025This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH 7072654610664
Leif Sieben @leif7ieben.bsky.social · 15/03/2025In 20-30 years time, I wonder whether my children will look back on 2024 or 2025 the same way that I look back on 1968. 110
Reposted by Leif SiebenThe Onion @theonion.com · 18/02/202587% Of Loud Crashing Noises Are Nothing, Report Top Experts From Other Room theonion.com/87-of-l... 273581391
Reposted by Leif Siebenlukelukeluke @lukelukeluke.bsky.social · 09/02/2025You have never felt relief like a homeless hermit crab the moment they’re safe inside a new shell 75239096
Reposted by Leif SiebenKatie Wilkinson @drkwilkinson.bsky.social · 09/02/2025Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/datawrapper.dwcdn.netEstimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is ImposedBased on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15% 14214129
Reposted by Leif SiebenEugene Vinitsky 🍒 @eugenevinitsky.bsky.social · 01/02/2025Ask an LLM to summarize your paper because some reviewer will for sure read your paper this way 3525
Reposted by Leif SiebenKosta Derpanis @csprofkgd.bsky.social · 01/02/2025The hottest new programming language is E̶n̶g̶l̶i̶s̶h̶ Mandarin #DeepSeek 092
Leif Sieben @leif7ieben.bsky.social · 29/01/2025Has anybody’s ChatGPT also been starting to use an uncommon amount of emojis? Is this meant to lure me back from Deepseek? 000
Reposted by Leif SiebenRandall Munroe @xkcd.com · 21/01/2025Chemical Formulas xkcd.com/3040 346255652044
Reposted by Leif SiebenShaun O’Boyle @shaunoboyle.bsky.social · 16/01/2025Why do I have to rent software? Why can't I just buy it? 0292