iiinova — where your digital self keeps evolving

Reposted by Jenny Nathans

allen institute @alleninstitute.org · 08/10/2026

Scientists at Seattle Hub for Synthetic Biology just built the largest cellular family tree ever for a mammal, tracing how a single egg divided into 1.28 million cells. bit.ly/4zqcRjh

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Sudarshan Pinglay @sudpinglay.bsky.social · 06/10/2026

Excited to share Shotgun Genetic Engineering, developed by @julietrolle.bsky.social out now @natbiotech.nature.com! Read on to learn how Julie enabled mammalian cells to grow without 2 essential amino acids for the first time in >500 million years using highly multiplexed metabolic engineering!

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Reposted by Jenny Nathans

Junhong Choi @choijunhong.bsky.social · 11/08/2026

Excited to share the first preprint from our lab! We combined a DNA Typewriter lineage recorder with clone-resolved founder profiling to find what makes metastatic potential heritable in lung cancer xenografts. 1/13 www.biorxiv.org/content/10.6...

biorxiv.org

Time-resolved lineage recording reveals a pre-existing, heritable cell state underlying metastatic potential

Metastasis causes most cancer deaths, yet no recurrent mutation specifically drives it, raising the possibility that metastatic potential is a non-genetic yet heritable cell state. Classic experiments...

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Beth Martin @bkmartin.bsky.social · 31/07/2026

This was so fun to be a part of! Just an amazing feat of collaboration with a bunch of brilliant scientists. ♥️ 🧬

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Reposted by Jenny Nathans

Jay Shendure @jshendure.bsky.social · 31/07/2026

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n

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Jay Shendure @jshendure.bsky.social · 30/07/2026

New preprint from Shendure Lab on Locus-Scale aka Long-@$$ MPRAs led by the amazing Abby McGee & @carinabiar.bsky.social Most MPRAs test ~300 bp fragments next to a promoter. But real enhancers are bigger, act combinatorially and from a distance. 1/n www.biorxiv.org/content/10.6...

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Jonas Koeppel @jonaskoeppel.bsky.social · 04/06/2026

1/n What fraction of the human genome is essential for cells? Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads. @sudpinglay.bsky.social @jshendure.bsky.social www.biorxiv.org/content/10.6...

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Reposted by Jenny Nathans

Nature @nature.com · 03/06/2026

A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch, says synthetic biologist Sudarshan Pinglay. go.nature.com/4uRxXVQ

go.nature.com

Why a synthetic human genome is still worth building

A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.

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Reposted by Jenny Nathans

Jay Shendure @jshendure.bsky.social · 10/04/2026

Latest from Shendure & Qiu labs (@cxqiu.bsky.social) )! We combined a new 4M cell mouse whole embryo scATAC-seq atlas (E10-P0), millions of 'evolutionarily coherent' orthologs from 241 mammalian genomes (Zoonomia), and the CREsted CNN framework (@steinaerts.bsky.social).

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Troy McDiarmid @troymcdiarmid.bsky.social · 02/04/2026

Stoked to announce that I’m starting a lab as an Assistant Professor in the School of Biomedical Engineering and Centre for Brain Health at UBC! mcdiarmid-lab.sbme.ubc.ca Recruiting at all levels - please share the word! Cheers and happy long weekend all!

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Reposted by Jenny Nathans

Caroline Kikawa @ckikawa.bsky.social · 22/02/2026

So honored to have received this award! Thank you to the Experiement Foundation and @navigation.org

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Reposted by Jenny Nathans

Troy McDiarmid @troymcdiarmid.bsky.social · 15/02/2026

Check out our new protocol paper on molecular recording of transcriptional events in genomic DNA! Super fun pulling this together with @jennynathans.bsky.social @chenomics.bsky.social and @jshendure.bsky.social

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Reposted by Jenny Nathans

Will Chen @chenomics.bsky.social · 13/02/2026

We have significantly improved the protocol for recording CRE activities and orders with ENGRAM. We also designed new plasmids for easier cloning. Great work with @jennynathans.bsky.social, @troymcdiarmid.bsky.social and @jshendure.bsky.social . Happy recording!!

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Jenny Nathans @jennynathans.bsky.social · 13/02/2026

Super happy to share our protocol for ENGRAM is out in Nature Protocols! This was fun to write with @chenomics.bsky.social @troymcdiarmid.bsky.social @jshendure.bsky.social. In it we describe how to record CRE identity, activity, and order in mammalian cells.

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Lea Starita @leastarita.bsky.social · 23/11/2025

The amazing @shawnfayer.bsky.social has developed a saturation genome editing method in iPSCs enabling MAVEs in differentiated cell types and diploid contexts. Please check it out! And, for some lucky department, Shawn is on the faculty job market!

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Reposted by Jenny Nathans

Troy McDiarmid @troymcdiarmid.bsky.social · 05/11/2025

Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies” shorturl.at/H3Qww This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon. Bluetorial below.

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Reposted by Jenny Nathans

cxqiu.bsky.social @cxqiu.bsky.social · 04/11/2025

Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/

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Reposted by Jenny Nathans

Jay Shendure @jshendure.bsky.social · 14/10/2025

Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here: www.biorxiv.org/content/10.1...

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Nobu Hamazaki @nobuhamazaki.bsky.social · 26/09/2025

New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...

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Steve Cappell @stevecappell.bsky.social · 30/07/2025

Check out our new paper by postdoc Debasish Paul, out now in @Nature.com. Cells need a boost of energy to jumpstart the cell cycle, but how can this happen while the APC/C is inhibiting glycolysis? We found cells solve this paradox through a highly dynamic mechanism. www.nature.com/articles/s41...

nature.com

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry - Nature

APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.

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