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Lara Goscé

@laragosce.bsky.social
359 followers 256 following 5 posts

Assistant Professor in Modelling at LSHTM, TB modeller

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Reposted by Lara Goscé
Katherine Horton @kchorton.bsky.social · 21/07/2026
Our new paper in @nathealth.nature.com shows that population-level #TB interventions are likely to have more meaningful impact on disease burden than interventions that only reach routinely diagnosed individuals or their households. www.nature.com/articles/s44... 1/7
nature.com
Global impact and cost-effectiveness of tuberculosis interventions - Nature Health
A modelling analysis at a global scale estimates that three interventions (vaccination, community-wide screening and prison screening programmes) could prevent more than 10% of tuberculosis cases betw...
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Lara Goscé @laragosce.bsky.social · 13/06/2026
Poverty is a major driver of TB.Conditional cash transfers combined with counselling improve pre-treatment loss to follow-up.In this economic analysis our modelling projections show that this intervention is cost-effective and can reduce incidence and mortality. www.sciencedirect.com/science/arti...
sciencedirect.com
Cost-effectiveness of conditional cash transfers with pre- and post-test tuberculosis counselling in South Africa: a modelling analysis
Tuberculosis (TB) disproportionately affects low-income populations due to socioeconomic barriers. Conditional cash transfers (CCTs) are promising str…
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Finn McQuaid @cfmcquaid.bsky.social · 18/11/2025
@lshtm-tbmod.bsky.social is offering multiple PhD opportunities through MRC LID, deadline 14 Jan. More details: mrc-lid.lshtm.ac.uk/applicants/ Projects include #1 TB & screening #2 TB & climate change #3 TB & vaccines #4 TB & influenza #5 TB & prevention @cmmid-lshtm.bsky.social @lshtm.bsky.social
mrc-lid.lshtm.ac.uk
Information for applicants - MRC London Intercollegiate Doctoral Training Partnership Studentships
MRC LID studentship information for applicants How to Apply Projects Studentship funding Studentship options Studentship...
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TB Centre LSHTM @tb-lshtm.bsky.social · 25/11/2025
Join us 📆 9 Dec ⏰ 12.45 @tb-lshtm.bsky.social seminar Free & Open to all @kchorton.bsky.social @richardwhite321.bsky.social @reinhouben.bsky.social @dopapus.bsky.social @laragosce.bsky.social @danieljgrint.bsky.social tinyurl.com/2s4y3jcd
tinyurl.com
Excerpts from Copenhagen: The UNION World Conference on Lung Health 2025
Each year, many LSHTM TB researchers participate in the UNION World Conference on Lung Health, the world's largest conference on TB and lung health. This year, the conference takes place in
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Reposted by Lara Goscé
Richard White @richardwhite321.bsky.social · 24/11/2025
Another successful "Intro to TB Modelling" course in Copenhagen at #WLHC2025. Over 70 joined to learn about TB modelling! Followed by the now-traditional TB Modelling and Analysis Consortium social, which was also very well-attended and a lot of fun.
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Finn McQuaid @cfmcquaid.bsky.social · 31/10/2025
Our framework that informed the @who.int TB & climate change policy brief out now in @lancetrespirmed.bsky.social, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.thelancet.com/journals/lan...
thelancet.com
Climate change and tuberculosis: an analytical framework
Climate change is likely to exacerbate a range of determinants that drive tuberculosis, the world's leading cause of death from a single infectious agent. However, tuberculosis is often neglected in w...
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Reposted by Lara Goscé
Matthew Saunders @mjsaunder.bsky.social · 28/10/2025
“Wow, I saw in the last GTB report undernutrition is much less important for TB than we previously thought” I hear you say… Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
thelancet.com
Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative
Undernutrition is a key driver of the global tuberculosis epidemic, increasing the risk of people developing tuberculosis disease and of poor outcomes in those who do.1 Each year, WHO publishes estima...
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chaelinkim.bsky.social @chaelinkim.bsky.social · 20/10/2025
When fluoroquinolone resistance status is unknown, empirical use of BPaLM (adding moxifloxacin to BPaL) is cost-effective as a replacement for BPaL even with high fluoroquinolone resistance levels! 🦠💊 doi.org/10.1371/jour...
doi.org
Impact of fluoroquinolone resistance on the cost-effectiveness of empiric treatment for multidrug- or rifampicin-resistant tuberculosis
The WHO recommends the bedaquiline, pretomanid, and linezolid (BPaL) regimen with the additional fluoroquinolone antibiotic moxifloxacin (BPaLM) for initial treatment of multidrug- or rifampicin-resis...
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Reposted by Lara Goscé
Katherine Horton @kchorton.bsky.social · 12/10/2025
Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries. bit.ly/4nbV492
medrxiv.org
A global analysis of patterns of tuberculosis exposure and transmission
Tuberculosis (TB) is a major public health concern and the leading infectious cause of mortality globally. The disease exhibits strong prevalence patterns by age and sex, but the implications of these...
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Reposted by Lara Goscé
Rein Houben @reinhouben.bsky.social · 07/10/2025
In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...
medrxiv.org
Do no harm - re-evaluating the risks of overtreatment in community-wide tuberculosis screening
Background Community-wide screening is a crucial strategy to end tuberculosis (TB), but a common concern is potential harm from overtreatment following false positive diagnoses. However, current refer...
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Reposted by Lara Goscé
Katherine Horton @kchorton.bsky.social · 05/09/2025
At a time when global resources for #TB research, development, prevention, and care are limited, which interventions should be prioritised in high burden settings? 📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n bit.ly/3V3vXth
bit.ly
The potential impact, cost and cost-effectiveness of tuberculosis interventions - a modelling exercise
Background While a range of interventions exist for tuberculosis prevention, screening, diagnosis, and treatment, their potential population impact and cost-effectiveness are seldom directly compared,...
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Reposted by Lara Goscé
NPR @npr.org · 10/07/2025
The State Department's decision to impose sanctions on Francesca Albanese, the U.N. special rapporteur for the West Bank and Gaza, follows an unsuccessful campaign to force her removal.
n.pr
U.S. issues sanctions against United Nations investigator probing abuses in Gaza
The State Department's decision to impose sanctions on Francesca Albanese, the U.N. special rapporteur for the West Bank and Gaza, follows an unsuccessful campaign to force her removal.
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Reposted by Lara Goscé
Democracy Now! @democracynow.org · 10/07/2025
Secretary of State Marco Rubio has imposed sanctions on Francesca Albanese, the U.N. special rapporteur on the occupied Palestinian territory. Albanese says the move is an effort to “distract” from the genocide in Gaza.
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Katherine Horton @kchorton.bsky.social · 02/07/2025
New systematic review led by @hannahrickman.bsky.social shows annual risk of Mycobacterium #tuberculosis conversion in men and women diverges during adolescence and remains higher among men throughout adulthood. www.thelancet.com/journals/lan...
The figure shows two graphs, both with age on the x-axis and separate curves for males and females. In the top figure, the y-axis shows prevalence of Mtb immunoreactivity; in the bottom figure, the y-axis shows annual risk of Mtb conversion. In both figures, the curves for males and females diverge from adolescence and remain higher for men than women through adulthood.
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Reposted by Lara Goscé
Katherine Horton @kchorton.bsky.social · 04/07/2025
In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials. doi.org/10.1016/S221... @lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
Figure 1. Estimated number of trial endpoints in the control group of a prevention-of-disease vaccine trial in a high disease-burden setting showing number of endpoints on the y-axis and time in months on the x-axis. For bacteriologically confirmed symptomatic tuberculosis disease endpoints only, we estimate 69 endpoints, and for combined bacteriologically confirmed asymptomatic and symptomatic tuberculosis disease endpoints, we estimate 151 endpoints. Scenario assumes symptomatic disease incidence before trial screening of 300/100 000 per year and following 10 000 individuals over 3 years. Prevalent symptomatic and asymptomatic tuberculosis disease are screened out in month 0 and are not trial endpoints. Active screening occurs every 6 months for both scenarios and participants self-presenting with symptoms suggestive of tuberculosis disease would also be investigated.
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Bill Gates @billgates.bsky.social · 04/07/2025
A study in the Lancet recently looked at the cumulative impact of reductions in American aid. It found that, by 2040, 8 million more children will die before their fifth birthday. b-gat.es/44wCCQO
b-gat.es
The Effects of Reductions in United States Foreign Assistance on Global Health
Background: The United States (US) has traditionally been the largest donor to health programs in low- and middle-income countries. In January 2025 almost all s
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Reposted by Lara Goscé
Bill Gates @billgates.bsky.social · 04/07/2025
The facts are simple and devastating: Aid cuts have already cost lives, and the number of deaths will continue to rise. Here’s the evidence. ​
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 20/06/2025
LSHTM's Director writes to UK Government about #Gaza public health catastrophe Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster: 👉 www.lshtm.ac.uk/newsevents/n...
Palestinians fleeing northern Gaza on 9 November 2023 amid Israel's bombardment and siege of the enclave, and intense fighting between the Israeli military and Hamas fighters in the north. Credit: Mohammed Zaanoun/TNH
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LSHTM TB Modelling Group @lshtm-tbmod.bsky.social · 28/05/2025
Can you believe it’s already been 25 years!? Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social! More info 👉 www.lshtm.ac.uk/newsevents/e...
lshtm.ac.uk
25th anniversary celebrations of the Introduction to Infectious Disease
Our special event will celebrate the 25th anniversary of the Introduction to Infectious Disease Modelling and its Applications course, delivered by the London School of Hygiene & Tropical Medicine
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Reposted by Lara Goscé
Finn McQuaid @cfmcquaid.bsky.social · 30/05/2025
TB & climate change: @who.int report out now, building on an analytical framework we developed to explore the intersections and implications for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.who.int/publications...
who.int
Tuberculosis and climate change: analytical framework and knowledge gaps
This report explores the intersection of tuberculosis (TB) and climate change, highlighting how climate-related challenges such as food and water insecurity, displacement, and disrupted healthcare acc...
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Reposted by Lara Goscé
Rein Houben @reinhouben.bsky.social · 27/05/2025
Amid all the bad news in Global Health, perhaps some good news? A first analysis on the risk of false positive diagnoses in community-screening for tuberculosis using Xpert shows our clinic-based data is likely (very) wrong and overestimates false positives by >80%: tinyurl.com/yfecute9.
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IDDjobs @iddjobs.org · 20/05/2025
Postdoc (London, UK) Position available in the world-leading tuberculosis (TB) Modelling group at LSHTM with @raclark18.bsky.social‬ @richardwhite321.bsky.social at LSHTM @lshtm-tbmod.bsky.social More details: iddjobs.org/jobs/2314
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Lara Goscé @laragosce.bsky.social · 10/04/2025
Climate-driven migration and displacement and their potential impact on TB in Latin America gh.bmj.com/content/10/4... @cfmcquaid.bsky.social @reinhouben.bsky.social @lshtm-tbmod.bsky.social
gh.bmj.com
Tuberculosis and the climate crisis in Latin America: a predicament of poverty, migration and displacement
Tuberculosis (TB) has long been associated with poverty and displacement, through food insecurity, overcrowding, poor living conditions and reduced access to healthcare, which significantly increase t...
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Reposted by Lara Goscé
Finn McQuaid @cfmcquaid.bsky.social · 21/02/2025
Climate change is likely to exacerbate determinants which drive TB, the world’s leading infectious disease killer. Commissioned by WHO, we developed an analytical framework outlining potential causal relationships between climate change and TB: medrxiv.org/cgi/content/... @lshtm.bsky.social @who.int
medrxiv.org
Climate change and tuberculosis: an analytical framework
Climate change is likely to exacerbate a range of determinants which drive tuberculosis, the world's leading infectious disease killer. However, tuberculosis is often neglected in wider climate health...
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Lara Goscé @laragosce.bsky.social · 20/02/2025
Three PhD opportunities in modelling at @lshtm.bsky.social and @ukhsa.bsky.social on: Homelessness/Housing and TB: shorturl.at/FJ57W EBV and cancers in the UK: shorturl.at/IRHJk Climate change and TB: shorturl.at/R7f50
shorturl.at
Modelling the cost-effectiveness of Epstein-Barr virus vaccination in England (UKHSA-LSHTM PhD scholarship) at London School of Hygiene & Tropical Medicine on FindAPhD.com
PhD Project - Modelling the cost-effectiveness of Epstein-Barr virus vaccination in England (UKHSA-LSHTM PhD scholarship) at London School of Hygiene & Tropical Medicine, listed on FindAPhD.com
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IDDjobs @iddjobs.org · 07/02/2025
PhD position (London, UK) Quantify the effects of climate change on TB with @cfmcquaid.bsky.social @reinhouben.bsky.social @laragosce.bsky.social at @cmmid-lshtm.bsky.social @tb-lshtm.bsky.social @lshtm.bsky.social More details: iddjobs.org/jobs/2253
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Lara Goscé @laragosce.bsky.social · 04/02/2025
New PhD opportunity at LSHTM @lshtm.bsky.social @cmmid-lshtm.bsky.social and UKHSA www.lshtm.ac.uk/study/fees-a...
lshtm.ac.uk
2025-26 UKHSA-LSHTM PhD Scholarship | LSHTM
The London School of Hygiene and Tropical Medicine (LSHTM) is pleased to invite applications for a 3-year full-time PhD studentship, starting in September 2025, held between the Faculty of
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Reposted by Lara Goscé
Alvaro Schwalb @aschwalbc.bsky.social · 06/01/2025
1/ 📢 In our new PREPRINT - tinyurl.com/2pmudzrk - we evaluate how symptom-agnostic, population-wide screening interventions could significantly reduce the TB burden in Viet Nam. These require a substantial front-loaded investment but yield lasting cost savings. 🧵 #Tuberculosis #TBSky
tinyurl.com
Potential impact, costs, and benefits of population-wide screening interventions for tuberculosis in Viet Nam: a mathematical modelling study
Background Population-wide screening may accelerate the decline of tuberculosis (TB) incidence, but the optimal screening algorithm and duration must weigh resource considerations. Methods We calibra...
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Lara Goscé @laragosce.bsky.social · 10/12/2024
Our ASCENT modelling paper on Digital Adherence Technologies (DAT) for TB treatment is now out in BMJ Global Health gh.bmj.com/content/9/12... DATs may have limited epidemiological impact but can reduce costs and have important budgetary implications. @cfmcquaid.bsky.social @lshtm-tbmod.bsky.social
gh.bmj.com
Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia
Background Digital adherence technologies (DATs) with associated differentiated care are potential tools to improve tuberculosis (TB) treatment outcomes and reduce associated costs for both patients a...
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Kate LeGrand @lekate.bsky.social · 17/11/2024
Reflecting on this year’s #TB #UnionConf2024 and am so inspired by the brilliant minds and groundbreaking research being done to combat this global health threat. Special shoutout to the TB Modelling Group @lshtm.bsky.social 🫁
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