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Jonathan Bohlen

@jonathanbohlen.bsky.social

380 followers 501 following 98 posts

Group leader at the Gene Center in Munich. RNA biology and protein translation in Immunity. Looking for excited and motivated students! Dad in Science, He/His Bohlenlab.com

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Jonathan Bohlen @jonathanbohlen.bsky.social · 31/08/2026

We mutated every position of the gene. Variants that block assembly into the ribosome map to the uL18/uL5 interface and activate p53. These are exactly the variants that selection has purged from human populations. 3/4

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Jonathan Bohlen @jonathanbohlen.bsky.social · 31/08/2026

Every person carries variant 5S copies, and ~10% of people express variant 5S rRNA. 2/4

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Jonathan Bohlen @jonathanbohlen.bsky.social · 31/08/2026

🧬 New preprint: "Selection and surveillance of 5S ribosomal RNA genes in human populations." The 5S rRNA genes sit in a ~80-copy array on chromosome 1, one of the least-explored parts of the genome. We traced its variation from DNA to ribosome. 1/4🧵

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Jonathan Bohlen @jonathanbohlen.bsky.social · 04/03/2026

I am very excited to share that our paper is on the cover of this month's JHI! rupress.org/jhi/issue/2/2

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Jonathan Bohlen @jonathanbohlen.bsky.social · 15/01/2026

We also found striking defects in B cell function in vivo, by studying the response to SARS.CoV2 mRNA vaccination in a subset of patients. For many more interesting obsevations and experiments, please read the paper! 4/n

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Jonathan Bohlen @jonathanbohlen.bsky.social · 15/01/2026

CBL deficient mice have defects in T cell development and function. Yet, surprisingly, the CBL deficient T cells of the patients were largely unaffected. Conversely, B cell development was strongly perturbed. 3/n

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Jonathan Bohlen @jonathanbohlen.bsky.social · 15/01/2026

We studied patients with somatic CBL deficiency. These patients often have transient myeloproliferation in childhood, and as we published recently (www.jci.org/articles/vie...) chronic autoinflammation. We noticed that our cohort of CBL deficient patients had a high rate of severe infections. 2/n

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Jonathan Bohlen @jonathanbohlen.bsky.social · 13/11/2024

I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinical-invest.bsky.social If you’re interested in the causes of autoinflammation, then this one is for you: t.co/uhVDdzqyx2

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