The cell-free biogenesis of the protein translation machinery is essential for the creation of a self-regenerating synthetic cell. Here the authors synthesise all 30 E. coli translation proteins in a ...

Nature Communications - Chromosomes are long DNA polymers, compacted in cells and fragile once released from the host. Here, authors report on a method to gently transplant bacterial chromosomes...

Nature Nanotechnology, Published online: 10 December 2025; doi:10.1038/s41565-025-02058-0A microfluidic-free platform of miniaturized compartments displays on-chip-synthesized antigen gradients for quantitative epitope mapping of monoclonal antibodies and profiling of human sera and of human receptor–viral antigen interactions.

Broad discussion is needed to chart a path forward

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Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible antivenom treatments.

A signal amplification circuit based on recycling nucleic acid inputs with RNA polymerase off-target transcription improves the sensitivity of transcription factor-based cell-free biosensors, achievin...

Nature Genetics - This genomic analysis of tandem kinase proteins across 104 plant species highlights their mechanisms of convergent molecular evolution and potential roles in plant immunity.

Biohybrid devices based on engineered cells interfaced with bioelectronics combine the strengths of each field, resulting in constructs with properties that are not otherwise achievable. In this Revie...

Engineering Turing patterns has been one of the most challenging problems in synthetic biology because even tiny changes in the reaction parameters destroy patterning. Here, the authors construct a more robust three-node genetic circuit in E. coli to generate different kinds of reproducible spot and stripe patterns.

Single-molecule fluorescence microscopy experiments with a recombinant Escherichia coli transcription–translation system provides insights into the coordination of the transcription and translation ma...

In this essay, I will put forth what I see as a major conceptual challenge for biology in the next decade, one that is inspired by Crick’s Central Dogma: understanding information flow in the cell in ...

Large-scale-integration of artificial cells on a chip can reveal emergent multicellular phenomena. Here, authors report 2D coupled lattices of artificial cells programmed by genetic oscillators, exhib...