Odor Gun tribute. Contribute to JohnstonLab/Whiff-Cannon-4000 development by creating an account on GitHub.

Overview of the RoleAre you an ambitious researcher looking for your next challenge? Do you have an established background in Neuroscience? Do you want to further your career in one of the UK’s leadin...

Sensory processing is dynamically tuned by internal state, yet how metabolic signals reshape the earliest stages of sensory circuits remains poorly understood. Here we identify a circuit mechanism by which satiety suppresses olfactory sensitivity at the first central synapse in the mouse olfactory bulb. Using a within-animal paradigm modelling fasted and glucose-induced sated states, we show that satiety impairs food-finding behaviour and reduces olfactory receptor neuron input to the olfactory bulb. Periglomerular (PG) cells, which co-express insulin receptors and the potassium channel Kv1.3, mediate this effect: insulin inhibits the low-voltage-activated Kv1.3 current in PG cells, increasing their spontaneous and odour-evoked activity. This heightened PG cell activity drives enhanced presynaptic inhibition of olfactory receptor neuron terminals, dampening sensory input before it reaches mitral cells. These findings establish insulin-dependent presynaptic inhibition of PG cells as a key locus of state-dependent sensory gain control. ### Competing Interest Statement The authors have declared no competing interest. Medical Research Council, https://ror.org/03x94j517, MR/V003747/1 Biotechnology and Biological Sciences Research Council, BB/ Z51679X/1

Overview of the RoleAre you an ambitious researcher looking for your next challenge? Do you have an established background in Neuroscience? Do you want to further your career in one of the UK’s leadin...

Animals navigate odor plumes by exploiting dynamic and intermittent cues. Here, the authors show that mice can discriminate among different fluctuating odor signals, and characterize their neural enco...

Salary: Grade 8 (£51,753 – £59,966 p.a.)This role will be based on the university campus, with scope for it to be undertaken in a hybrid manner. We are also open to discussing flexible working arrange...

Salary: Grade 8 (£51,753 – £59,966 p.a.)This role will be based on the university campus, with scope for it to be undertaken in a hybrid manner. We are also open to discussing flexible working arrange...

Project opportunity - Metabolic regulation of neural circuits controlling cognition and metabolism at the University of Leeds

SeeDB-Live is a tissue-clearing approach for live samples such as tissue slices or the in vivo brain. It improves image quality while having minimal effects on electrophysiological properties of neuro...

Around the world, governments are demanding that research funding follow broader political priorities. They should be careful what they wish for.

Project opportunity - Leeds Doctoral Scholarships 2026 at the University of Leeds

Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups...

Sensory systems must perform the dual and opposing tasks of being sensitive to weak stimuli while also maintaining information content in dense and variable sensory landscapes. This occurs in the olfa...

Sensory systems enable organisms to detect and respond to environmental signals relevant for their survival and reproduction. A crucial aspect of any sensory signal is its intensity; understanding how...

All optical physiology in vivo provides a conduit for investigating the function of neural circuits in 3-D. Here, we report a new strategy for flexible, axially-decoupled photo-stimulation and two pho...

Nature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...

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People with changes in the overall sensory experience of food often complain of taste disturbances, although the problem is normally caused by the loss of aroma in the food (thus an olfactory disorder...

Leeds says Elon Musk’s social media site “no longer aligns with our university values”

Human piriform and mediotemporal neurons encode odours, and signal how we perceive, rate and identify scents.

Learning-induced changes in primary sensory neurons support concentration-invariant perception of an odor.

Parallel and interfering neuronal circuits are responsible for operant and classical learning.

<p>The Web of Science, a major commercial indexing service of scientific journals operated by Clarivate, recently decided to remove eLife from its Science Citation Index Expanded (SCIE). eLife will on...