<em>S. maltophilia</em> Bloodstream Infection Outbreak

National Emerging Special Pathogens Training and Education Center

MicuRx Pharmaceuticals has received FDA clearance to begin a phase 2a clinical trial of MRX-5, a novel oral antibacterial therapy for patients with Mycobacterium abscessus pulmonary disease.

Timothy Jenkins, MD, talks about how these important tests are being overly used for respiratory and gastrointestinal presentations and strategies his institution, Denver Health, is employing to reduc...

Among patients with a hospital-acquired or health-care-associated Gram-negative bloodstream infection, cefiderocol resulted in non-inferior 14-day mortality compared with standard of care. Adverse eve...

Fungal meningitis outbreaks are rare and entail high mortality rates. Beginning May 2023, we investigated fungal meningitis caused by Fusarium solani species complex occurring in U.S. patients who received epidural anesthesia in Matamoros, Mexico.

The BL/BLI combination drugs, ceftazidime/avibactam, meropenem/vaborbactam, and imipenem/relebactam, have proven especially useful for treating carbapenemase producing, carbapenem resistant organisms (CRO), specifically Klebsiella pneumoniae carbapenemases (KPCs).

The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy partnered with the society’s Transplant Infectious Diseases Special Interest Group to update its previ...

(A post inspired by years of doing eConsults, an extremely common query about hepatitis B testing, and the latest BritBox series, “Core Antibody Confidential,” starring a grizzled detective with a fad...

We previously reported results of an in-depth study of management practices to prevent healthcare-associated infections. Here we describe the development of an online toolkit containing resources that...

This multicenter study highlights the critical role of ID pharmacists in supporting ID consult services, with 89% of 1,518 curbside inquiries from ID clinicians resulting in clinical management changes as recommended by the pharmacist. These findings emphasize the necessity of ID pharmacists in optimizing multidisciplinary patient care.

In this study of 4,240 GN-BSI episodes during 2019 from 24 U.S. hospitals, the median duration of therapy was 12 days (IQR 9-15); 59% were treated for >10 days. There was marked variability in treatment durations across hospitals.

Nocardia is a genus of gram-positive, partially acid-fast bacilli that typically infect people with chronic lung disease or immunocompromised states.

Comparison of intravenous vs intravenous with step-down to oral antibiotic treatment course for Streptococcus and Enterococcus bloodstream infections - Volume 5 Issue 1

The impact of the COVID-19 pandemic on methicillin-resistant Staphylococcus aureus (MRSA) bacteremia incidence compared to pre-pandemic trends is unknown.

YouTube video by NEJM Group

Rifaquizinone is a dual-pharmacophore antibiotic combining rifamycin and a fluoroquinolone-like compound, showing strong bactericidal activity against resistant Staphylococcus aureus strains and biofi...

Fosmanogepix (FMGX) inhibits glycosylphosphatidylinositol anchored cell wall transfer protein 1, essential for anchoring mannoproteins to fungal cell wall, critical for host invasion.

Monkeypox virus (MPXV), the etiologic agent of mpox, is a DNA virus that may persist on surfaces, contributing to fomite-mediated transmission.

Fevers of unknown origin, undifferentiated illnesses in returning travelers or immunocompromised hosts, complex surgical infections, and extensively drug-r

This survey study compares demographic characteristics, beliefs, and antibiotic preferences of US adults who frequently use antibiotics with those who have not used antibiotics over the past year.

Solid organ transplant recipients have increased vulnerability both to infection-related mortality and harms secondary to intemperate antimicrobial use. Th

Intravenous drug use (IVDU) significantly increases the risk of infective endocarditis (IE). This study evaluates the 2023 Duke-International Society of Cardiovascular Infectious Diseases (ISCVID) criteria for diagnosing IE in patients with a history of IVDU.

Protracted cluster of Group A Streptococcal infection among individuals receiving wound care in the community, North East England, 2022: an outbreak report - Volume 5 Issue 1

ABSTRACT As routine testing of clinical isolates for extended-spectrum β-lactamase (ESBL) production (screen plus phenotypic confirmatory testing) is no longer required by the Clinical and Laboratory ...

A persistent sink reservoir as a potential source of Pseudomonas aeruginosa infections in pediatric oncology patients - Volume 5 Issue 1

Information about the 2024-2025 dengue outbreak.