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Jonathan Bohlen

@jonathanbohlen.bsky.social
380 followers 501 following 98 posts

Group leader at the Gene Center in Munich. RNA biology and protein translation in Immunity. Looking for excited and motivated students! Dad in Science, He/His Bohlenlab.com

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Reposted by Jonathan Bohlen
LMU München @lmu.de · 01/10/2026
🎉 Congratulations to @jonathanbohlen.bsky.social on receiving the Life Sciences Bridge Award from the @avefoundation.bsky.social! The #LMU molecular biologist is being recognized for his research into the molecular mechanisms underlying rare inherited immunodeficiencies. #LMUMunich
lmu.de
Prestigious early-career award for LMU molecular biologist Jonathan Bohlen
LMU molecular biologist Dr. Jonathan Bohlen has received the Life Sciences Bridge Award from the Aventis Foundation.
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Reposted by Jonathan Bohlen
Gene Center Munich @LMU Munich @genecenter-lmu.bsky.social · 28/09/2026
Amazing🤩 Congratulations, Jonathan!✨🚀 Prestigious early-career award for LMU molecular biologist Jonathan Bohlen www.lmu.de/en/newsroom/... @jonathanbohlen.bsky.social
lmu.de
Prestigious early-career award for LMU molecular biologist Jonathan Bohlen
LMU molecular biologist Dr. Jonathan Bohlen has received the Life Sciences Bridge Award from the Aventis Foundation.
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Jonathan Bohlen @jonathanbohlen.bsky.social · 28/09/2026
Thank you!!
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Jonathan Bohlen @jonathanbohlen.bsky.social · 28/09/2026
Vielen Dank an die Aventis Foundation für den Life Sciences Bridge Award 2026! 🏆
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Reposted by Jonathan Bohlen
Karousis Lab @karousislab.bsky.social · 24/09/2026
We report a human cell-free translation screen that identified NT-2, a Fusarium mycotoxin that blocks human ribosomes. The surprise: NT-2 does binds the ribosome and pushes them into a dormant state. www.nature.com/articles/s42...
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Jonathan Bohlen @jonathanbohlen.bsky.social · 11/09/2026
Oh no, what a loss. Very sorry to read this.
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Reposted by Jonathan Bohlen
Casanova Lab @casanovalab.bsky.social · 04/09/2026
1/ Delighted to share our paper in @jem.org today, led by Iris Fagniez and @ryangrui.bsky.social, two trainees just starting exciting new chapters in their careers: MD-PhD training at @harvardmed.bsky.social, @mit.edu, and Assistant Prof at @bcmhouston.bsky.social rupress.org/jem/article/...
rupress.org
Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity
Fagniez et al. identify new patients with inherited RORγT deficiency characterized by impaired TCRα rearrangement, depletion of MAIT and iNKT cells, reduce
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Jonathan Bohlen @jonathanbohlen.bsky.social · 31/08/2026
So the 5S array is a real, functional source of human genetic variation, shaped by the p53 pathway it controls. Explore it in our interactive atlas 👉 genesintranslation.com Preprint 👉 doi.org/10.64898/202... Experimental work by our master's student Laura Sengl, with the whole team. 🙌 4/4
genesintranslation.com
Genes in Translation
Atlases of genetic variation and function across the genes that build the translation machinery.
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Jonathan Bohlen @jonathanbohlen.bsky.social · 31/08/2026
We mutated every position of the gene. Variants that block assembly into the ribosome map to the uL18/uL5 interface and activate p53. These are exactly the variants that selection has purged from human populations. 3/4
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Jonathan Bohlen @jonathanbohlen.bsky.social · 31/08/2026
Every person carries variant 5S copies, and ~10% of people express variant 5S rRNA. 2/4
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Jonathan Bohlen @jonathanbohlen.bsky.social · 31/08/2026
🧬 New preprint: "Selection and surveillance of 5S ribosomal RNA genes in human populations." The 5S rRNA genes sit in a ~80-copy array on chromosome 1, one of the least-explored parts of the genome. We traced its variation from DNA to ribosome. 1/4🧵
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Reposted by Jonathan Bohlen
Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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Jonathan Bohlen @jonathanbohlen.bsky.social · 07/08/2026
Excited to share that I’ll be presenting my work at #ESID2026 in Maastricht! 🇳🇱 You can join the conversation too. Submit your late-breaking research by 30 August & get published in JHI! 🧬 👉 invt.io/1bxbz93skkb #ESID2026 #InbornErrorsOfImmunity #Immunology #IEI
invt.io
I will present my research at ESID 2026, join me
Register today and save!
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Jonathan Bohlen @jonathanbohlen.bsky.social · 12/07/2026
Very interesting paper on defect in RNA editing: rupress.org/jem/article-...
rupress.org
ADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype
In this work, we identify a new type I IFN–dependent psoriasis subtype resulting from rare heterozygous variants in ADAR1 and associated with a specific re
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Jonathan Bohlen @jonathanbohlen.bsky.social · 11/07/2026
Happy to see this story out! Congrats to Diana and everyone involved :)
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Reposted by Jonathan Bohlen
Casanova Lab @casanovalab.bsky.social · 11/06/2026
THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS: Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine www.nejm.org/doi/10.1056/...
nejm.org
Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM
Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...
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Jonathan Bohlen @jonathanbohlen.bsky.social · 06/06/2026
Similar think happened at JOCI. The community has founded JHI in response, and looks like we gained a spectarcular society journal as a result of springers greed. retractionwatch.com/2025/02/06/e...
retractionwatch.com
Editors resign from Springer immunology journal to launch nonprofit title
Several top editors of the Journal of Clinical Immunology, a Springer Nature title, have jumped ship to start a new, nonprofit journal with Rockefeller University Press.  Jean-Laurent Casanova…
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Jonathan Bohlen @jonathanbohlen.bsky.social · 29/05/2026
Wow! That's very bad! Great investigative work. @reeserichardson.bsky.social reeserichardson.blog/2026/05/28/h...
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
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Jonathan Bohlen @jonathanbohlen.bsky.social · 11/05/2026
Wow, cool! Adult onset autoimmunity can be genetic.
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Jonathan Bohlen @jonathanbohlen.bsky.social · 24/03/2026
Amazing work, contextualizing the mechanism of action of the widely used chemotherapeutic azacytidine. We are very happy to have contributed a little bit to this manuscript! Big congrats to Julian, Carla and everyone involved!
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Jonathan Bohlen @jonathanbohlen.bsky.social · 10/03/2026
I am excited to receive this fellowship, which will help us with our research on regulated mRNA translation in the human immune system! www.daimler-benz-stiftung.de/cms/de/foerd...
daimler-benz-stiftung.de
Daimler und Benz Stiftung – Stipendiaten 2026
Die Daimler und Benz Stiftung gibt Impulse – heute für Morgen. Über Ländergrenzen hinweg fördert sie interdisziplinäre Forschungsprojekte.
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Jonathan Bohlen @jonathanbohlen.bsky.social · 04/03/2026
I am very excited to share that our paper is on the cover of this month's JHI! rupress.org/jhi/issue/2/2
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Jonathan Bohlen @jonathanbohlen.bsky.social · 26/02/2026
There seems to be a problem with incentives for replication here. If the replicators cant replicate the data, the paper wont get published and neither will their work on replicating it. They shoot themselves in the leg. And that is ignoring the problem that NOONE will agree to try to replicate.
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Reposted by Jonathan Bohlen
Casanova Lab @casanovalab.bsky.social · 24/02/2026
This is the first News & Views of @jhumimmunity.org and it is a must-read ! TLR7 mutations leading to enhanced TLR7 signaling in humans url: rupress.org/jhi/article/...
rupress.org
TLR7 mutations leading to enhanced TLR7 signaling in humans
Three studies in this issue of JHI extend our understanding of the genetic, molecular, and clinical characteristics of human disease associated with a gain
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Jonathan Bohlen @jonathanbohlen.bsky.social · 19/02/2026
They're just really trying to milk the whole publishing landscape dry... Scientists need to stop feeding this machine. The OA initiative is nice, but not if 80-90% of the public money goes into companies with >50% profit margins... All this could go through university presses and societies.
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Jonathan Bohlen @jonathanbohlen.bsky.social · 16/02/2026
Very nice! Congrats to all involved!
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Jonathan Bohlen @jonathanbohlen.bsky.social · 13/02/2026
😅
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Jonathan Bohlen @jonathanbohlen.bsky.social · 13/02/2026
What did the central dogma do to you? 🫠
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Jonathan Bohlen @jonathanbohlen.bsky.social · 09/02/2026
Super cool! thank you
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Reposted by Jonathan Bohlen
Journal of Human Immunity @jhumimmunity.org · 06/02/2026
Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease. New study by Qinhua Zhou (Fudan University), Jacinta Bustamante @institutimagine.bsky.social, Jonathan Bohlen @jonathanbohlen.bsky.social @lmumuenchen.bsky.social & colleagues rupress.org/jhi/article/...
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Jonathan Bohlen @jonathanbohlen.bsky.social · 01/02/2026
Ruthless...
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Jonathan Bohlen @jonathanbohlen.bsky.social · 30/01/2026
JHI @jhumimmunity.org is the journal of the primary immunodeficiency societies worldwide, hosted by Rockefeller University Press. Open access: doi.org/10.70962/jhi... With Qinhua Zhou, Jacinta Bustamante, Jean-Laurent @casanovalab.bsky.social , and colleagues from six countries.
doi.org
Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease
X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Four new patients carried three previously undescribed truncating or loss-of-expr
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Jonathan Bohlen @jonathanbohlen.bsky.social · 30/01/2026
Building on our 2023 paper, we identified three new MCTS1 variants, including the first hypomorphic variant (p.W175*). Even partial loss of MCTS1 translation reinitiation activity can cause susceptibility to mycobacteria.
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Jonathan Bohlen @jonathanbohlen.bsky.social · 30/01/2026
New paper in the Journal of Human Immunity! We report complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease -- four new families from Iran, Oman, China, and the USA. doi.org/10.70962/jhi...
doi.org
Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease
X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Four new patients carried three previously undescribed truncating or loss-of-expr
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Reposted by Jonathan Bohlen
Rockefeller University Press @rupress.org · 30/01/2026
X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. In @jhumimmunity.org, Zhou et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...
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Reposted by Jonathan Bohlen
Journal of Human Immunity @jhumimmunity.org · 30/01/2026
X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Zhou, Bustamante, Bohlen et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...
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Jonathan Bohlen @jonathanbohlen.bsky.social · 30/01/2026
Not yet, but I would love to!!
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Jonathan Bohlen @jonathanbohlen.bsky.social · 29/01/2026
Our lab website is live! 🥳 We study how mRNA translation controls immune cell function and how defects in the protein synthesis machinery cause human disease. Come say hello and learn about what we do at the Gene Center Munich. bohlenlab.com
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Reposted by Jonathan Bohlen
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 27/01/2026
Active transport of tRNAs facilitates distributed protein synthesis www.biorxiv.org/content/10.64898/20…
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Jonathan Bohlen @jonathanbohlen.bsky.social · 25/01/2026
Support dogs guide blind people all day long but never become blind? What can we learn?
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Reposted by Jonathan Bohlen
LMU München @lmu.de · 23/01/2026
🙌 Herzlichen Glückwunsch! @jonathanbohlen.bsky.social und Jiamin Hou wurden von der @dfg.de im Rahmen des Emmy Noether-Programms ausgezeichnet. Die Fördersumme beträgt jeweils 1,85 Mio. Euro für einen Zeitraum von sechs Jahren. #LMUMuenchen #Astrophysik #Molekularbiologie www.lmu.de/de/newsroom/...
lmu.de
Emmy Noether-Förderung für zwei LMU-Forschende
Astrophysikerin Jiamin Hou und Molekularbiologe Jonathan Bohlen erhalten Förderungen aus dem Emmy Noether-Programm der DFG.
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Jonathan Bohlen @jonathanbohlen.bsky.social · 21/01/2026
I don't want to be a huge stickler and I actually really like this paper, congrats to the authors for the nice work. But isn't the use of human eyes in the graphical abstract rather misleading for a paper that contains entirely mouse experiments?
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Jonathan Bohlen @jonathanbohlen.bsky.social · 18/01/2026
Awesome, thanks for the enthusiasm!!
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Jonathan Bohlen @jonathanbohlen.bsky.social · 16/01/2026
Finally, I do think it is really worth understanding what you're doing when analyzing such data, otherwise what you get out might not be very useful! So a bioinfo course could be a great idea! Good luck!
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Jonathan Bohlen @jonathanbohlen.bsky.social · 16/01/2026
Is this question just abou data analysis or also about producing a new dataset in an experiment? Most published datasets have already count matrices submitted to repositories such as NCBI Geo or similar, maybe you wont need to do the analysis. Otherwise usegalaxy.org is the easiest solution I know.
usegalaxy.org
Galaxy
Galaxy is a community-driven web-based analysis platform for life science research.
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Jonathan Bohlen @jonathanbohlen.bsky.social · 15/01/2026
Thank you Kilian!!
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Jonathan Bohlen @jonathanbohlen.bsky.social · 15/01/2026
Thank you!!!
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Jonathan Bohlen @jonathanbohlen.bsky.social · 15/01/2026
Huge thanks also to all the amazing collaborators and colleagues all around the world, who made this happen. Finally, many, many thanks to the patients and their families for supporting and enabling our research. fin/n
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Jonathan Bohlen @jonathanbohlen.bsky.social · 15/01/2026
Huge thanks and congrats go to exceptional first authors Taja Vatovec (in my lab) and my friend Anna-Lena Neehus @alneehus.bsky.social in Boston! Furthermore, many thanks to @casanovalab.bsky.social for letting me start this project in Paris. 5/n
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Jonathan Bohlen @jonathanbohlen.bsky.social · 15/01/2026
We also found striking defects in B cell function in vivo, by studying the response to SARS.CoV2 mRNA vaccination in a subset of patients. For many more interesting obsevations and experiments, please read the paper! 4/n
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