iiinova — where your digital self keeps evolving

Reposted by Kyla Ost

Judith Behnsen @judith-behnsen.bsky.social · 03/09/2025

Excited to share our new publication, out today in Nature! www.nature.com/articles/s41.... @kanchanj.bsky.social led this fascinating fungal-bacterial interaction project. We are grateful for our wonderful collaborators Brian Peters and David Underhill.

nature.com

Commensal yeast promotes Salmonella Typhimurium virulence - Nature

Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.

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Reposted by Kyla Ost

American Society for Cell Biology @ascbiology.bsky.social · 22/08/2025

ASM, ASBMB, ASCB & FASEB are deeply disappointed in the Supreme Court ruling allowing cancellation of $800M in NIH grants, threatening labs, jobs, and early-career scientists. Stable funding is vital for U.S. science. Read more: www.ascb.org/society-news...

ascb.org

Statement on Supreme Court Ruling in American Public Health Association v. NIH - ASCB

The American Society for Microbiology (ASM), the American Society for Biochemistry and Molecular Biology (ASBMB), the American Society for Cell Biology (ASCB) and the Federation of American Societies ...

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Reposted by Kyla Ost

PLOS Biology @plosbiology.org · 23/05/2025

#Fungal infections are hard to treat due to #DrugResistance. @blakebillmyre.bsky.social &co use a high-throughput #TNseq system in #Cryptococcus neoformans to identify >1400 essential genes & reveal a role for #mitochondrial genes in #fluconazole sensitivity @plosbiology.org 🧪 plos.io/4dz3iVm

Schematic of TN-seq in C. neoformans. Top left: Transposon insertions (orange arrow) into nonessential genes results in viable cells. In contrast, insertions into essential genes will result in dead and nonrecoverable cells. Top right: TN-seq works by generating a library of cells where each cell has a single independent transposon insertion in a random location. As in A, those insertions into essential regions cause the cells to die and are nonrecoverable. As a result, the total library (bottom) is depleted in insertions in essential regions. Bottom: The Ac/Ds transposon was split into an Ac transposase and a Ds transposon containing a neomycin resistance marker. This Ds transposon was integrated into an intron of URA5 and the Ac transposase was integrated into the safe haven locus. The resulting stain is ura− and neomycin resistant. Upon initiating transposition via growth on galactose, the strain becomes URA+ and mutant at another locus (depicted here as YFG1).

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Reposted by Kyla Ost

Asiya Gusa @asiya-gusa.bsky.social · 18/04/2025

Excited to announce Duke’s inaugural Climate and Fungi Symposium May 16, 2025! Please register for in-person or virtual 🍄 mgm.duke.edu/about-mgm/se...

mgm.duke.edu

Fungi in a Warming World: Adaptations, Challenges, and Resilience | Duke Department of Molecular Genetics and Microbiology

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RedPen/BlackPen @redpenblackpen.bsky.social · 19/02/2025

A reminder in these hard times. #sciencestrong

Cartoon showing a woman looking in to a microscope saying "Whoaah!!!" The caption states "The best part of Science is knowing, for a moment, something that nobody else in the world knows"

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Reposted by Kyla Ost

Ivan Zanoni @lozanzi.bsky.social · 12/03/2025

#EveryCellIsAnImmuneCell! June Round &friends show @science.org that in early life bacteria & fungi cooperate to expand insulin producing β islets via macrophage infiltration & that recognition of commensal yeast cell wall can protects against diabetes in adults! www.science.org/doi/10.1126/...

science.org

Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development

Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disr...

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Reposted by Kyla Ost

The MRC Centre for Medical Mycology @mrccmm.bsky.social · 12/03/2025

Join us for this month's #MycoTalks with Rebecca Shapiro and Guilhem Janbon 📅Thursday 27 March 🕓16:00 GMT Register here: universityofexeter.zoom.us/webinar/regi...

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Kyla Ost @kylaost.bsky.social · 07/03/2025

Early life colonization with an understudied Candida species promotes long term metabolic health. This still blows my mind - congrats Jen and team! Thrilled to have played a very smal part (mostly as your fungal cheerleader)

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Reposted by Kyla Ost

Liz Ballou @balloulab.bsky.social · 30/01/2025

PhD studentship for UK citizens! Understand how Endosymbionts Impact Mucoralean Fungi Drug Resistance Profiles. These are devastating invasive fungal infections that need urgent research. Work with my team @mrccmm.bsky.social, @forestcita.bsky.social, and UKDSTL www.surrey.ac.uk/bbsrc-wessex...

surrey.ac.uk

BBSRC Wessex One Health (WOH) Doctoral Landscape Award | University of Surrey

17 PhD studentships for October 2025 start: Interdisciplinary approaches to Infection Biosciences to combat disease threats to human and animal health.

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Dr Bridget @drvalleyfever.bsky.social · 01/02/2025

Great summary of the history of progress. Let’s not go quietly back to the dark ages.

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Reposted by Kyla Ost

Lucy Xie, PhD (she/her) @lucyxie.bsky.social · 23/12/2024

Excited to share my postdoc work now on bioRxiv! www.biorxiv.org/content/10.1... We discovered a non-genetic drug-adapted state that emerges frequently in the the human fungal pathogen Candida albicans. 1/6

biorxiv.org

Stress-driven emergence of heritable non-genetic drug resistance

Drug resistance is the chief cause of treatment failure for therapies targeting chronic and infectious diseases. Whether the emergence of resistance is accelerated by environmental exposure to low lev...

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Reposted by Kyla Ost

Ivan Zanoni @lozanzi.bsky.social · 11/12/2024

#LocationLocationLocation! Gribonika, Belkaid &co shows @ Nature that skin colonization by Staph epi activates Langerhans cells driving Abs in lymph nodes, & also in skin autonomous lymphoid organs that independently produce Abs protecting against systemic infections! www.nature.com/articles/s41...

nature.com

Skin autonomous antibody production regulates host-microbiota interactions - Nature

Nature - Skin autonomous antibody production regulates host-microbiota interactions

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