iiinova — where your digital self keeps evolving

Reposted by E. Taylor Stone

Jesse Erasmus @jesseerasmus.bsky.social · 06/05/2025

Collab btwn NIAID (Dr. Andrea Marzi’s lab) and HDT Bio just published! 🧪 Filovirus gold-standard VSV vax platform compared to LION/repRNA (each encoding same antigen seq) for ability to provide single-dose protection in guinea pigs against Sudan virus challenge 🧵(1/2) www.nature.com/articles/s41...

nature.com

Single-dose replicon RNA Sudan virus vaccine uniformly protects female guinea pigs from disease - Nature Communications

Sudan virus (SUDV) outbreaks in Uganda created public health concerns due to a lack of approved vaccines. In this study, the authors develop a repRNA SUDV vaccine and demonstrate full protection of a ...

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Reposted by E. Taylor Stone

Jesse Erasmus @jesseerasmus.bsky.social · 15/04/2025

Just published! Here we report immunogenicity and efficacy of our replicon RNA vaccine against Crimean-Congo hemorrhagic fever in a cynomolgus macaque model of #CCHFV infection. Stay tuned as we advance this candidate in clinical trials. www.thelancet.com/journals/ebi...

thelancet.com

A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques

Our data demonstrate that our repNP vaccine and NP-specific antibody can protect against CCHFV in non-human primates.

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Reposted by E. Taylor Stone

Jason McLellan @mclellanlab.bsky.social · 18/06/2025

Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

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Reposted by E. Taylor Stone

Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 31/01/2025

Looks like #Uganda will use #IAVI's #Ebola Sudan vaccine in a clinical trial aimed at helping to halt the country's outbreak. The trial could also provide evidence of the vaccine's efficacy. As I reported y'day, there are already doses in Uganda — 2160, in fact. www.who.int/news/item/31...

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E. Taylor Stone @etaylorstone.bsky.social · 15/01/2025

When you design a vaccine and by the time the paper comes out you’ve made three updated versions as the virus continues to evolve 😅 #influenza #RNAviruses

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