iiinova — where your digital self keeps evolving

Reposted by Ismael Hernández Núñez

Levi Todd @levi-todd.bsky.social · 27/08/2026

First paper entirely from our lab is out in the wild! We tested if reprogramming still works in the aged CNS and found the aged retina blocks neurogenesis both intrinsically in Müller glia and through exacerbated inflammation. Then point at some ways to overcome this. www.pnas.org/doi/10.1073/...

pnas.org

Aging limits neuronal regeneration from glia in the mouse retina | PNAS

Reprogramming resident glia into neurons holds great therapeutic promise for neurodegenerative diseases across the central nervous system, yet thes...

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Ismael Hernández Núñez @ismaelhdeznunez.bsky.social · 17/07/2026

Honored to receive the Postdoc Winston Fellow Competition Award from the Department of Ophthalmology at WashU. This award followed my presentation on the requirement of DNA demethylation for retinal development, cell‑fate specification, differentiation, and function. The best is yet to come!

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Reposted by Ismael Hernández Núñez

International Society of Developmental Biology @isdb.bsky.social · 31/10/2025

In the spirit 👻 of Freaky Friday 🎃, here is a beautiful yet eery video of zebrafish retina development showing horizontal cells (🔵) finding their way out of the crowded amacrine (🟠) layer to settle beneath the photoreceptors. Happy #Halloween! 🎥: PhD student Rae Wong from the @nordenlab.bsky.social

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Reposted by Ismael Hernández Núñez

Pranav Seth @thebuddhabird93.bsky.social · 20/03/2026

For today’s #FluorescenceFriday, the #rods clearly chose chaos What you’re looking at are long, beautifully coiled outer segments of rod #photoreceptors… basically the retina showing off its inner spaghetti aesthetic. Elegant, tangled, and absolutely essential for seeing in low light.

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Reposted by Ismael Hernández Núñez

Dr. Brittany J. Carr @drbjcarr.bsky.social · 17/03/2026

Looking through old photos and found this beauty. Frog rods, labelled with GFP under a XOP promoter (inner segment, orange) and wheat germ agglutinin (outer segments, cyan). I love how you can see the holes where the mitochondria are packed near the top of the inner segment (the ellipsoid zone). 🧪🐸

Frog photoreceptors showing a blue outer segment and a bright orange inner segment. Near the top of the orange inner segment is an area with small holes, where mitochondria are packed in very tightly to support the metabolic needs of outer segment synthesis. This area is called the ellipsoid.

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Reposted by Ismael Hernández Núñez

Ryan MacDonald @macdonaldlab.bsky.social · 03/03/2026

Excited to share our new manuscript from the Yoshimatsu and MacDonald labs. www.biorxiv.org/content/10.6.... We found that my favourite glial cells can regulate local retinoic acid signalling to specialise cone photoreceptors for high acuity visual function.

Muller glia (green) regulate local retinoic acid signalling to specialise photoreceptor outer segments (magenta)for high acuity visual function

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Reposted by Ismael Hernández Núñez

Españoles Científicos en Estados Unidos (ECUSA) @comunidadecusa.bsky.social · 15/10/2025

ECUSA Midwest celebrará su II Noche Blanca de la Ciencia el 15 de noviembre en el Instituto Cervantes de Chicago. 📅 Escanea los QR para consultar la agenda completa y registrarte en el evento. 📸 Este año lanzamos un concurso de fotografía infantil con 🎁 tres premios para las mejores fotos.

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Reposted by Ismael Hernández Núñez

Pranav Seth @thebuddhabird93.bsky.social · 04/09/2025

#FluorescenceFriday The #seahorse #retina shows off its beauty — stunning stratification in the inner nuclear and inner #plexiform layers, with rod #bipolar terminals forming a brilliant band. #Vertebrate retinas: the same basic plan, yet each species adds its own twist. Its so fascinating.

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Reposted by Ismael Hernández Núñez

Pranav Seth @thebuddhabird93.bsky.social · 12/09/2025

#FluorescenceFriday #Seahorse retina stained with #GNB3 (green) + #DAPI (cyan). GNB3 labels cone photoreceptors + ON #bipolarcells, tracing pathways from outer to inner retina. Amazing to see conserved visual #circuits in this non-traditional model

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Reposted by Ismael Hernández Núñez

Levi Todd @levi-todd.bsky.social · 11/05/2025

We recently wrote a review about neuroimmune interactions in retinal repair. We dive into the literature regarding immune influences in Muller glia reprogramming, cell transplantation, and axon regeneration. Hopefully its useful, free link: authors.elsevier.com/a/1k-FL4pAsj...

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Ismael Hernández Núñez @ismaelhdeznunez.bsky.social · 07/02/2025

Two days after our preprint in the role of active DNA methylation in retinal development... Happy to share our last paper from my former lab. SnRNA-seq atlas of the postnatal shark retina!! www.nature.com/articles/s41...

nature.com

A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula - Scientific Data

Scientific Data - A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula

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