iiinova — where your digital self keeps evolving

Reposted by Jessica Rosarda

Alejandra Mendoza @thepenkpanther.bsky.social · 01/04/2026

Excited to share that our lab’s first preprint is now available! This work reflects a huge effort from graduate student Abeera Mehmood and coauthors! If you are interested in what B cells make all antibodies against norovirus take a look! www.biorxiv.org/content/10.6...

biorxiv.org

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Jessica Rosarda @jessica-rosarda.bsky.social · 13/02/2026

Congratulations to Prasanna Satpute-Krishnan (@pskcellbio.bsky.social) for winning the USU Henry C. Wu Award for Excellence in Basic Science Research!

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Reposted by Jessica Rosarda

Science Magazine @science.org · 09/01/2026

Scientists have identified a protein that acts as a brake on the breakdown of lipids in the liver that’s regulated by both feeding and the circadian rhythm, according to new #ScienceSignaling research involving mice. scim.ag/4bkWSKf

scim.ag

The ubiquitin E3 ligase HRD1 restricts hepatic lipid metabolism by suppressing PPARα-driven m6A RNA modification

m6A modification of mRNAs promotes hepatic lipid metabolism and is blocked by HRD1-mediated ubiquitination.

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Reposted by Jessica Rosarda

Danielle Grotjahn @nanigrotjahn.bsky.social · 22/12/2025

JCB’s Cover of the Year voting is open! I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬 #teamtomo @attychang.bsky.social

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Reposted by Jessica Rosarda

Feyza Engin @enginlab.bsky.social · 26/11/2025

Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1. www.nature.com/articles/s41...

nature.com

Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications

Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...

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Reposted by Jessica Rosarda

PLOS Biology @plosbiology.org · 14/04/2025

TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5

During RESET, misfolded GPI-APs traffic from the ER to the Golgi. Top left : Time-lapse imaging sequence collected immediately after thapsigargin (TG) treatment of a typical YFP-PrP * NRK cell that was co-expressing ER-marker, Cerulean-calnexin (CER-CNX). Scale bar represents 10 µm. Top right: Plot of the average Pearson’s r values between YFP-PrP * and CER-CNX for 9 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG. Bottom left: Time-lapse imaging sequence collected immediately after TG-treatment of a typical YFP-PrP * NRK cell that was co-expressing the Golgi marker, CER-GalT. Scale bar represents 10 µm. Bottom right: Plot of the average Pearson’s r values between YFP-PrP * and CER-GalT for 10 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG.

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Reposted by Jessica Rosarda

Stephen Turner @stephenturner.us · 16/04/2025

Bioconductor 3.21 released with 72 new software packages, for a total of 2341 software packages, 432 experiment data packages, 928 annotation packages, 30 workflows and 5 books bioconductor.org/news/bioc_3_... 🧬🖥️🧪 #Rstats

bioconductor.org

Bioconductor - Bioconductor 3.21 Released

The Bioconductor project aims to develop and share open source software for precise and repeatable analysis of biological data. We foster an inclusive and collaborative community of developers and…

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Reposted by Jessica Rosarda

Science Magazine @science.org · 15/04/2025

Metabolic dysregulation is a driving force of aging. Enzymes from lower organisms—such as bacteria and yeast—may be able to reverse age-associated metabolic changes in humans, a new #ScienceAdvances study finds.

scim.ag

Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases

Using enzymes from lower organisms, which are not encoded in the mammalian genome, delays aging and age-related diseases.

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Reposted by Jessica Rosarda

Atty (Ya-Ting) Chang @attychang.bsky.social · 09/04/2025

Happy to share the first paper in my PhD is published in JCB! It's my honor to work with amazing teammates! I really enjoy exploring mitochondrial protein import mechanism through cryo-ET!

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