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Laura Fedele

@lau-fed.bsky.social
143 followers 267 following 8 posts

👩‍🔬Neuroscientist interested in cellular excitability/in vitro models-often found patching sensory or autonomic neurons. Postdoc at WolfsonSPaRC, King's College London | iPSC-neurons | patch clamp | ion channels| neuro-cardiac interactions

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Reposted by Laura Fedele
Cell Physiology Workshop Liverpool @cpw-liverpool.bsky.social · 24/01/2026
The 41st Cell Physiology Workshop will take place in Liverpool UK, from 17-28th August 2026. 🧪🔬🫀🧠🐌🦑 Sign-up below to register your interest in attending, and receive all the important details and updates. 👇🏼 #ionchannels #neuroskyence
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Laura Fedele @lau-fed.bsky.social · 27/10/2025
Happy to share our new preprint doi.org/10.1101/2025... We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
doi.org
Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes
Peripheral parasympathetic ganglia lie adjacent to their target organs; their dysfunction contributes to diseases like atrial fibrillation. Due to their challenging accessibility for primary culture, ...
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Reposted by Laura Fedele
Cell Physiology Workshop Liverpool @cpw-liverpool.bsky.social · 27/08/2025
#CPW2025 is now over, but we're already planning for #CPW2026 🦑🧠🫀🔬 To receive updates & find out when applications open for next year's Cell Physiology Workshop in Liverpool, go here: forms.office.com/e/PTh5qMvmUM Please share the link with your electrophysiology trainees. 🙂
Group photo from CPW2025 in the teaching lab
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Reposted by Laura Fedele
Amy Lock @amy-lock.bsky.social · 20/08/2025
Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further! www.biorxiv.org/content/10.1... @denklab.bsky.social #fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
biorxiv.org
Single-cell RNA sequencing clarifies dermal fibroblast subset representation in vitro and reveals variable persistence of keloid disease-associated features
In vitro models of scarring and fibrosis are essential to improve our understanding of disease mechanisms and ultimately develop much-needed effective therapeutic strategies. This is particularly true...
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Reposted by Laura Fedele
RainbowLabCVS-UoL @rainbowlabuol.bsky.social · 15/08/2025
Cannot believe that week one of the @cpw-liverpool.bsky.social is nearly over! A brilliant week so far! Thank you to everyone who has contributed so far, especially to the @biologists.bsky.social for their funding of our 40th workshop!
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Reposted by Laura Fedele
RainbowLabCVS-UoL @rainbowlabuol.bsky.social · 15/08/2025
The @cpw-liverpool.bsky.social has completed the first week; another brilliant first week with an outstanding cohort of participants! Looking forward to week 2…after a few nights sleep!
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Reposted by Laura Fedele
Wolfson SPaRC @wolfsonsparc.bsky.social · 06/08/2025
Some scenes from this year's Work Experience event, where we hosted a group of A-Level students for a week and gave them a variety of demonstrations, hands-on experiments, and lectures.
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Laura Fedele @lau-fed.bsky.social · 29/07/2025
I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys
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Laura Fedele @lau-fed.bsky.social · 27/06/2025
Honoured to have presented at the super cool Ephys Club⚡😎👩‍🔬 and thank you for all the constructive comments!
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Reposted by Laura Fedele
Wolfson SPaRC @wolfsonsparc.bsky.social · 18/03/2025
Many thanks to @theorah.bsky.social who did a wonderful job as our comic artist and bringing Professor SPaRC to life!
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Laura Fedele @lau-fed.bsky.social · 27/02/2025
Super happy to share our work just published in @jphysiol.bsky.social led by Neda Mohammadi and a amaxing work by all the authors! We show that sympathetic neurons can enhance the maturity of stem cell derived cardiomyocytes structurally and functionally- exciting data for neurocardiac models!
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Reposted by Laura Fedele
Wolfson SPaRC @wolfsonsparc.bsky.social · 19/02/2025
Congrats to the team for their ongoing commitment to the IoPPN Research Culture Fund in their successful running of the CommuniTEA event on Guy's Campus! @lau-fed.bsky.social @juliavw.bsky.social ☕️ #CommuniTEA Learn more here: www.kcl.ac.uk/news/seven-p...
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Laura Fedele @lau-fed.bsky.social · 07/01/2025
These research models trump cards look so much fun!! Amazing work @comeflywithjo.bsky.social !!! #StemCells #STEMoutreach #neuroskyence
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