iiinova — where your digital self keeps evolving

Reposted by Marina Venero Galanternik

Jeff Farrell @jeffreyafarrell.bsky.social · 13/06/2025

If you love Daniocell, but wish it could generate analyses specific to YOUR genes & cell types of interest, check out DaniocellDesktop - a new point-and-click app for Mac and Windows that enables reanalysis of the Daniocell data without programming: daniocell.nichd.nih.gov/desktop/ (1/4)

48141

Reposted by Marina Venero Galanternik

Siegenthaler Lab @siegenthalerlab.bsky.social · 20/04/2025

Great new work led by @biomarina-vg.bsky.social on zebrafish meninges! Particularly 🤩 is the descriptions of ependymin-expressing meningeal cells (not a fibroblast!) & ablation studies showing their essential role in viability. So much more to learn! Congrats Marina & team on this great work! 🦓🐟🧠

Adult zebrafish possess complex multilayered cephalic meninges. Transmission electron micrograph (TEM) images of transverse sections through the dorsal heads of adult zebrafish, at the level of the optic tecta. A, Pseudocolored overview image of the cephalic meninges, revealing multiple tissue layers between the skull and the brain parenchyma. B, Dorsal surface of a dissected adult zebrafish brain, showing the leptomeninges partially peeling away from the underlying brain parenchyma. C, Higher magnification image of the boxed region in panel B, showing multiple leptomeningeal cell layers separated by membrane bilayers (red arrowheads), delimited ventrally by a well-defined basal lamina (pseudocolored purple). D, Nucleated red blood cell-containing blood vessel embedded within the leptomeninges, with desmosomes and junctions connecting individual endothelial cells (arrows). E, Higher magnification image of the boxed region in panel D, showing a portion of the vessel wall with a characteristic endothelial cell-cell junction (arrow). F, Higher magnification image of collagen fibers in the adult zebrafish leptomeninges. G, Pseudocolored overview image of the cephalic meninges, showing separated heavily pigment dura mater (dural meninges) and leptomeninges. multiple tissue layers (pseudocolored) between the skull and the brain parenchyma. H, Higher magnification image of the boxed region in panel G, showing bilayered dural meninges with periosteal dura adjacent to the skull with an underlying meningeal dural cell layer with numerous large melanophore pigment granules (arrows). Scale bars = 3 µm (A), 4 µm (B,G), 1 µm (C,H), 2 µm (D), 0.3 µm (E), and 0.2 µm (F).

M, Dorsal view of an adult casper zebrafish head with the optic tectum and cerebellum clearly visible through the thin, translucent skull. The yellow box shows the approximate region depicted in panels N and O. N,O, Confocal images of the meninges imaged through the intact skull of a living Tg(mrc1a:egfp)y251, Tg(epd:mcherry)y715 double transgenic adult zebrafish, showing (N) mrc1a:egfp-positive FGPs and lymphatics (green) and epd:mcherry-positive LBCs (magenta), or (O) only epd:mcherry-positive LBCs (magenta). P, High-resolution, high magnification confocal Z-stack through the leptomeninges on the surface of a dissected Tg(mrc1a:egfp)y251, Tg(epd:mcherry)y715 double transgenic adult zebrafish brain, showing LBCs (magenta) and FGPs (green). The large center image is a dorsal XY view of the reconstructed image stack, and the images below and to the right show single-plane XZ and YZ views along the planes noted by the dashed lines (xz-1, xz-2, yz).

63911

Reposted by Marina Venero Galanternik

Dan 🐟 C @zebrafish007.bsky.social · 03/04/2025

We recently described the Axillary Lymphoid Organ (ALO) in the #Zebrafish. It's on the OUTSIDE of the fish, making it great for imaging! Learn more by checking out our paper in @jem.org rupress.org/jem/article-...

26021

Reposted by Marina Venero Galanternik

Journal of Experimental Medicine @jem.org · 01/04/2025

New: @zebrafish007.bsky.social, @zebrafishmk.bsky.social et al. #WeinsteinLab describe a previously uncharacterized external, experimentally accessible secondary lymphoid organ in the #zebrafish located above the pectoral fin. rupress.org/jem/article/...

0229

Reposted by Marina Venero Galanternik

Dan 🐟 C @zebrafish007.bsky.social · 02/04/2025

Excited to see our work describing an external immune organ in the #zebrafish published in JEM! Big thanks to Aurora Kraus and @zebrafishmk.bsky.social and all of our other amazing collaborators including @edanfoley.bsky.social @biomarina-vg.bsky.social #WeinsteinLab rupress.org/jem/article-... 🧪

06716

Marina Venero Galanternik @biomarina-vg.bsky.social · 28/03/2025

An amazing scientist, mentor and human! Congratulations Brant!

020

Reposted by Marina Venero Galanternik

Karen S Wilcox, PhD (she/her) @karenswilcoxphd.bsky.social · 27/03/2025

We have lost a grant that is used to study the very real, and not imagined, health care disparities that exist across our state. Including the impacts of air pollution that reduce life expectancy by 10 years on the west side of SLC. #shameful #academicsky #MedicalSky www.sltrib.com/news/educati...

sltrib.com

Trump admin cuts University of Utah funding that institute used to research health disparities, citing DEI

The Trump administration has cut funding for a University of Utah research institute because work there focused on health disparities, including skin cancer in rural communities and brain injuries in ...

12115

Reposted by Marina Venero Galanternik

The New York Times @nytimes.com · 13/03/2025

Breaking News: A judge ordered the rehiring of thousands of probationary workers across six federal agencies, saying their firings were based on a “sham.” Follow live updates. nyti.ms/422hhPg

A large crowd of protesters in front of the U.S. Capitol building in Washington in February. A headline reads: "Judge Orders Thousands of Federal Workers Reinstated." Photo by Tierney L. Cross for The New York Times

321155273330

Reposted by Marina Venero Galanternik

Marina Venero Galanternik @biomarina-vg.bsky.social · 01/03/2025

Join us this Friday March 7th! @marchforsciencemn.bsky.social

051