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International AMP Network (iAMPNet)

@iampnetwork.bsky.social
238 followers 251 following 22 posts

We aim to help connect scientists studying antimicrobial peptides (AMPs) across industry and academia through webinars, mentorships, and networking opportunities. Join us at www.iampnet.com!

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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 16/06/2026
🚨Attention all AMP researchers🚨 Registration for the 2027 Gordon Conference on AMPs is now open! Don't miss this awesome opportunity to meet and discuss AMP research in Italy early next year. We hope to see you all there!
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 08/06/2026
We have an exciting Webinar planned this month! Join us on June 24th at 10 AM EDT for our lightning round! Five short talks on AMPs from early career researchers. Free registration will be open soon at iampnet.com. If you aren't a member yet, it is also free to sign up! Hope to see you there!
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 14/04/2026
Please join us April 21st for our next exciting webinar let by Dr. Aaron Lau and Dr. Yoann Roupioz focused on "Improving the functioning and detection of AMPs". As always, registration and membership in iAMPNet is FREE! So there is no excuse not to join! Visit iampnet.com and click webinars.
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 25/03/2026
We are having a new webinar next month! See details below! Registration and membership is always free!
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Reposted by International AMP Network (iAMPNet)
Claus Wilke @clauswilke.com · 11/03/2026
New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/ www.biorxiv.org/content/10.6...
biorxiv.org
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 11/03/2026
Don't miss our next webinar featuring Dr. Elisa Casadei and Dr. Christopher A. Rice on March 24th! They'll speak on AMP Biology Across Systems! Membership and registration is Free just visit: www.iampnet.com
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Reposted by International AMP Network (iAMPNet)
Mark A. Hanson @hansonmark.bsky.social · 06/03/2026
Pleased to finally share this fun collab that began at #Ento23 @cedricaumont.bsky.social presented & I had seen NCBI annotated some cockroach genomes as "contaminated." Turns out NCBI & I were wrong (much more fun). Horizontal transfer of an #AntimicrobialPeptide across insects bit.ly/DrsHGT 1/🧵
A phylogenetic tree of insects is shown annotating the presence or absence of a an antimicrobial peptide gene across winged insectsVarious phylogenetic secondary loss events are mapped to a tree of insects to explain the parsimony calculations necessary to explain the diversity of insect Drosomycin antimicrobial peptide genesAntimicrobial peptides (AMPs) are key defence molecules of the innate immune system of plants and animals. Understanding the evolutionary origins of AMPs can help to explain how immune systems acquire novelty and vary in their defensive capabilities. However, AMPs evolve rapidly, and so the origins of similar AMPs across organisms is often unclear. Furthermore, false negatives due to low search sensitivity are common and can hinder confident annotations about true absences. Due to these difficulties, understanding whether similar AMP genes found in diverse organisms represent ancestral molecules or evolutionary novelties has been challenging. In this report, we present evidence of
horizontal gene transfer (HGT) of the antifungal peptide gene Drosomycin across insects. We show that in Diptera, the presence of Drosomycin is restricted to the Melanogaster group and additionally the
distant relative Drosophila busckii. We go on to recover Drosomycin genes in cockroaches (Blattodea), mantises (Mantodea), one katydid (Orthoptera), various beetles (Coleoptera), and a recently acquired
pseudogenized Drosomycin locus in Liposcelis booklice (Psocodea), but no other insects. Explaining this diversity through shared ancestry requires at least 50 independent loss events, or just seven HGT
events. Previous studies have suggested that similar AMPs found across divergent species reflect conservation from a common ancestor, or due to their small size, that they arose via convergent evolution resulting from pathogen-imposed selection. Our findings suggest horizontal gene transfer can be responsible for the presence of some AMP genes found scattered across the tree of life. By presenting a mechanism through which immune systems can acquire novelty, our study also suggests a possible explanation for certain lineage-specific competencies for defence against infectious disease. While loss of AMP genes is common in certain lineages, here we suggest gain of AMPs can occur just as suddenly.
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Scott Nelson @swnisu.bsky.social · 23/05/2025
Follow along with an open science project on antimicrobial peptide discovery! I'm sharing all data and research notes publicly (doi.org/10.55277/Res...). Our pre-registration, funded through @researchhubf.bsky.social, builds on a recent paper published in their new Journal. 🧪
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Ewa Szczurek @ewaszczurek.bsky.social · 28/03/2025
1. Work on our @erc.europa.eu funded project DOG-AMP and design novel Generative AI methods for antimicrobial peptide discovery! * Advertisement: euraxess.ec.europa.eu/jobs/329758 * More about the project: www.youtube.com/watch?v=_Y-_...
euraxess.ec.europa.eu
Research assistant position in the scientific project Deep optimized generation for antimicrobial peptide discovery (DOG AMP)
Attachment to SOB/ KJ/ DOG-AMP/101125506/2025/1Research assistant position in the scientific projectDeep optimized generation for antimicrobial peptide discovery (DOG AMP) financed by the European Com...
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Julie Karpenko @juliekarpenko.bsky.social · 18/12/2024
I’m excited to share the first chapter of the UNR-1 story! UNR-1 is a red #fluorescent #antimicrobial peptide that stains both Gram- and Gram+ bacteria with high selectivity over eukaryotes. Stay tuned for part two with some fascinating applications! #chembio pubs.acs.org/doi/abs/10.1...
pubs.acs.org
Fluorescent Antimicrobial Peptides Based on Nile Red: Effect of Conjugation Site and Chemistry on Wash-Free Staining of Bacteria
Fluorescent probes for bacterial detection can be obtained by conjugating antimicrobial peptides with fluorescent dyes. However, little is known about the effect of the conjugation site and linker che...
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Reposted by International AMP Network (iAMPNet)
Cell Reports @cp-cellreports.bsky.social · 09/09/2025
EBAMP: An efficient de novo broad-spectrum antimicrobial peptide discovery framework
dlvr.it
EBAMP: An efficient de novo broad-spectrum antimicrobial peptide discovery framework
Zhao et al. propose EBAMP, a generative-discriminative framework for de novo design of broad-spectrum antimicrobial peptides (AMPs) targeting both bacteria and fungi. EBAMP achieves a high positive rate (37.5%), exhibiting strong antimicrobial activity against multidrug-resistant pathogens with low toxicity, offering a promising strategy against antibiotic resistance.
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Microbial Biotechnology (MBT) @microbiotech.bsky.social · 28/01/2026
#MicroSky: ONE HEALTH: Choudhury et al engineered Lactococcus lactis to deliver antimicrobial peptides that selectively target Fusobacterium nucleatum, a key driver of colorectal cancer, reducing biofilms & preserving gut microbiome diversity. doi.org/10.1111/1751...
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Neeloffer Mookherjee @nmookherjee.bsky.social · 26/05/2025
Sharing our latest publication on modulation of IL-17 mediated inflammation by #HostDefencePeptide LL-37 and citrullinated-LL-37 in the context of lung inflammation #Asthma #Immunosky #Immunomodulation #AntimicrobialPeptides pubmed.ncbi.nlm.nih.gov/40410820/
pubmed.ncbi.nlm.nih.gov
LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells - PubMed
Overall, our findings showed that LL-37 and citLL-37 can selectively suppress the abundance of IL-17A/F-mediated LCN-2, a protein that is critical for neutrophil migration in HBEC. These results sugge...
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Justin Randall (Randall Lab, UMKC) @justin-randall.bsky.social · 02/02/2026
Our lab has a new review on beta-hairpin antimicrobial peptide diversity out in @pubs.acs.org as part of the special issue celebrating Robert E. W. Hancock. Please have a look and share! pubs.acs.org/doi/10.1021/...
pubs.acs.org
β-Hairpin Antimicrobial Peptides: Class Diversity and Sequence Analysis
Interest in antimicrobial peptides has increased dramatically over the last few decades as researchers continue to explore their potential as alternatives to small molecules, as well as their applicat...
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 17/11/2025
Get ready to AMP up your knowledge on the history and future of peptides!! In less than 24h we are hosting Prof. Charles L. Bevins for our annual History month!! Register here: events.teams.microsoft.com/event/fa432f...
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 08/09/2025
Don't forget about our 3rd FREE webinar of the year tomorrow! There is still plenty of time to become an iAMPnet member and register at the following links: www.iampnet.com/become-a-mem... www.iampnet.com/s-projects-b...
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 11/08/2025
Don't miss the upcoming iAMPNet Webinar on September 9th! Both iAMPNet membership and webinars are FREE! follow the link below to sign up as a member. If already a member, the webinar registration link is located at the bottom left of the iAMPNet home page! www.iampnet.com/become-a-mem...
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 31/07/2025
Check out this new publication from Dr. Eduardo Cobo's group exploring cathelicidin regulation of goblet cells mucus secretion in Citrobacter rodentium-induced colitis! www.tandfonline.com/doi/full/10....
tandfonline.com
Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis
Colonic goblet cells play a crucial role in mucosal defense by secreting Muc2 mucin and other proteins that entrap and expel enteropathogens. However, the role of innate effectors in the gut like c...
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 19/05/2025
Webinar TOMORROW at 16:00 CET/10:00 AM EDT regarding a breakthrough Nature paper from Prof. Yifat Merbl's group. Registration if FREE! Just sign up to become an iAMPNet member and register. Use the links below! www.iampnet.com/become-a-mem... events.teams.microsoft.com/event/57387b...
nature.com
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 06/05/2025
REMINDER! the 12th International Meeting on AMPs (IMAP) is taking place in Dublin August 25-27. Abstract submission deadlines were just extended. Don't miss out on this awesome meeting! Follow the link below to download the template and submit your abstract! peptideconferences.org/imap2025/pro...
peptideconferences.org
IMAP 2025 Programme & Abstracts
Organisers of academic conferences in the peptide sciences under the auspices of the Royal Society of Chemistry.
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 29/04/2025
Proteasomes: not just cellular trash cans! New in Nature: Prof. Yifat Merbl and team reveal a groundbreaking role for the proteasome in innate immunity. www.nature.com/articles/s41... Prof. Yifat Merbl is speaking at our free webinar May 20th. Register via our website or via following link:
events.teams.microsoft.com
Microsoft Virtual Events Powered by Teams
Microsoft Virtual Events Powered by Teams
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 24/04/2025
Did you get our monthly newsletter? If you are member and did not receive it, check your junk box! We are also excited to announce Prof. Yifat Merbl as our next seminar speaker on May 20th! She'll discuss Proteolysis-Driven Immunity and her recent Nature publication! Visit iampnet.com to attend.
iampnet.com
iAMPNet | international antimicrobial peptide research network
International AntiMicrobial & host defence Peptide Network (www.iampnet.com)
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 12/04/2025
Check out this awesome work from @alessiofragasso.bsky.social and the Jacobs-Wagner lab on single cell AMP classification!
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 11/04/2025
If you would like us to potentially post your AMP related research, please send us a direct message! If you are an iAMP member please let us know in your message and feel free to use #iAMPNet in any AMP related posts!
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 10/04/2025
Abstract submissions for the next International Meeting on Antimicrobial Peptides (IMAP) in Dublin are now open! For more information on how to register follow the link below! peptideconferences.org/imap2025/home
peptideconferences.org
IMAP 2025 Home
The 12th International Meeting on Antimicrobial Peptides
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 09/04/2025
🧬🐸 Frogs to the rescue in the antibiotic resistance crisis? A leap forward for antimicrobial peptide therapy? Definitely worth watching. 🧪🌍 www.sciencedirect.com/science/arti...
sciencedirect.com
Frog-derived synthetic peptides display anti-infective activity against Gram-negative pathogens
Novel antibiotics are urgently needed since bacteria are becoming increasingly resistant to existing antimicrobial drugs. Furthermore, available antib…
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Mark A. Hanson @hansonmark.bsky.social · 09/04/2025
The mechanisms & regulation of insect #antimicrobialpeptides & #HDPs is of wide interest. We now appreciate their function in vivo is much more complex than what's described in vitro. Our primer on insect AMP regulation, evolution & function. Pub: doi.org/10.1016/B978... 🟩OA: bit.ly/MHLH2025 1/n
A diagram of Toll and IMD signalling regulation across insect species, with annotations of insect orthologues for their regulation.A comparison of protein structures for antimicrobial peptides of related gene families across insects, showing commonalities and unifying their naming conventions.A summary of studies to date detailing the regulation of specific AMPs across insect species.
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Irina Bezsonova @irinabezsonova.bsky.social · 15/03/2025
You can download my protein structure-inspired artwork from pdb webpage: pdb101.rcsb.org/sci-art/bezs... @rcsbpdb.bsky.social @pdbeurope.bsky.social #sciart
pdb101.rcsb.org
PDB101: Irina Bezsonova Gallery
PDB-101: Training, Outreach, and Education portal of RCSB PDB
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Mark A. Hanson @hansonmark.bsky.social · 27/02/2025
I've also now made a Starter Pack for the #AntimicrobialPeptide field here: go.bsky.app/JLHHzt1 Please let me know who I am missing! This is a very incomplete list so far. I also expect many will join Bluesky later. I will happily keep populating this list! 📣🧬🦠
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 24/02/2025
At the AMPs GRC? Come stop by our poster later today or chat in person with any of our committee members! iAMPNet is free to join!
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 23/02/2025
Looking forward to seeing everyone at the AMPs GRC this week! Stop by poster #31 to learn more about iAMPNet and consider participating in our Mentorship Program for which we are currently recruiting!
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 15/01/2025
🌟 Kick Off 2025 with Our First Webinar of the Year! 🌟 🎤 Speakers: 🔹 Belinda Omino 🔹 Padmanie Ramotar, M.Sc Presentations will focus on research and mentorship experiences with iAMPNet! 📅 Date: January 28th 🕒 Time: 16:00 – 17:00 CET 💡 Register for free using this link: lnkd.in/eAPh62Mn
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International AMP Network (iAMPNet) @iampnetwork.bsky.social · 14/01/2025
We have migrated over from X! If you are interested in antimicrobial peptide research, please join our membership at www.iampnet.com more to come soon!
iampnet.com
iAMPNet | international antimicrobial peptide research network
International AntiMicrobial & host defence Peptide Network (www.iampnet.com)
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