Two studies show that the ER-associated protein CLN8 catalyses the acyl CoA-dependent acylation of glycerophosphoglycerol, producing lysophosphatidylglycerol, which is then converted into BMP. These r...

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Cells maintain membrane function by actively balancing the molecular shape of their lipids. Milshteyn et al. find that, when subjected to high hydrostatic pressure, yeast and human cells, but not bact...

The yeast vacuole membrane forms ordered microdomains that facilitate microlipophagy under nutrient limitation. We previously found that this process …

Understanding how lipids and proteins interact in living cells is a long-standing challenge. Coupling localized lipid production with proximity proteomics, Tei et al. identified transporters that act ...

Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

Scientists have long wanted to get a closer look at the movement of lipids around a cell, but it’s tough to visualize with traditional light microscopy. UC San Diego researchers have unveiled a new technology with the power to see cells in unprecedented detail.

P116 is an adaptive, all-in-one lipid acquisition machinery fit for any host environment.

Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.