dlvr.it
EBAMP: An efficient de novo broad-spectrum antimicrobial peptide discovery framework
Zhao et al. propose EBAMP, a generative-discriminative framework for de novo design of broad-spectrum antimicrobial peptides (AMPs) targeting both bacteria and fungi. EBAMP achieves a high positive rate (37.5%), exhibiting strong antimicrobial activity against multidrug-resistant pathogens with low toxicity, offering a promising strategy against antibiotic resistance.