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Journal of Experimental Medicine @jem.org · 15h

Read Dr. Melero and colleagues’ JEM study: TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment. hubs.la/Q04wZjm20

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Journal of Experimental Medicine @jem.org · 15h

“We are very proud of our JEM article and feel that it will receive wide exposure in the community.” — Ignacio Melero, Universidad de Navarra @unav.edu. 👉 Learn more about submitting to a journal valued by the community for its impact and integrity. hubs.la/Q04wZhXq0

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Journal of Experimental Medicine @jem.org · 19h

Jiaojiao Zhang, Tian Zhao, Hong Lei, Rui Gan et al. identify the transcription factor GABPA as a critical regulator of STING expression, pivotal for antiviral defense and inflammatory diseases. rupress.org/jem/article/... #InnateImmunity #inflammation #Lupus #SLE

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Journal of Experimental Medicine @jem.org · 20h

Thornton, Shevach et al. demonstrate that in #Tregs, the transcription factor Helios directly controls Tcf1, Lef1, Id3, and Bach2 to regulate effector Treg generation and terminal differentiation. Mice with Helios-deficient Tregs show #adipose -specific #autoimmunity. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 30/09/2026

What’s a Journal-Based #CME activity? A full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME activity in collaboration with @mskcme.bsky.social is NOW available 👉 mskcc.cloud-cme.com/course/cours...

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Journal of Experimental Medicine @jem.org · 28/09/2026

📢 Tell your friends and colleagues about JEM’s Early Career Travel Award! ✈️ 🧳 We're providing support for #gradstudents and early-career #postdoc researchers to attend the #VIB #Neuroimmunology Conference @vibtrainconf.bsky.social in Antwerp! Apply here 👉 rupress.org/jem/pages/ea...

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Journal of Experimental Medicine @jem.org · 28/09/2026

Jensen, Skouboe, Gervais, Mogensen et al. report the finding of #autoantibodies neutralizing type I IFNs in the blood and/or cerebrospinal fluid in a significantly elevated fraction of adults with HSV encephalitis (5%) compared with the general population rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 25/09/2026

Yang Yu, Yanling Zhao, Zhongcheng Shi, Larry L. Wang, Chunchao Zhang, Jianhua Yang et al. demonstrate that CAMKV, previously classified as a nonfunctional pseudokinase, possesses intrinsic kinase activity driven by MYC/MYCN oncogenes to promote #neuroblastoma growth. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 25/09/2026

Insights: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic #TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. From Hee Yeun Won & Jung-Hyun Park: rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 25/09/2026

Tomás S. Huerta, Kevin J. Tracey, Isaac M. Chiu, and @changsbrain.bsky.social review the organization and function of vagal neuroimmune circuits, from afferent cytokine sensing to organ-specific efferent immune control. rupress.org/jem/article/... #BioelectronicMedicine #Neuroimmunology

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Journal of Experimental Medicine @jem.org · 25/09/2026

Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity. From Dovran Ovezgeldiyev, Vanessa Trefzer, Rory Doolan, Julia Esser-von Bieren, Nicola L. Harris, Tiffany Bouchery @boucheryt.bsky.social @monashuniversity.bsky.social et al. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 24/09/2026

Functional heterogeneity and plasticity in naïve #CD8 #Tcells drive superior effector and memory responses. New study from Yamato Sajiki, Koichi Araki @arakilab.bsky.social and colleagues @cincyresearch.bsky.social: rupress.org/jem/article/... #LymphocyteBiology #InfectiousDisease #HostDefense

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Journal of Experimental Medicine @jem.org · 23/09/2026

C3 and CD47 mediate sensory-motor circuit refinement during spinal cord development. New study from Danny Florez-Paz and George Z. Mentis @columbiauniversity.bsky.social: rupress.org/jem/article/... See the short video summary by Flores-Paz: youtu.be/rLIF0vft17w #Neuroscience

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Journal of Experimental Medicine @jem.org · 23/09/2026

✍️💻 Participate in a complimentary Journal-Based #CME activity that consists of a full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME Activity @mskcme.bsky.social is NOW available 👉 mskcc.cloud-cme.com/course/cours...

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Journal of Experimental Medicine @jem.org · 23/09/2026

UA-30 mitigates systemic #aging and motor decline by inhibiting RalA signaling in naturally aged mice. New study from Bingge Zhang, Ye He, Ruiming Zhang, Yongmei Xie, Gongping Liu, Xifei Yang (Huazhong University of Science and Technology) and colleagus: rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 21/09/2026

📢 We're now accepting applications for the JEM Early Career Travel Award, for grad students & early-career postdocs to participate in #VIB #Neuroimmunology Conference @vibtrainconf.bsky.social in Antwerp! Deadline ⏰ October 16, 2026 Apply here 👉 rupress.org/jem/pages/ea...

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Journal of Experimental Medicine @jem.org · 21/09/2026

🔬 From our September issue (rupress.org/jem/issue/22...): Image shows Kim 1 expression in the kidney of Cdh16 Lrp1 mice by IHC at day 7 post-infection. Choi et al. identify a downstream tPA–LRP1 axis that safeguards the renal epithelium during systemic #candidiasis. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 18/09/2026

Ovezgeldiyev, Trefzer, Doolan, @boucheryt.bsky.social et al. reveal a metabolic pathway linking lipid mediator production to #macrophage activation during #helminth immunity. rupress.org/jem/article/... #Metabolism #InnateImmunity #inflammation #InfectiousDisease #HostDefense

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Journal of Experimental Medicine @jem.org · 17/09/2026

Read Dr. Melero and colleagues’ JEM study: TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment. hubs.la/Q04wZjm20

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Journal of Experimental Medicine @jem.org · 17/09/2026

“JEM doubtlessly is among the most prestigious journals in the overall field of medicine and in particular for the fields of immunology and inflammation.” — Ignacio Melero @unav.edu Learn more about submitting to a journal valued by the community for its impact and integrity. hubs.la/Q04wZhXq0

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Journal of Experimental Medicine @jem.org · 17/09/2026

Upper respiratory tract #CD8⁺ tissue resident memory #Tcells protect against viral transmission. New study from Sarah E. Michalets, Jacob E. Kohlmeier and colleagues (Emory University): rupress.org/jem/article/... #InfectiousDisease #HostDefense #MucosalImmunology

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Journal of Experimental Medicine @jem.org · 16/09/2026

Florez-Paz & Mentis demonstrate the presence of supernumerary synapses during development, resulting in miswired immature spinal circuits. Two molecularly distinct mechanisms are responsible for their refinement, incl. a surprising CD47-dependent mechanism rupress.org/jem/article/... #Neuroscience

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Journal of Experimental Medicine @jem.org · 16/09/2026

Zhang et al. identify RalA-dependent signaling as a regulator of age-related #skeletalmuscle dysfunction. The novel compound UA-30 inhibits RalA activity, reduces muscle #fibrosis, improves mitochondrial function & mobility, & extends health span & survival in mice. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 16/09/2026

Vps4B controls caspase-1 dynamics at the ASC speck to drive #inflammasome activation. New study from Yanfeng Li, Qingqing Xie, Longjun Li, Xiaoqing Xu, Tao Xu, Xiaopeng Qi (Shandong University) and colleagues: rupress.org/jem/article/... #InfectiousDisease #HostDefense #InnateImmunity #inflammation

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Journal of Experimental Medicine @jem.org · 15/09/2026

New content is available in our journal-based #CME activities @mskcme.bsky.social: 📄 “Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine)” (Conde et al. doi.org/10.1084/jem....) Begin the activity 👉 mskcc.cloud-cme.com/course/cours...

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Journal of Experimental Medicine @jem.org · 15/09/2026

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment. New study from Elixabet Bolaños, Ignacio Melero @unav.edu and colleagues: rupress.org/jem/article/... #TumorImmunology

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Journal of Experimental Medicine @jem.org · 14/09/2026

Explore our #cancer #Immunotherapy collection showcasing a broad range of topics, including the therapeutic potential of targeting cDC1, a strategy to harness the immunosuppressive potential of inhibitory receptors, targeting of inhibitory receptor agonists, and more: 👉 rupress.org/jem/collecti...

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Journal of Experimental Medicine @jem.org · 11/09/2026

Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity. New study from Iris Fagniez, Jean-Laurent Casanova @casanovalab.bsky.social, Rui Yang @ryangrui.bsky.social @rockefeller.edu & colleagues: rupress.org/jem/article/... #Immunodeficiency

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Journal of Experimental Medicine @jem.org · 11/09/2026

The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T Cells. From Marco Ongaro, Grégory Verdeil and colleagues: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 10/09/2026

Michalets, Kohlmeier et al. demonstrate that upper respiratory tract tissue-resident memory #CD8⁺ T cells are sufficient to protect against respiratory virus transmission, even in the absence of #CD4 #Tcells, #Bcells, or lower respiratory tract immune responses. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 10/09/2026

JEM is pleased to present opportunities to engage in #CME @mskcme.bsky.social. The latest activity is now available 👉 mskcc.cloud-cme.com/course/cours... 📄 “Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine” (Conde et al. doi.org/10.1084/jem....)

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Journal of Experimental Medicine @jem.org · 10/09/2026

Intravesical mesothelin-based #CARTcells targeting MUC16 effectively control #BladderCancer in preclinical models. From Parwiz Abrahimi, Renier Brentjens, Jedd Wolchok, Taha Merghoub et al.: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 09/09/2026

New study by Li et al. identifies that the ATPase Vps4B controls caspase-1 dynamics at the ASC speck to promote #inflammasome activation. This self-rejuvenating mechanism of the ASC speck opens up new avenues for therapeutic intervention in inflammatory diseases. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 09/09/2026

Serotype skewing and immune imprinting shape response to the tetravalent #dengue virus #Qdenga #vaccine. From Luciana Conde, Valter Monteiro, Joao Freitas, Mauro Teixeira @ufmgbr.bsky.social, Carolina Lucas @carolilucas.bsky.social @yaleschoolofmed.bsky.social et al. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 09/09/2026

@ostendorflab.org, @immushuang.bsky.social, @sohailtavazoie.bsky.social et al. show that activation of LXRs elicits a T cell "pre-effector" state that enhances priming and promotes anti-tumor immunity. rupress.org/jem/article/... In #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 09/09/2026

CD1d remodels the tumor-infiltrating myeloid populations controlling anti-tumor immunity. From Lauren Evans, Maria Conde Poole, Patricia Barral @barrallab.bsky.social: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 08/09/2026

Bolaños, Melero et al. @unav.edu show that tumor necrosis factor sensing by cancer cells through TNFR1 sets in motion forms of immunosuppressive protumor #inflammation that mediate escape from immune surveillance against tumors. rupress.org/jem/article/... #TumorImmunology

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Journal of Experimental Medicine @jem.org · 08/09/2026

Targeting Mettl8-Tcf1 axis promotes CD8⁺ TPEX differentiation and antitumor immunity. From Jiaxi Song, Dan Cui, Qizhao Huang, Jia Li, Fengyin Li, and colleagues: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 08/09/2026

Tumor-reactive LAG3⁺CD8⁺ T cells diverge into terminally exhausted cells and long-lived memory T cells. From Vaishali Aggarwal, Yangxi Sun, Chang Liu, Dario Vignali @vignalilab.bsky.social: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 07/09/2026

Functional heterogeneity and plasticity in naïve #CD8 #Tcells drive superior effector and memory responses. New study from Yamato Sajiki, Koichi Araki and colleagues @cincyresearch.bsky.social: rupress.org/jem/article/... #LymphocyteBiology #InfectiousDisease #HostDefense

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Journal of Experimental Medicine @jem.org · 07/09/2026

Our September cover (rupress.org/jem/issue/22... ) depicts a confocal image of Ramos B cells extracting surface-bound antigen from plasma membrane sheets. Sheets are labeled w/ fluorescent surrogate antigen (magenta); B cells are marked by CD19 (orange). See Berzosa et al. doi.org/10.1084/jem....

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Journal of Experimental Medicine @jem.org · 07/09/2026

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity. From Shibo Liu, Guanghao Liang, Yayun Yang, Yanyang Shi, Lihui Dong, Peng R. Chen, Meng Michelle Xu et al.: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 07/09/2026

In this review, Almonte, Thomas, and Zitvogel highlight how the gut #microbiome modulates immune checkpoint blockade efficacy in #cancer. rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 06/09/2026

T cell engagers emerge as a compelling therapeutic modality. A review from Baeuerle, Grieshaber-Bouyer, Sauer, and Michaelson: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 05/09/2026

Advances in the development of personalized neoantigen therapies. Mirabile–Brightman and Butterfield discuss the status of cancer vaccination in this review: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 04/09/2026

Fagniez et al. identify new patients with inherited RORγT deficiency characterized by impaired TCRα rearrangement, depletion of MAIT and iNKT cells, reduced numbers of TH17, TH1*, and CD8+ T cells, and defective IFN-γ and IL-17 immunity against #Mycobacterium & #Candida. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 04/09/2026

PML-driven #sumoylation of PML::RARA-bound repressors drives hematopoietic progenitor immortalization. New study from Hsin Chieh Wu, Marie-Claude Geoffroy, Hugues de Thé @college-de-france.fr and colleagues: rupress.org/jem/article/... #Leukemia #HumanDiseaseGenetics

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Journal of Experimental Medicine @jem.org · 03/09/2026

Ward, Kar, Balan & @bhardwajlab.bsky.social review how conventional cDC1s coordinate antitumor immunity through cross-presentation, immune cell networking, and spatial organization in tumors. rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

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Journal of Experimental Medicine @jem.org · 03/09/2026

Are you headed to @cshasia.bsky.social meeting on #cancer #immunotherapy in Suzhou? Meet our Deputy Editor, Gaia Trincucci (@gaiajexpmed.bsky.social), to discuss your research in person! 👉 Email Gaia: rupress.org/jem/pages/ed... Read our new collection on the topic: 👉 rupress.org/jem/collecti...

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Journal of Experimental Medicine @jem.org · 03/09/2026

Explore JEM's new collection highlighting the latest discoveries in #cancer #immunology and #immunotherapy, timed to coincide with the @cshasia.bsky.social meeting on the topic in Suzhou, China. 👉 rupress.org/jem/collecti...

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