Human neurodegenerative conditions such as Parkinson’s and Alzheimer’s Disease are characterized by the formation and deposition of toxic protein species which exacerbate neuronal dysfunction, impacti...

Author summary Malaria parasites, like all living organisms, need to regulate their proteins carefully to survive and grow. One important way they do this is through a process called ubiquitination, w...

Proteasome cleavage changes during infection to generate antibiotics.

Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Many intracellular bacteria secrete deubiquitinase (DUB) effectors into eukaryotic host cells to keep the bacterial surface or the enclosing vesicle m…

Nature Chemical Biology - Advanced E2-modified ubiquitin probes enable investigation of E2-selective ubiquitination in cells and the discovery of tyrosine ubiquitination as a modification occurring...

Shen and Yin developed a technology named FUSEP to profile the E2-specific ubiquitome that makes use of a fusion between E2 and ubiquitin carrying a R74G point mutation, which leaves an LGGG remnant f...