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Alessio Fragasso

@alessiofragasso.bsky.social
112 followers 120 following 7 posts

Postdoc fellow in Jacobs-Wagner lab at Stanford University, former PhD in Cees Dekker lab at TU Delft | quantitative biology, antimicrobial peptides, innate immunity, biomimetic nanopores, synthetic biology

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Reposted by Alessio Fragasso
Cees Dekker @ceesdekker.bsky.social · 29/09/2026
Here's our latest #CDlab paper in Nature Comm: a study of nucleocytoplasmic transport via nuclear pore complexes (NPCs), involving designer Nups, biomimetic NPCs, condensates, extensive MD simulations. Great collaboration with particularly the Onck lab. www.nature.com/articles/s41...
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Alessio Fragasso @alessiofragasso.bsky.social · 02/10/2026
Our designer FG-Nups paper is out in Nature Comm 🥳 (after several years in the making 😅) We designed synthetic FG-Nup mimics and combined in-vitro reconstitution with MD to see how sequence shapes the nuclear pore's selective barrier. Huge thanks to all coauthors! www.nature.com/articles/s41...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 13/09/2026
#EMBOBacNet Keynote by Christine Jacobs-Wagner on From governing principles of bacterial cell replication to innate immune strategies and antimicrobials
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Gabriel Neurohr @gabrielneurohr.bsky.social · 18/06/2026
Come and join us next week to hear from Christine Jacobs-Wagner how cells bring order into chaos.
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Xin Shi @xinshi-o.bsky.social · 18/04/2025
🚨We have a 4-year ERC-funded PhD position available in the beautiful city of Leuven, Belgium, for building artificial nanomachines in lipid membranes. Check out the details and apply here: www.kuleuven.be/personeel/jo... Feel free to email me for more information!
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Sonja Schmid @scisonja.bsky.social · 31/07/2025
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭: #nanopores #smFRET #biomolecular #dynamics #singleMolecules We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech. Please share broadly, thank you!🤝 schmid.chemie.unibas.ch
schmid.chemie.unibas.ch
Home | Research Group Schmid | University of Basel
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JacobsWagnerLab @jacobswagnerlab.bsky.social · 03/11/2025
Thrilled to share our latest publication led by amazing Yashna Thappeta & @silviajcanasd.bsky.social + collab. w/ Cegelski lab. We show that glycogen phase separation leads to asymmetric division and cytoplasmic content rearrangement in E. coli exiting exponential phase due to nutrient depletion.
embopress.org
Glycogen phase-separation drives macromolecular rearrangement and asymmetric division in E. coli | The EMBO Journal
imageimageSubcellular organization of bacterial cells transitioning from exponential to stationary phase has not been well investigated. This study shows that transition-phase E. coli cells exhibit as...
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Reposted by Alessio Fragasso
JacobsWagnerLab @jacobswagnerlab.bsky.social · 19/10/2025
Hello! The Jacobs-Wagner lab is finally on Bluesky. We’re excited to celebrate science (and scientists!), share our research, and interact with the community. We look forward to connecting with friends and colleagues across the world.
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Cees Dekker @ceesdekker.bsky.social · 13/08/2025
WORK! I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects: - Nanopore protein sequencing - Archaeal CDV cell division - Microfluidics for synthetic cells - Nuclear Pore Complex - Origami mimics of peroxisomes Please apply! ceesdekkerlab.nl/come-join-us/ RT=👍
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Alessio Fragasso @alessiofragasso.bsky.social · 04/07/2025
What an amazing time at the EMBO Fellows Meeting! Honored to be part of such an inspiring community, had a lot of fun connecting with this group of incredible researchers and hear about their science. A big thank you to the #EMBO organizers! 🤩
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EMBO @embo.org · 30/06/2025
The EMBO Fellows’ Meeting 2025 is taking place in Heidelberg, DE from 27 June–1 July. Over 100 EMBO Fellows from 30+ countries will present their projects, #network, receive #training and #mentoring, speak with EMBO Press editors and learn about new EMBO #policy and #sustainability initiatives. 🧪
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William DeWitt @wsdewitt.github.io · 08/06/2025
I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.
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Martin Weigert @maweigert.bsky.social · 06/06/2025
Out today in @natmethods.nature.com : Spotiflow, our transcript localization method for imaging-based spatial transcriptomics. Led by amazing PhD student @albertdm.bsky.social, joint work w @gioelelamanno.bsky.social at EPFL / @scadsai.bsky.social www.nature.com/articles/s41... rdcu.be/epIB7
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European Research Council (ERC) @erc.europa.eu · 19/05/2025
Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe? ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields. Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik #ChooseEurope
youtu.be
ERC Grants: EU funding for your bottom-up research proposal (2025)
YouTube video by EURAXESS North America
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 19/05/2025
Webinar TOMORROW at 16:00 CET/10:00 AM EDT regarding a breakthrough Nature paper from Prof. Yifat Merbl's group. Registration if FREE! Just sign up to become an iAMPNet member and register. Use the links below! www.iampnet.com/become-a-mem... events.teams.microsoft.com/event/57387b...
nature.com
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
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William DeWitt @wsdewitt.github.io · 13/05/2025
“There is so much beauty in what we can learn through science, in how complicated life is, and in trying to understand how it works. It’s what motivates me to wake up every morning.”
nytimes.com
Opinion | I Came to Study Aging. Now I’m Trapped in ICE Detention.
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Kevin Whitley @kevindwhitley.bsky.social · 06/05/2025
Postdoc position available! This is a 2-year post funded by the Academy of Medical Sciences. You'll be based in the Centre for Bacterial Cell Biology here in Newcastle, using super-resolution microscopy to look at the bacterial cell wall. 🔬🦠 Please re-post 🙏 www.jobs.ac.uk/job/DMY885/r...
jobs.ac.uk
Research Assistant/Associate - Mapping the Bacterial Cell Wall with Super-resolution Microscopy at Newcastle University
Apply for the Research Assistant/Associate - Mapping the Bacterial Cell Wall with Super-resolution Microscopy role on jobs.ac.uk, the top job board for academic positions in higher education. View det...
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HMS Image Analysis Collaboratory @hms-iac.bsky.social · 08/05/2025
💻 Apply to our beginner-friendly Boston Bioimage Analysis Course! Get started with Python and learn to analyze fluorescence microscopy images — no coding experience required! Fee waivers available thanks to funding from @bioimagingna.bsky.social! 🗓️ Apply June 1st! iac.hms.harvard.edu/bobiac/2025/
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Cees Dekker @ceesdekker.bsky.social · 13/03/2025
We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes. Check it out and apply: ceesdekkerlab.nl/come-join-us/ RT=nice!
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Wim Meijer @wimgmeijer.bsky.social · 26/04/2025
Bacteria living in the human gut are found to evolve persistent resistance after brief exposure to antibiotics. Factors that promote this evolution have been identified, highlighting the gut as a potential hotspot for this process. 🧪🦠 www.nature.com/articles/d41...
nature.com
Tracking the evolution and persistence of antibiotic resistance in the human gut
A genomic study of gut microbes during antibiotic use finds selective sweeps in a DNA gyrase gene that drive resistance.
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Alessio Fragasso @alessiofragasso.bsky.social · 25/04/2025
Out now! @biorxivpreprint.bsky.social from my PhD at #CDlab We design, experimentally test, and simulate a library of designer FG-nucleoporins. We identify key biophysical properties of their amino acid sequence that tune their selective barrier function. Congrats to all co-authors! 🥳
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Cell - a Cell Press journal @cp-cell.bsky.social · 21/04/2025
Now online! Tissue geometry spatiotemporally drives bacterial infections
dlvr.it
Tissue geometry spatiotemporally drives bacterial infections
Tissue-geometry-regulated cellular traction forces trigger the activation of Piezo1 and its co-localization with bacteria to facilitate the formation of specific bacterial invasion patterns to promote infection.
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brunolemaitre.bsky.social @brunolemaitre.bsky.social · 21/03/2025
Does marrying a fellow scientist boost your career? In academia, homogamous couples—where both partners are scientists—are common, especially among top achievers. But who benefits more? Let’s dive into our latest research!
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European Research Council (ERC) @erc.europa.eu · 20/04/2025
🦠 Most #bacteria form #biofilms, protective communities that resist #antibiotics. Petya Krasteva's research explores the structure & behaviour of these biofilms, hoping to develop new #antimicrobial strategies. Read more 👉 buff.ly/YajqauG @krastevalab.bsky.social @iecb.bsky.social @CNRS.fr
buff.ly
Deciphering the formation of cooperative multicellular biofilms
Bacterial films are a hazard throughout the healthcare system, and as antibiotic resistance increases there is an even greater imperative...
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Xin Shi @xinshi-o.bsky.social · 18/04/2025
🚨We have a 4-year ERC-funded PhD position available in the beautiful city of Leuven, Belgium, for building artificial nanomachines in lipid membranes. Check out the details and apply here: www.kuleuven.be/personeel/jo... Feel free to email me for more information!
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Alessio Fragasso @alessiofragasso.bsky.social · 12/04/2025
Excited to share our first big story from my postdoc @JacobsWagnerLab, now on biorxiv: biorxiv.org/content/10.1... We build a single-cell pipeline to functionally classify antimicrobial peptides and peptidomimetics based on phenotypes Huge thanks to Christine and coauthors! 🥳🤩
biorxiv.org
Time-resolved phenotyping at subcellular resolution reveals shared principles and key trade-offs across antimicrobial peptide activities
Cationic antimicrobial peptides are a large family of host defense molecules with diverse sequences and structures. Here, we present a computational and experimental pipeline for quantifying the membr...
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