CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.

The brain’s ability to adapt and support learning relies on experience-dependent synaptic plasticity, where connections between neurons are strengthened or weakened in response to activity. Recent res...

Molecular Psychiatry - Hippocampal ensembles regulate circuit-induced relapse of extinguished fear

Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...

Neuropsychopharmacology - Posttraining noradrenergic stimulation maintains hippocampal engram reactivation and episodic-like specificity of remote memory

Long-term fear memory storage involves gradual reorganization of supporting brain regions over time, a process termed systems consolidation. Memories initially rely on the hippocampus but gradually sh...