iiinova — where your digital self keeps evolving

Jürgen Zanghellini @juergenzanghellini.bsky.social · 05/09/2026

We all made it to the bottom — more or less safely 😅✅ #PROHITS #retreat

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 05/09/2026

Time to convert that potential energy into kinetic energy 🛒💨 #PROHITS #retreat

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 05/09/2026

For our next experiment @prohits.bsky.social climbed all the way up here just to increase our potential energy 🧪⛰️ #PROHITS #retreat

#PROHITS crowd on top of Mönichkirchner Schwaig

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 02/09/2026

Usually we model complex systems. Yesterday, two very different ones hit back: * wakeboarding on the Danube 💦 * singing karaoke w/ an impressive signal-to-noise ratio 🎤😄 A fun day with a fantastic team Thanks, everyone! ❤️ @univie.ac.at @prohits.bsky.social #circularbioengineering #FunMuseSens

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 10/08/2026

Continuous fermentation cascades are powerful production systems, yet tricky to design Enter ContiDesigner 🧪💻 chemnettools.anc.univie.ac.at/ContiDesigner Work led by Andrea C Graf at the Cluster of Excellence #CircularBioengineering, @univie.ac.at #Continuous #Bioprocessing #Biomanufacturing

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 03/07/2026

💊 Drug effects don’t happen in a cellular “bucket,” but in specific subcellular compartments Our new tool, #RegulomeXplorer, enables you to explore treatment effects on cytoplasmic and nuclear proteomes — interactively and visually 🧬 Try it out chemnettools.anc.univie.ac.at/RegulomeExpl...

Graphical abstract of RegulomeXplorer available at https://chemnettools.anc.univie.ac.at/RegulomeExplorer/

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 01/07/2026

Climate-related displacement at @univie.ac.at: the brave three of us who made it to uni today have migrated to our only air-conditioned room — the social room. ❄️ On the upside, we are now dangerously close to the coffee machine ☕

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 25/06/2026

What does a tent ⛺ have to do with microbial communities? A lot, actually! It describes the microbial playground. Its corners reveal ways they can interact: from specialization to commensalism to mutualism Check out how geometry reveals rules for microbial interactions doi.org/10.1098/rsif...

Feasible space of a (toy) microbial community. Figure taken from https://doi.org/10.1098/rsif.2025.0869

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 20/05/2026

Fantastic exchange between @w-u-r.bsky.social and @univie.ac.at on microbiology, systems biology, modelling, synthetic biology, and biotechnology 🧪 Great discussions & a visit to the Mass Spectrometry Centre reminded us that science is better face-to-face 😄 Thanks to everyone--you made it a blast!

PhD candidates from MIB and SSB groups at Wageningen University & Research, TU Wien and DoSChem at University of Vienna

Tour of the Mass Spectrometry Centre at UniVie

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 08/05/2026

Really great talk by #HannesLink at @univie.ac.at Wild to see genome-scale CRISPRi uncover just how tightly E. coli controls metabolite levels to keep metabolism efficient, robust

Hannes Link giving his lecture at @univie

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 03/12/2025

"We are very pleased to inform you that the project you submitted has been selected by the jury for funding" Stay tuned! 👀✨ @univie.ac.at @akbild.bsky.social #icom.austria

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 26/09/2025

💻 Keyboard warriors by day, 🎤 karaoke stars by night ✨ Yesterday’s team outing hit all the right notes 🎶 — well, most of them 🤣 @univie.ac.at @ds-vienna.bsky.social @prohits.bsky.social

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 06/08/2025

Some days the weight of it all just feels impossible to carry 😉 #Chocolate at @zotterchocolates.bsky.social

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 31/07/2025

40% of people have increased abundance of Methanobrevibacter in their gut In her stellar #MPA2025 keynote, @chmoei.bsky.social calls them “human cows”. They are typically slim and smart 😔 Sad to realize I’m not a human cow @univie.ac.at

Christine Moissl-Eichinger talking about “Archaeal-bacterial metabolic interactions in the human microbiome” at #MPA2025 in Vienna

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 30/07/2025

🚀 Brilliant talk by @flamholz.bsky.social at #MPA2025! Avi presented a unified model linking redox chemistry and cellular resource allocation Elegant, insightful, and predictive, just awesome 👏🧬🔥

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 30/07/2025

🎬 Straight from the red carpet to the green screen 🎥 The Glorious Four, @diana-sz.bsky.social #EladNoor #FelipeScott #MarceloRivas close out our summer school saga in style 🎞️ Fall release coming to a thread near you, don’t miss it @economic-cell.bsky.social @univie.ac.at @cecamevents.bsky.social

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 29/07/2025

@nicoc-micsynmet.bsky.social ramps up synthetic C1 metabolism, pushing C1 biotech from the lab close to the launchpad at #MPA2025 @univie.ac.at

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 25/07/2025

The cast keeps growing faster than E. coli in rich medium #SteffenWaldherr’s in, slate’s up, the signal is strong: Hasta la vista, baby. 🎥 @economic-cell.bsky.social @univie.ac.at 📚🌱

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 25/07/2025

🎬 Hollywood called, but @meikewortel.bsky.social said: “I’m booked – starring in Economic Principles in Cell Biology: The Sequel.” Catch her and the rest of the cast at the @univie.ac.at summer school 👉 @economic-cell.bsky.social 🎥🌱📚

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 24/07/2025

🎥 @pranasag.bsky.social understood the assignment: “Put your head in the game.” 🎬 The @univie.ac.at summer school Economic Principles in Cell Biology is in full swing! Catch us before we all lose our heads 👉 @economic-cell.bsky.social 🌱📚 supported by @cecamevents.bsky.social

@pranasag.bsky.social sticks his head through a film slate

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 23/07/2025

📸 #MarkusKöbis. Green screen. Slate snap. Filming is underway for "Economic Principles in Cell Biology" at our summer school @univie.ac.at 🌱📚 Check us out at @economic-cell.bsky.social before #Netflix grabs exclusive rights 🎬 Supported by @cecamevents.bsky.social

Markus Köbis in front of a green screen, snapping a slate before he records his video on Economic Principle in Cell Biology

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 19/05/2025

Time to suit up! Leopold Zehetner just nailed his PhD defense—modeling AAV production in HEK cells. Sharp style, even sharper science. Stellar work and a well-earned PhD Super proud and congratulations! @univie.ac.at Here is his key work doi.org/10.1016/j.ym...

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 09/05/2025

🚀 Liftoff from the #UniversePavilion at #Biennale2025 in Venice! Join Chief Bioengineer Mira Kordan and her team as they boldly go where no one has gone before! #acibGmbH @bokuvienna.bsky.social @tuwien.at @univie.ac.at www.universepavilion.com/portfolio/th...

Curator Claudia Schnugg, artist Kristina Pulejkova, and her scientific collaborators in front of the artwork "The Metabolic Guide to Space Survival."

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 08/05/2025

The Metabolic Guide to Space Survival check it out www.universepavilion.com/portfolio/th...

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 01/05/2025

🚨 Last call! #MPA2025 @univie.ac.at Abstract submission for the Metabolic Pathway Analysis Conference closes today! Don’t miss your chance to join a stellar lineup, including invited speakers @chmoei.bsky.social & @flamholz.bsky.social Submit now 👉 univie.eventsair.com/Presentation...

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 17/04/2025

Why do some HEK293 cells crank out more viral vectors than others? 🧬 We used multi-omics + metabolic modeling to find out. Turns out, pseudohypoxia is a big deal. Check out our new paper led by the fantastic #LeopoldZehetner & @diana-sz.bsky.social 🔗 doi.org/10.1016/j.ym... 🧵👇

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 06/04/2025

Do I put the cream before or after the ham in my #carbonara? Asking for my Italian nana. Happy #CarbonaraDay!

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 30/03/2025

Final boarding call for your future in bioengineering🚀 Takeoff tomorrow Mar 31, 23:59—last chance to apply for our PhD positions 🎯Computational Design of Optimal Bioprocesses 🔬Optimal Compartmentalization of Metabolic Pathways Hop on before it’s too late www.circularbioengineering.at/jobsprogram2

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 17/02/2025

Pro tip: When clapping the slate, KEEP YOUR FINGER OUT!!! 🎬 We're back for the 2nd shoot of our educational videos on Economic Principles in Cell Biology 🌱📚 Join us this July for lectures & interactive learning 📢 Register epcp.univie.ac.at/summer-school/ @economic-cell.bsky.social @univie.ac.at

Me, clapping the slate—with my finger in it

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 28/01/2025

🎥 Behind the scenes with @diana-sz.bsky.social shooting for the Economic Principles in Cell Biology summer school 🌱📚 Join us this July for cutting-edge lectures & interactive blended learning! 📢 Register epcp.univie.ac.at/summer-schoo... @economic-cell.bsky.social

@diana-sz.bsky.social is preparing to record her lecture

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 24/01/2025

Make the change happen—join us at the @fwf-at.bsky.social Centre of Excellence #CircularBioengineering 🌟 We’re hiring a Senior Administrator to lead management & coordination at the Centre 🌱 shape sustainable futures with groundbreaking research 🗓️ Apply by Feb 14 www.circularbioengineering.at/jobs

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 17/12/2024

Back in my PhD days he was already a star while my brain trust & I were just starlets finding our ways Today we reunited as Ferenc delivered a brilliant lecture on Molekulare Herzschläge für die Zukunft der Medizin Noble then—leading the way now Ferenc Krausz #ChristmasLecture @oeaw.bsky.social

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 11/12/2024

Is this my breakthrough? Am I headed to Hollywood? Thrilled to be interviewed by the Austrian Broadcasting Corporation about our #sciart project “The Metabolic Guide to Space Survival” Stay tuned! #science at @univie.ac.at @ds-vienna.bsky.social

Interviewing the artist: Kristina Pulejkova

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 19/11/2024

🎤 Excited to speak at the "Workshop Metabolism and Mathematical Models: Two for a Tango" 🧬 Sharing our insights on optimally designing biotechnological production processes with constraint-based process modeling ⏳ Starting in 5 minutes—join @ team.inria.fr/erable/en/ev... #Modeling #Biotechnology

Program "Workshop Metabolism and mathematical models: Two for a tango – 4th Edition"

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 13/11/2024

+104% in 2,3-butanediol productivity Check out #MathiasGotsmy's latest paper 📝 on designing competitive, green bioprocesses for 2,3-butanediol production ⚗️ 🔗 doi.org/10.1016/j.cs... Curious for more? Swing by Poster #48 at #ESIB!

Mathias Gotsmy presenting "Precision Modeling for 2,3-Butanediol Bioprocess Optimization" at the European Summit of Industrial Biotechnology 2024 in Graz, Austria

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 05/04/2024

🧙‍♂️ Ready to optimize bioprocesses with your data wizardry? We're seeking passionate data enthusiasts to join us in Vienna! Your mission: Pioneer #AI-enhanced models for smarter bioprocess design Get in touch and apply by April 14 shorturl.at/eCHR4 #PhD #jobs @ds-vienna.bsky.social @univie.ac.at

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 01/04/2024

🧬Easily & effortlessly generate communities of genome-scale metabolic models with PyCoMo for #COBRA ‼️Plus: Fully compliant w #SBML standards‼️ Check out doi.org/10.1093/bioi... Excellent collaboration lead by #MichaelPredl & #MarianneMiesskes w #CUBE @univie.ac.at ⚙️

Summary of PyCoMo
(A) Automated steps in creating compartmentalized community metabolic models. Final model components traceable to their origin. Models can be saved in SBML format with original flux bounds for reuse. Mass and charge balance checked, including external metabolites. Model structure adjustable for growth or abundance
(B) Feasible compositions at different growth rates in a three-species biogas community: Desulfovibrio vulgaris (DV), Methanospirillum hungatei (MH), Methanosarcina barkeri (MH). Medium contains ethanol and CO2; ethanol is Desulfovibrio vulgaris' substrate, producing substrates for other members
(C) Visualization of community metabolic model and cross-feeding interactions using ScyNet. Arrow colors denote feasible metabolite production (orange), uptake (green), or both (violet) by community members

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 18/02/2024

Plus, explore our accompanying blog post Cellular Architecture: the Secret to Cheap #Ribosomes communities.springernature.com/posts/cellul...

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 18/02/2024

Has evolution fine-tuned ribosomes for speed? If so, why are ribosomes—unlike most other enzymes—a blend of proteins and RNA? Explore the costs of ribosome biosynthesis in our latest paper spearheaded by the outstanding #DianaSzéliová from @univie.ac.at rdcu.be/dySdc

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 10/02/2024

Great pleasure to meet so many brilliant minds at OLISSIPO winter school 2024 – Fostering Computational Biology Research x.com/olissipo_eu/...

Group picture OLISSIPO winter school 2024

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 29/01/2024

Still a bit too early but looking very much forward to Anne L’Huillier’s presentation #NobelPrize #AttosecondPhysics

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 27/01/2024

Join PROHITS—a European MSCA Doctoral Network Explore & extend boundaries of experimental & computational approaches in resolving prokaryotic proteomes at single-cell level across temperatures 10 fully funded fellowships available—apply now prohits.eu/recruitment #jobs #PhD

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 26/01/2024

Thrilled to congratulate #MathiasGotsmy on a stellar defense! 🥳 Grateful for the opportunity to have guided you through the start of your academic journey, proud to witness your achievements & excited for a bright future ahead Huge congrats! 🙌 #phdlife #proudPI @univie.ac.at

Mathias Gotsmy after a successful PhD defense

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 15/12/2023

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Jürgen Zanghellini @juergenzanghellini.bsky.social · 13/11/2023

If Christmas comes early, the lab is prepared!

Gumtree decorated with Christmas chocolate in our lab

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