Aging disrupts microglial function, but factors that rejuvenate these cells are poorly characterized. Here, the authors show the youth-associated protein TIMP2 revitalizes microglia by altering inflam...

There is little understanding of how aging serves as the strongest risk factor for several neurogenerative diseases. Specific neural cell types, such as microglia, undergo age-related maladaptive chan...

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Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...

Molecular Psychiatry - Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity