A self-amplifying RNA vaccine for enterovirus D68 elicits neutralizing antibodies in mice and nonhuman primates and protects mice from disease.

Erasmus and Archer et al. describe the optimization of monoclonal antibody expression from replicon RNA in order to enable efficacy following intramuscular delivery of formulated RNA. Using Zika virus...

Enterovirus D68 (EV-D68), a respiratory pathogen increasingly associated with acute flaccid myelitis (AFM),1,2,3 represents a growing unmet need for vaccination. Kunishima et al. report an mRNA vaccin...

Genetic muscle diseases are difficult to treat due to challenges in delivering gene editors to muscles throughout the body. Here, authors engineer muscle-specific virus-like particles that fuse with s...

LION-delivered replicating RNA vaccines are immunogenic and protect cynomolgus macaques against lethal influenza A (H5N1) virus challenge.

/PRNewswire/ -- HDT Bio Corporation, a U.S.-based clinical-stage biotechnology company advancing immune-enhancing solutions for global health, biodefense, and...

Lipid nanoparticles (LNPs) are a modular, non-viral nucleic acid delivery system. Here, Eygeris and colleagues report that addition of saponin molecules, such as quillaic acid, to LNP formulations can...

Sudan virus (SUDV) outbreaks in Uganda created public health concerns due to a lack of approved vaccines. In this study, the authors develop a repRNA SUDV vaccine and demonstrate full protection of a ...

Our data demonstrate that our repNP vaccine and NP-specific antibody can protect against CCHFV in non-human primates.

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

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