biorxiv.org
Beyond benchmark accuracy: machine-learning turnover-number predictors require system-level validation
Enzyme turnover numbers ( k cat) are essential for kinetic models and enzyme-constrained genome-scale metabolic models (ecGEMs), but measured values are sparse and therefore increasingly estimated usi...
![[Scene is ANCIENT GREECE - where SOCRATES and PLATO and others are sitting round, thinking]
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SOCRATES:
Plato..
PLATO:
Yes Socrates?
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SOCRATES:
Can you tell me, are you human?
PLATO:
Why… yes, Socrates
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SOCRATES:
And would you agree, Plato, that a human knows what a chariot is?
PLATO:
Um, yep
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SOCRATES:
So you can tell me, then
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[Socrates produces a papyrus, showing a drawing of the corner of a chariot wheel]
SOCRATES:
*Is that a chariot*?
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PLATO:
Well
that’s more just a bit of wheel
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SOCRATES:
So not a *chariot*.
PLATO:
No.
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SOCRATES:
[Producing another papyrus with the full drawing of the chariot, chopped into boxes]
So if a man were challenged to “tap the boxes containing chariots to prove you’re human” when he was just trying to check his ClubCard points... *where could he tap*?
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PLATO:
Well you can’t tap any of them really
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SOCRATES:
So are we not human?
PLATO:
‘Spose not.
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[Bleak pause]
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PLATO:
I’ll get the hemlock
SOCRATES:
Yeah
[ends]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:4m3we4apbjayclzcnhwe3pfp/bafkreiazbuxbxnuyt5etli2cjseaychvbuym6n6z33nwx2mutlvoqjdhge)
