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Kristen Naegle (she/her)

@knaegle.bsky.social
763 followers 890 following 48 posts

Associate Professor of Biomedical Engineering, Computational and Systems biology research of how cells use biochemical networks to make decisions.

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Reposted by Kristen Naegle (she/her)
Chrystal Starbird @drstarbird.bsky.social · 01/10/2026
And… I am SO excited to share the first research preprint from my group! In this paper we determined several cryoEM structures to visualize the entire cell-to-cell bridging complex formed by TAM receptor and ligand, bringing into 3D a common graphical depiction. www.biorxiv.org/content/10.6...
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Reposted by Kristen Naegle (she/her)
Ketan Joshi @ketanjoshi.co · 09/09/2026
"Oh, you're criticising data centres? But you USED A DATA CENTRE to publish your post??? Hypocritical much????" Time to put this fossil fuel PR inspired talking point to bed forever. Why the 'Mr Gotcha' gambit is wrong in two very important ways:
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Reposted by Kristen Naegle (she/her)
Jess McLaughlin, PhD (they/them) @jfmclaughlin92.bsky.social · 24/07/2026
"Hey Jess, why do you spend so much of the classroom time of your genetics course talking about ethics?"
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Reposted by Kristen Naegle (she/her)
Sholto David @sholtodavid.bsky.social · 21/07/2026
Today I'm posting a blog about another ridiculous antibody blunder. Dozens of papers in the senescence and ageing field have mistakenly used an antibody for E. coli β-galactosidase when trying to stain for the human protein with the same name. forbetterscience.com/2026/07/21/d...
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Reposted by Kristen Naegle (she/her)
Jeff Lewis @lewislab.bsky.social · 20/07/2026
Nice write-up of our latest paper: news.uark.edu/articles/82610 And could not have been done without the support of NSF and NIH.
news.uark.edu
New Study Finds Heat Shock Can Drive Changes in Protein Modifications
Research provides insight into how yeast cells respond to stressful conditions with implications for larger organisms that share the same proteins.
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Reposted by Kristen Naegle (she/her)
Mark Peifer (He, him) @peiferlabunc.bsky.social · 07/07/2026
One more week to submit comments on the proposed changes to Federal funding that would ditch peer review and other quality controls and let political appointees decide how to spend the taxpayer's dollars. Please look in the link with instructions 🧪
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Reposted by Kristen Naegle (she/her)
Drug Monkey @drugmonkey.bsky.social · 28/06/2026
“The biases do not disappear; they get encoded into the model and then laundered into outputs that feel objective because they are numerical. “
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Reposted by Kristen Naegle (she/her)
Drug Monkey @drugmonkey.bsky.social · 28/06/2026
“Ranking all life science preprints on a single scale simultaneously, across neuroscience, structural biology, bioinformatics, and plant biology, assumes a commensurability that does not exist.”
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Reposted by Kristen Naegle (she/her)
johnedwinmason @johnedwinmason.bsky.social · 17/06/2026
Very happy to see this new addition to our cityscape — a free little food pantry.* It's outside First Baptist Church on West Main. Charlottesville friends, please help me fill it up for our many neighbors who are in need.
The photo shows a cupboard the enclosed by doors with glass windows. It rests on wooden stakes and stand on a patch of grass in the shadow of a building.
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Reposted by Kristen Naegle (she/her)
Anna Dearman @annadearman.bsky.social · 11/06/2026
www.nature.com/articles/s41... Such an excellent explanation
nature.com
Polygenic risk scores are not genetic predispositions - Nature Human Behaviour
Nature Human Behaviour - Polygenic risk scores are not genetic predispositions
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Reposted by Kristen Naegle (she/her)
Livable Cville @livablecville.bsky.social · 07/06/2026
People shouldn’t have to die in order to convince their city that better bike/ped/ADA infrastructure is necessary. But unfortunately that’s often what it takes.
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Reposted by Kristen Naegle (she/her)
Reese Richardson @reeserichardson.bsky.social · 28/05/2026
Here's the repository where we're collecting everything that we've found: doi.org/10.5281/zeno...
doi.org
Problematic images in vendor antibody verification data
This repository hosts documentation of suspicious, apparently manipulated or otherwise problematic antibody verification data in the catalogs of laboratory reagent vendors. As of 28 May 2026, we have ...
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Kristen Naegle (she/her) @knaegle.bsky.social · 05/06/2026
I have another Abcam antibody to add to your list. We tried multiple times and could never see signal on Abcam PD1 pY463 and now I know why! Image contrast from their catalog shows deep manipulation. Our data is here (final figure) - easy method for pY ab validation www.biorxiv.org/content/10.1...
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Reposted by Kristen Naegle (she/her)
Erin Fogg says Free Link @criminalerin.bsky.social · 20/05/2026
Every time we hear about how genAI has pushed another teenager to suicide, another person into committing a mass shooting, or generated CSAM of school girls used to blackmail their schools, remember we were told that what we'd be hearing about is a cure to every cancer, and global poverty itself
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Reposted by Kristen Naegle (she/her)
uvaresearch.bsky.social @uvaresearch.bsky.social · 01/05/2026
New UVA School of Medicine research streamlines drug discovery for inherited diseases. Led by Xiaowei Hu and Ani Manichaikul, the tool is 24% more accurate and uses diverse data to ensure treatments benefit all ancestries ow.ly/6K6J50YRYQC
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Reposted by Kristen Naegle (she/her)
Mariko Bennett @nachoriko.bsky.social · 24/03/2026
I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.
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🎃 Killy Witches 👻 @tillybridges.bsky.social · 24/03/2026
it’s not hyperbole, JKR literally said support for HP is support for her transphobia and she uses the money she makes from it to TRY TO TAKE OUR RIGHTS AWAY if you watch that show please don’t ever speak to me again trans lives are more important than your fandom of a terrible human’s IP
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American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · 24/03/2026
As a child, @phosphotig.bsky.social dreamed of being an astronaut, but her curiosity led her to scientific research. Now, she leads her own lab at UNC-Chapel Hill, & studies oxidative stress to find better therapies for triple-negative breast cancer. #WomensHistoryMonth www.asbmb.org/asbmb-today/...
asbmb.org
Learning, leading and lifting others
Tigist Tamir’s journey from aspiring astronaut in Ethiopia to cancer researcher at the University of North Carolina highlights the power of mentorship, persistence and curiosity in shaping a scientifi...
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Kristen Naegle (she/her) @knaegle.bsky.social · 20/03/2026
Project Hail Mary was just as good as I hoped it would be. However, content warning for biologists -- at one point there is an unbalanced centrifuge. I just closed my eyes until it was over.
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Kristen Naegle (she/her) @knaegle.bsky.social · 28/01/2026
The NIH moving to only allowing 6 total applications per year will have a disproportionate effect on marginalized scientists.
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Reposted by Kristen Naegle (she/her)
Timo B. Roettger @timoroettger.bsky.social · 28/01/2026
"P-Hacking with one prompt" by Shigeto Kawahara. TL/DR: Ask LLMs to find a significant effect, and they will oblige. www.researchgate.net/publication/...
researchgate.net
(PDF) P-hacking with one prompt
PDF | This brief note reports a mini-experiment, which tested whether major AI systems (Gemini, Claude, and ChatGPT) readily perform p-hacking when... | Find, read and cite all the research you need o...
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Erin Reed @erininthemorning.com · 06/01/2026
1. Did you know that Girl Scouts has, for a long time, accepted trans girls and nonbinary scouts? Trans kids are under attack. Every year, I make a thread of trans and nonbinary girl scouts you can get your cookies from. Lets get our cookies from them this year in solidarity!
erininthemorning.com
2026 Trans Girl Scouts To Order Cookies From!
This year, consider ordering your Girl Scout cookies from a trans girl scout to make their day!
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Reposted by Kristen Naegle (she/her)
Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 05/01/2026
Once again, I implore media outlets to stop saying these are CDC decisions. These are changes being made unilaterally by RFK Jr. against the expert advice of CDC scientists. I note that RFK Jr. no longer recommends flu vaccine for kids in the midst of a horrible influenza year.
nbcnews.com
CDC overhauls childhood vaccine schedule to resemble Denmark in unprecedented move
The new U.S. guidelines recommend all children get vaccines for 11 diseases, compared with the 18 previously on the schedule.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 21/11/2025
Wow
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Leah Teague 🏳️‍⚧️ @leah.teague.bio · 19/11/2025
I agree with EVERY SINGLE ONE of these rules. I came to most of them on my own because I never had any mentorship for my mentorship. And despite being published in PLOS Comp Bio, they apply to EVERY undergraduate and masters student project.
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Reposted by Kristen Naegle (she/her)
BK. Titanji @boghuma.bsky.social · 23/10/2025
Marching and protesting is great but real action is even better. If you can afford it, find and donate to a local food pantry in your area. The families that depend on SNAP benefits could really use the support over coming weeks to months.❤️🫂 give.feedingamerica.org/SnP--N8F9EuA...
give.feedingamerica.org
Join me in ending hunger
I just donated to @FeedingAmerica to help make sure families and kids have the meals they need! http://feeding.am/givemeals
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Reposted by Kristen Naegle (she/her)
Solomon @solomonrmissouri.com · 12/08/2025
Hey guys... this is serious please go and opt out NOW!
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Denis Wirtz @deniswirtz.bsky.social · 11/08/2025
These are the most challenging times for early-career scientists and engineers. My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers. We found 437 of them. Download it freely here: research.jhu.edu/rdt/funding-...
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Kristen Naegle (she/her) @knaegle.bsky.social · 31/07/2025
Please give feedback. I know I'm considering the new NIH mandate that open access has to be immediately available, meaning that grantees are footing open access bills at journals to meet the mandate. That can mean $5-$12K a paper of taxpayers money.
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Kristen Naegle (she/her) @knaegle.bsky.social · 14/07/2025
No, no, this is all wrong. The quote is actually supposed to be "let them eat cake". Apropos of nothing, Happy Bastille day to all those who celebrate.
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Reposted by Kristen Naegle (she/her)
Chise @sailorrooscout.bsky.social · 12/07/2025
There are currently more kids in Texas with measles than there are transgender collegiate athletes in all of America. Guess which one they want you to focus on.
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Kristen Naegle (she/her) @knaegle.bsky.social · 02/07/2025
$123,536,510 of federally appropriated funding has been stolen from Virginia schools
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Reposted by Kristen Naegle (she/her)
Siva @sivav.bsky.social · 28/06/2025
On just one Friday the Supreme Court brought my citizenship into question and the Trump administration gutted my employer and possibly threaten my career. I could only write about one of those things. newrepublic.com/article/1973...
newrepublic.com
UVA President James Ryan Caved to MAGA—and They Forced Him Out Anyway
Ryan had not fought Trump on DEI and other matters. His forced ouster proves that no capitulation is enough.
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Reposted by Kristen Naegle (she/her)
W. Carson Byrd @wcbyrdphd.bsky.social · 28/06/2025
In the fallout of James Ryan resigning from UVA, @sivav.bsky.social provides a clear argument of what higher ed is facing & why capitulation will not save you. newrepublic.com/article/1973...
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jenntheflower @jenntheflower.bsky.social · 28/06/2025
thank you, @sivav.bsky.social, for putting a lot of what I’m furious about in plain language. newrepublic.com/article/1973...
newrepublic.com
UVA President James Ryan Caved to MAGA—and They Forced Him Out Anyway
Ryan had not fought Trump on DEI and other matters. His forced ouster proves that no capitulation is enough.
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Reposted by Kristen Naegle (she/her)
Chise @sailorrooscout.bsky.social · 25/06/2025
PLEASE SHARE 🧪‼️ Vaccination schedules on the CDC website have already started changing under RFK Jr. Scientific American has published a guide to the EVIDENCE-BASED vaccine recommendations in place BEFORE ACIP members were removed by the administration. www.scientificamerican.com/article/see-...
scientificamerican.com
Here’s Your Cheat Sheet for Vaccine Recommendations Backed by Science
These graphics will guide you through science-based vaccine guidelines for children and adults
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Kristen Naegle (she/her) @knaegle.bsky.social · 25/06/2025
So happy to see this work is out and I hope it helps people find their best lab fit!
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Reposted by Kristen Naegle (she/her)
Livable Cville @livablecville.bsky.social · 21/06/2025
Charlottesville is turning into an e-bike city! Great article from @nathanalderman.bsky.social on the @cvillecityhall.bsky.social e-bike voucher program, which is one piece of the city’s efforts to create a better transportation system. c-ville.com/citys-e-bike...
c-ville.com
City’s e-bike voucher program provides some extra pedal power - C-VILLE Weekly
UVA doctoral candidate T.C.A. Achintya needed a better way to get around. A new program from the City of Charlottesville made it happen. “I had contemplated buying a regular bike, since I don’t own a ...
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BWJones @bwjones.bsky.social · 08/06/2025
Almost all Nobel Prizes are awarded for work that is exploratory, or absolutely basic science with no obvious commercial or medical benefit. You cannot predict where advancements come from, so you have to invest in science and scientists. Targeted (corporate) science investment will never do this.
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Scott Delaney @scott-delaney.bsky.social · 19/05/2025
Grant freezes versus terminations feel different, but they have the same practical effect. We should start treating freezes as terminations, both of which can be undone by HHS / NIH whenever they want—or by court order if they refuse. They’re all illegal.
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Anna Kornbluh @annakornbluh.bsky.social · 18/05/2025
say it again: 4 million people work in higher ed, the largest employer in 10 states, second largest employer in 10 more, and in 60 of the 100 biggest cities ROI for NIH and NSF for local economies is conservatively 4x, often close to 10x demolishing higher education is economic sabotage
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Kristen Naegle (she/her) @knaegle.bsky.social · 14/05/2025
This is devastating for American science, health, technology, and the economy.
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Noam Ross @noamross.net · 13/05/2025
We updated the reporting form today to clarify that we're also collecting info on "stop-work orders, unexpected non-renewals, or effective termination through updated notice of award." grant-watch.us/submit-nih.h...
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Santiago Mayer @santiagomayer.com · 11/05/2025
We’ve become so desensitized to corruption that the Attorney General who spent years lobbying on behalf of Qatar approved a private jet gift from Qatar and it’s not even in the top 10 scandals of the week.
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 10/05/2025
“The results revealed that researchers who received renewals without a funding gap were less likely to switch research topics and investigate a wide array of subjects than were those in the control group, and they produced papers featuring newer or more unconventional combinations of ideas”
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Kristen Naegle (she/her) @knaegle.bsky.social · 08/05/2025
I heard the new pope is a math major. So that means he understands both sin and sin^-1 right?
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Kristen Naegle (she/her) @knaegle.bsky.social · 30/04/2025
It has been scientifically shown that all dogs can engage an anchor mode by which their effective weight is quadruple their normal weight.
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Kristen Naegle (she/her) @knaegle.bsky.social · 26/04/2025
For Charlottesville peeps, MAGA-endorsing businesses include Charlottesville Tire and Auto, First Free Coffee, The Gym, Start 2 Finish nutrition, and several contractors and photographers.
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Jen Bendery @jbendery.bsky.social · 26/04/2025
NEW: PublicSquare, a website that lets you search for businesses in your community that explicitly want you to know they endorse Trump/MAGA values, is backfiring as people use it to boycott those businesses. www.huffpost.com/entry/public...
huffpost.com
Website For MAGA-Friendly Businesses Backfires As People Use It For Boycotts
Social media posts about PublicSquare have gone viral as Trump critics use it to find companies not to support – the opposite of what the site was set up for.
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Alexios Mantzarlis @mantzarlis.com · 21/04/2025
Update: I have been able to confirm grants worth ~$6M were terminated but think the total may be as high as $94M. If you or your colleagues got a termination letter, considering responding to the form. You can do so anonymously.
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