Thalamocortical projections contribute to the spatial organization and functional hierarchies of the mammalian cortex. Primary sensory cortices receive topographically segregated information from firs...

Cerebrospinal fluid (CSF) is integral to brain function. CSF provides mechanical support for the brain and helps distribute nutrients, neurotransmitters and metabolites throughout the central nervous ...

Nature Communications - The role of glutamate-driven inhibition in neural computations and animal behavior is not fully understood. This study reveals that group III metabotropic glutamate...

Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates an “immune code” that, when presented by meningeal antigen-presenting cells, instructs T cells to safeguard neural homeostasis. They review how inflammation, aging, and neurodegeneration disrupt this finely tuned process and highlight emerging therapeutic opportunities.

In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Nature Reviews Immunology - In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to...

Reverse engineering the control law used by schooling fish provides an effective and robust algorithm for robotic pursuit.

Cerebrospinal fluid (CSF) is integral to brain function. CSF provides mechanical support for the brain and helps distribute nutrients, neurotransmitters and metabolites throughout the central nervous ...

Jeong et al. show that the zebrafish choroid plexus has conserved anatomical features with mammals and expresses transporters involved in cerebrospinal fluid secretion. By using chemogenetics, they re...

The brain uses a specialized system to transport cerebrospinal fluid (CSF), consisting of interconnected ventricles lined by motile ciliated ependymal…

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