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Laura de Rooij

@lderooij.bsky.social
787 followers 479 following 26 posts

Principal Investigator at CeMM | Vascular Aging, Endothelial Cell heterogeneity & Single Cell Omics derooijlab.org

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Reposted by Laura de Rooij
Aging Science News @agingbiology.bsky.social · 23/08/2025
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis www.biorxiv.org/content/10.1...
biorxiv.org
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
Endothelial cells (ECs) are critical regulators of vascular function and exhibit specialized, organ-specific roles across tissues. During aging, these cells become dysfunctional, resulting in increase...
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Laura de Rooij @lderooij.bsky.social · 19/08/2025
🚨Preprint alert!🚨What happens to our blood vessels as we age? To begin answering this at the transcriptome level, we built the Human Aging Endothelial Cell Atlas (HAECA), profiling >375,000 endothelial cells from 12 tissues across adulthood. www.biorxiv.org/content/10.1... (1/9)
biorxiv.org
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Rae Radford @raeradford.bsky.social · 19/07/2025
#BookSky
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Manlio De Domenico @manlius.bsky.social · 19/07/2025
"our results indicate that academia pays a price by focusing attention and resources on superstars" Nice to see this supported by data analysis, now. H/T: @cxdig.bsky.social www.nature.com/articles/s41...
nature.com
The innovation trade-off: how following superstars shapes academic novelty - Humanities and Social Sciences Communications
Humanities and Social Sciences Communications - The innovation trade-off: how following superstars shapes academic novelty
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CeMM @cemm.oeaw.ac.at · 24/06/2025
🔬 As we near the end of #EquationsForLife, today we spotlight @ar-abdelfattah.bsky.social's Group! They use the #ReactionDiffussion equation to characterize the process of tissue organization and maintenance in physiology, and how disease disrupts it. 🔎 bit.ly/4ef2Pbe
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CeMM @cemm.oeaw.ac.at · 16/06/2025
We kicked off the week with Roger Kamm (@mitdeptofbe.bsky.social) for a #CeMMinar on brain neurovascular models & its applications to modeling drug & toxin transport. Thanks to Roger for the great insights & hosts @lderooij.bsky.social & @ar-abdelfattah.bsky.social
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Reposted by Laura de Rooij
CeMM @cemm.oeaw.ac.at · 05/06/2025
A very insightful Impromptu Seminar today at #CeMM by Kumar Sharma (@uthealthsa.bsky.social), hosted by our PI @ar-abdelfattah.bsky.social! His talk on spatial mass spectrometry & precision therapeutics offered powerful insights into disease mechanisms and inter-organ crosstalk. Thank you, Kumar!
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Reposted by Laura de Rooij
Project MOTION @crgmotion.bsky.social · 16/05/2025
🌐 Introducing MOTION WorkPackage 2 by @reibergerthomas.bsky.social 🌐 In this particular WP the team is focusing on decompensated cirrhosis.. #liver #PortalHypertension #clinicaltrails #dACLD 🔽 Find out more in the video below 📷🔽
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Reposted by Laura de Rooij
CeMM @cemm.oeaw.ac.at · 05/05/2025
Let’s kick off the week with #EquationsForLife! @lderooij.bsky.social’s group studies how #aging affects endothelial cells in blood vessels. Using #MurraysLaw & 3D “vessel-on-a-chip” models, they aim to decode & combat cardiovascular aging. 🔍 tinyurl.com/CeMMRR2024-d... #CeMMResearchReport2024
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Laura de Rooij @lderooij.bsky.social · 23/04/2025
🚨 Exciting Opportunity! 🚨 Join us on June 9th in Brussels for a satellite conference to the 4th MPS World Summit, where we will address advancements & challenges in #aging research using #microphysiological systems and #organoids. Sign up here: lnkd.in/dCu_yCBr
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Laura de Rooij @lderooij.bsky.social · 23/02/2025
🚨Job alert🚨! We are looking for a highly motivated research technician to join us in our quest to dissect the transcriptomic make-up and function of endothelial cells across the human body, using cutting-edge omics technologies, clinical samples, and vessel-on-chip models. Please share & apply! 👇
lnkd.in
CeMM hiring Laboratory Technician in Vascular Heterogeneity (m/f/d) in Vienna, Austria | LinkedIn
Posted 11:40:28 AM. The laboratory of Laura de Rooij at CeMM, the Research Center for Molecular Medicine of the…See this and similar jobs on LinkedIn.
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Laura de Rooij @lderooij.bsky.social · 06/01/2025
Only two weeks left to apply, don't miss out!! 👇
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Hongkui Zeng @hongkuizeng.bsky.social · 02/01/2025
Excited to share our single-cell study on aging mouse brain! We found 2,449 cell-type specific age-DE genes, and an aging hotspot in specific hypothalamic cell types involved in energy homeostasis, which show both decreased neuronal function and increased immune response. doi.org/10.1038/s415...
doi.org
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice - Nature
A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional chan...
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Laura de Rooij @lderooij.bsky.social · 19/12/2024
Looking for a fully funded PhD position in wonderful Vienna? The CeMM PhD program is now open for applications! 🎓 🥼 🧫 We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
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Anne Oeldorf-Hirsch @anneo.bsky.social · 10/12/2024
Is anyone else just *not interested* in using AI for their writing? All accuracy and morality aside, I just don't want to. I want every last word I put on a page to have flowed out from my own body. Maybe I'm romanticizing it, but I just can't see it any other way.
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Abdel Rahman Abdel Fattah @ar-abdelfattah.bsky.social · 07/12/2024
Our #TBI project got funded! Driven by what happens when forces are too much to handle, we will engineer tools to traumatize organoids and focus on #ECMatrix dynamics, #mechanobiology, and molecular-to-multicellular tissue organization. Happy to collaborate! Happening @ CeMM
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Reposted by Laura de Rooij
Tomàs Montserrat Ayuso @tmontsay.bsky.social · 03/12/2024
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8
bmcgenomics.biomedcentral.com
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
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Laura de Rooij @lderooij.bsky.social · 29/11/2024
The complications of SARS-CoV-2 infection highlight the key role of #endothelial functions in health and disease. Great perspective in light of acute and Long Covid, and strongly in line with what we previously speculated: doi.org/10.1161/CIRC...
doi.org
American Heart Association Journals
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Eric Topol @erictopol.bsky.social · 28/11/2024
Blood vessel wall (endothelial) inflammation as a key to multi-organ complications of Covid and #LongCovid @science.org science.org/doi/10.1126/...
science.org
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
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Mark A. Hanson @hansonmark.bsky.social · 19/11/2024
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on? direct.mit.edu/qss/article/... A 🧵 1/n #AcademicSky #PhDchat #ScientificPublishing #SciPub
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Science News @scinews.bsky.social · 25/11/2024
Atlas of the plasma proteome in health and disease in 53,026 adults. #Cell #medBsky #SciBsky #scisky #proteome These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com). Open Access www.cell.com/cell/fulltex...
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Abdel Rahman Abdel Fattah @ar-abdelfattah.bsky.social · 24/11/2024
@bioeng-talk.bsky.social is posting here as well! Speaking of moving to new places (🦋), in this episode, a bunch of us discuss why we moved to Europe to continue our academic careers. Tune in to hear about our experiences and what motivated us to make the leap.
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Reposted by Laura de Rooij
BrunetLab @brunetlab.bsky.social · 23/11/2024
Updated Aging Starter Pack!! People and labs interested in aging 😀 Let me know if you'd like to be added! go.bsky.app/5UXXaDA
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Abdel Rahman Abdel Fattah @ar-abdelfattah.bsky.social · 23/11/2024
Let the first post be about our lab website! Happy to announce it's up and running. Our vision of controlling tissue organization and probing its mechanics is rather magnetic 🧲⚙️🧫🧬! #mechanobiology 👉 www.abdelfattahlab.org
abdelfattahlab.org
Abdel Fattah Lab
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Laura de Rooij @lderooij.bsky.social · 23/11/2024
Excited to join the 🦋 community, and even more excited to share that the lab has its very own logo & website! 🖥️🔎 Visit us at derooijlab.org to explore our work, stay updated on ongoing projects, papers, and more!
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