Spatiotemporal manipulation of neural circuits relies on genetic tools which require recombinant expression of exogenous actuators. Bátora et al. show that localized covalent inhibition of endogenous NMDA receptors is sufficient to reprogram behavior. Their two-photon molecular tattooing approach enables persistent, region-specific modulation of neural circuits without genetic manipulation.

Faut-il permettre aux cyclistes de traiter les panneaux d’arrêt comme des cédez-le-passage ? Cette règle venue d’Idaho divise, mais les données scientifiques pourraient surprendre.

At excitatory synapses, glutamate activates receptors in the postsynaptic membrane including the AMPA receptor. Usually considered to be the fastest receptor in the brain, AMPA receptors can produce m...

Photopharmacology, which enables the precise optical control of endogenous receptor activity, represents a powerful approach in neuroscience. However, photochromic diffusible ligands often exhibit lim...

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Molecular Psychiatry - Grin2a knockout in adolescent dopamine neurons disrupts prediction error signaling and produces a phenotype relevant to schizophrenia

Brain activity is highly regulated by GABAergic activity, which can suppress neuronal excitability and synaptic integration. Tonic GABAergic conductan…