Nucleolar enlargement is a conserved hallmark of physiological and premature ageing, including Hutchinson-Gilford Progeria Syndrome (HGPS), a disorder caused by LMNA mutations that produce Progerin an...

TCF3::HLF fusion protein mediates 3D genomic interactions in t(17;19)-positive acute lymphoblastic leukemia

Gupta et al. showed that NPM1, a nucleolar granular component factor, mediates NAD association with the nucleolus. NPM1 binds NADs and recruits histone methyltransferase G9a to establish H3K9me2 repressive chromatin, revealing that the nucleolus functions not only as a scaffold for NADs but also actively contributes to their chromatin repression.

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

Nature Reviews Genetics - Barbadilla-Martínez et al. review recent progress in deep-learning-based sequence-to-expression models, which predict gene expression levels solely from DNA sequence....

Karpinska, Zhu and colleagues characterize the structure-function relationship of the genome during cellular differentiation and demonstrate a role for enhancer-promoter interactions in gene regulatio...

Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...

Without surveillance, errors in ribosome assembly can lead to the buildup of defective intermediates that impair protein production. Akers et al. developed a system to model faulty ribosomes in human cells and discovered that the protein ZNF574 targets these intermediates for degradation. Loss of quality control results in defective ribosome buildup that jeopardizes cellular homeostasis and organismal health.