Sign in

Huma R

@humaribosome.bsky.social
101 followers 38 following 12 posts

I Study Ribosomes and RNA polymerase Former JRF@IISC Kashmiri

PostsRepliesMedia
Reposted by Huma R
Science News @scinews.bsky.social · 21/02/2025
Genetic therapy gives infants life-changing improvements in sight. #TheLancet "Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study" www.thelancet.com/journals/lan...
thelancet.com
Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study
Our findings indicate that young children with AIPL1-related retinal dystrophy benefited substantially from subretinal administration of rAAV8.hRKp.AIPL1, with improved visual acuity and functional vi...
1236
Reposted by Huma R
Nature Synthesis @natsynth.nature.com · 21/02/2025
Now online: Article by Xuelei Su, Zhihao Ding, Ye Hong, Nan Ke, KaKing Yan, Can Li, Yi-Fan Jiang & Ping Yu Fabrication of spin-1/2 Heisenberg antiferromagnetic chains via combined on-surface synthesis and reduction for spinon detection www.nature.com/articles/s44... ($) #ChemSky
nature.com
Fabrication of spin-1/2 Heisenberg antiferromagnetic chains via combined on-surface synthesis and reduction for spinon detection - Nature Synthesis
Spin-1/2 Heisenberg chains are fabricated through on-surface synthesis and reduction. As the chain length increases, the spin excitation gaps decrease, suggesting a gapless state in the thermodynamic ...
022
Reposted by Huma R
NEJM.org @nejm.org · 20/02/2025
A previously healthy 44-year-old woman presented to the oral medicine clinic with an 11-month history of mouth ulcers and blistered lips. The lesions had caused pain while eating, with resultant unintentional weight loss. 1/4 #MedSky #DermSky
Image Challenge
What is the diagnosis?

Top-left panel: Photo of the patient’s lips.
Top-right pannel: Photo of the patient’s tongue.
Bottom-left panel: Photo of the inside of the patient’s mouth.
Bottom-right panel: Direct immunofluorescence of the biopsy specimen.
3143
Reposted by Huma R
Science Magazine @science.org · 10/02/2025
Breaking news: 22 states are suing to block NIH’s cutting of indirect costs. See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v
scim.ag
NIH slashes overhead payments for research, sparking outrage and lawsuit
Move to cut indirect cost rate to 15% could cost universities billions of dollars
5410162
Reposted by Huma R
Science Magazine @science.org · 05/02/2025
Many U.S. science agencies abruptly abandoned normal operations last week to focus on a slew of executive orders from President Donald Trump. The torrent of activity left many researchers bewildered—and fearful of what might come next. scim.ag/4jMPYiY
scim.ag
Trump orders cause chaos at science agencies
Wild week of canceled meetings, program changes, and data purges creates high anxiety
614048
Huma R @humaribosome.bsky.social · 04/02/2025
Congratulations 🎊🎉🍾🎈 @mohammadafsarkhan.bsky.social. It was treat to watch you presenting your interesting work!
030
Reposted by Huma R
Diane Takahashi @diane-takahashi.bsky.social · 04/02/2025
Congratulations to @mohammadafsarkhan.bsky.social for getting the best talk award !!!!
021
Reposted by Huma R
Mehdi Hasan @mehdirhasan.bsky.social · 03/02/2025
“Elon Musk Has Plunged America Into a Constitutional Crisis. He Must Be Stopped.” Powerful and much-needed appraisal from Will Stancil of the meaning of, and fallout from, this weekend’s takeover of the Treasury and USAID by Musk and his minions.
zeteo.com
Elon Musk Has Plunged America Into a Constitutional Crisis. He Must Be Stopped.
The world’s richest man, unelected and unvetted, has taken physical control of US government departments, funding, and secrets.
1353045718
Reposted by Huma R
Nature Portfolio @natureportfolio.nature.com · 21/01/2025
A study in Nature Medicine reports that a surgically implanted brain–computer interface can detect and decode finger movements in a person with paralysis, allowing them to play a video game. #Medsky 🧪
go.nature.com
A high-performance brain–computer interface for finger decoding and quadcopter game control in an individual with paralysis - Nature Medicine
A finger-based brain–computer interface was developed for a person with tetraplegia to allow him to fly a virtual quadcopter, an innovation that can lead to improved social connectedness, recreation and a sense of enablement.
2688
Reposted by Huma R
NEJM.org @nejm.org · 21/01/2025
This paper described the groundbreaking, first gene-editing therapy for sickle cell disease to be approved by the FDA. We now have 2 approved stem cell therapies that can cure sickle cell disease. Revisit the paper: nej.md/33JG0cJ #MedSky #Hematology
On this Day in 2021 

Post-Transcriptional Genetic Silencing of  

BCL11A to Treat Sickle Cell Disease 

Visual representation of “CRISPR-Cas9” from the NEJM Illustrated Glossary. 

The NEJM identity sits at the bottom.
36822
Reposted by Huma R
Nature Portfolio @natureportfolio.nature.com · 03/01/2025
Join us for a webinar in which leaders of the Human Tumor Atlas Network will discuss their latest research that was published across Nature Portfolio journals and the work ahead. Register here: go.nature.com/406Dud5 Browse the collection: go.nature.com/41DXk1y #AcademicSky 🧪
An illustration that is meant to represent the Human Tumor Atlas Network.
0205
Reposted by Huma R
Science Magazine @science.org · 03/01/2025
A new study finds ants best humans at tests of collective intelligence. Learn more: scim.ag/4h2K0ID
26506166
Reposted by Huma R
NEJM.org @nejm.org · 03/01/2025
From March through October 2024, a total of 46 human cases of highly pathogenic avian influenza A(H5N1) virus infections were identified in the United States, with 20 linked to poultry exposure and 25 to dairy cow exposure. Read the full article: nej.md/3VU4R8I  #MedSky #IDSky
nej.md
Highly Pathogenic Avian Influenza A(H5N1) Virus Infections in Humans | NEJM
Highly pathogenic avian influenza A(H5N1) viruses have caused widespread infections in dairy cows and poultry in the United States, with sporadic human cases. We describe characteristics of human A...
13717
Reposted by Huma R
Science Magazine @science.org · 03/01/2025
Five years after #SARSCoV2 surfaced, scientists reflect and look ahead to the next threat. scim.ag/4j4CZsn
scim.ag
COVID 5 years later: Learning from a pandemic many are forgetting
Five years after SARS-CoV-2 surfaced, scientists reflect and look ahead to the next threat
26120
Reposted by Huma R
NEJM.org @nejm.org · 03/01/2025
A 14-year-old patient presented to the ED with a 12-month history of joint pains and a 2-month history of headaches and blurry vision. Link to full case details in comments. Read the full case details in a new Clinical Problem-Solving article: nej.md/4goA6B3 #MedSky
Fundus Examination of the Eyes.
0165
Reposted by Huma R
The Washington Post @washingtonpost.com · 02/01/2025
“Fartleks” -- meaning “speed play” in Swedish -- are an effective way to add intensity to activities, which a growing body of science indicates can make your workouts more beneficial.
wapo.st
Don’t like to exercise? Try this simple, science-backed trick.
‘Fartleks’ are an effective way to add intensity to activities, which a growing body of science indicates can make your workouts more beneficial.
1912414
Reposted by Huma R
Alan Brown @alanbrownhms.bsky.social · 02/01/2025
A reminder that the Brown lab has an opening for a postdoc fellow: brown.hms.harvard.edu/jobs/242. This might suit someone from the #cilia community interested in learning structural biology. Deadline extended to the 10th Jan.
brown.hms.harvard.edu
Postdoctoral fellow | Brown Lab
The Brown lab at Harvard Medical School is seeking a highly motivated postdoctoral fellow to join our team.
01512
Reposted by Huma R
Science Magazine @science.org · 31/12/2024
A Science study from earlier this year in mice identifies chromatin plasticity as a novel form of plasticity important for information encoding. Learn more in this #SciencePerspective:
scim.ag
Epigenetic control of memory formation
A neuron's suitability to participate in a memory trace is modulated by its epigenetic state
0348
Reposted by Huma R
Duet @drduet.bsky.social · 29/12/2024
i aspire to be an engineer If i doesnt became a martyr The attractions of martyrdom are irresistible Debilitating injury, blinding or worse The death is romancing almost all the time under my feet the feet of oppressed i feel honour to die for nation Then to live in perpetual humiliation
192
Reposted by Huma R
Aliya @aliyanazki.bsky.social · 28/12/2024
asyi kalman gaer talvar ti lyokhh shinni maanyen pyetth armaan dilluk/ yelli booz timmav taehreerìch katth, tìm burze vannan gaye naar divaan ~ #Kashmir
042
Reposted by Huma R
Les @les61410.bsky.social · 28/12/2024
3458
Reposted by Huma R
Azad Essa @azadessa.bsky.social · 26/12/2024
India plans on building “the highest train station” in the world in Kashmir. Delhi says it’s about economic growth & development. Kashmiris know it means land dispossession, ecocide and forcing integration with India.
184
Reposted by Huma R
Irfan Amin Malik @irfanaminmalik.bsky.social · 27/12/2024
Finally snow (sheen) is here! #trendingreels #viral #snow #kashmir #weather
031
Reposted by Huma R
The Harbinger @robinoflocksley.bsky.social · 28/12/2024
#HeavySnow forces cancelled flights and brings #Kashmir to a standstill with roads blocked freepresskashmir.news/2024/12/28/h...
freepresskashmir.news
Heavy snowfall brings Kashmir to a standstill: Roads blocked, flights cancelled, and power outages persist | Free Press Kashmir
Srinagar: Heavy snowfall across Kashmir disrupted normal life on Saturday, causing widespread road closures, flight cancellations, and power outages. The season's first major snowfall impacted several...
011
Huma R @humaribosome.bsky.social · 28/12/2024
1896: A woodcarver in Kashmir. Photo - Fred Bremner
030
Reposted by Huma R
Mirza Waheed @mirzawaheed.bsky.social · 28/12/2024
About my new novel Maryam & Son. Out next year.
193
Huma R @humaribosome.bsky.social · 27/12/2024
Seasons first snow fall is here Kashmir is winter wonderland #kashmir #Snow #Holidays
050
Reposted by Huma R
Science Magazine @science.org · 13/12/2024
"In naming ... lenacapavir as the 2024 #BOTY, Science acknowledges the next, but by no means final, step in the drive to fight HIV/AIDS, where the rigors of the laboratory and the needs of humanity are inseparable," writes @holdenthorp.bsky.social in this week's #ScienceEditorial. scim.ag/4g9kjG4
Quote on a red background stating, "... the work to fight HIV/AIDS is far from over." Attributed to H. Holden Thorp, Editor-in-chief, Science journals.
04114
Reposted by Huma R
Stratheia @stratheia.bsky.social · 03/12/2024
Major political parties are using Jammu and Kashmir’s autonomy removal as a bargaining chip—what does this mean for local governance? #Kashmir #KashmirMatters #KashmirInFocus #KashmirGeopolitics #VoicesOfKashmir #JusticeForKashmir #KashmirFuture Read Full Article: stratheia.com/kashmir-a-ja...
stratheia.com
Kashmir- A jackpot lottery! - Stratheia
The political landscape in Jammu and Kashmir raises concerns over disempowerment and the erosion of electoral democracy amid party agendas.
011
Reposted by Huma R
FCDO Answers @fcdo-answers.bsky.social · 03/12/2024
A question on #Kashmir #HumanRights tabled by Sarah Owen on 28-11-2024 has been answered by Catherine West. questions-statements.parliament.uk/…
011
Reposted by Huma R
Foreign Policy @foreignpolicy.com · 27/11/2024
Recent attacks represent a renewal of extremist violence in disputed Kashmir that has for the most part abated in the last few years. What explains this resurgence?
foreignpolicy.com
Is Militancy Surging in Indian-Administered Kashmir?
An uptick in terrorist incidents as a new government settles in raises questions about discontent in the region.
1112
Reposted by Huma R
Viola Tricolor @kaffeehaus.bsky.social · 02/12/2024
This gorgeous papier-mâché tray from around 1850 was apparently made in Kashmir for the European market! More info on its origins & technique see collections.vam.ac.uk/item/O77434/...
Round tray painted in golden hues, depicting floral ornaments including three stylized cypresses. Image and more info: https://collections.vam.ac.uk/item/O77434/tray-unknown/
1112
Reposted by Huma R
Marie Ruiz-Vidal @ruizvidal7.bsky.social · 27/11/2024
© Steve McCurry Fisherman Dai Lake Kashmir 1999
0407
Reposted by Huma R
The Innovation Nutrition @nutrisci.bsky.social · 01/12/2024
Molecular basis of mRNA delivery to the bacterial ribosome. @science.org #scisky #biology #news #science "Visualized the early encounter between a transcribing RNA polymerase and a ribosome, which initiates translation on the nascent mRNA." Read more www.science.org/doi/10.1126/...
063
Reposted by Huma R
erzbergerlab.bsky.social @erzbergerlab.bsky.social · 26/11/2024
New insights into translational control of the translational machinery: Cryo-EM reveals LARP1 binds ribosomes and TOP mRNAs simultaneously—but ribosome binding isn’t required for repressing translation. #CryoEM #ribosome #RNASky #RNABiology www.embopress.org/doi/full/10....
embopress.org
LARP1 binds ribosomes and TOP mRNAs in repressed complexes | The EMBO Journal
imageimageThe LARP1 protein regulates translation and stability of mRNAs characterized by a terminal oligopyrimidine (TOP) motif, which encode most proteins of the translation machinery. This study pr...
081
Reposted by Huma R
Sonhita 🌞 @sonhita.bsky.social · 27/11/2024
Researchers from the John Innes Centre, Durham University and Jagiellonian University used high-resolution cryo-electron microscopy (cryo-EM) to reveal unprecedented mechanical detail of gyrase’s action on DNA. Read the article here www.pnas.org/doi/10.1073/...
youtube.com
Prospects of antibiotic development raised by “Belt and Pulley” discovery in bacterial enzyme
YouTube video by John Innes Centre
022
Reposted by Huma R
Shourya Roy Burman @ssroyburman.bsky.social · 27/11/2024
Through a series of cryo-EM structures, this study shows how an E2 and ubiquitin itself can play a "structural" role to specify ubiquitin linkage. 🧪 Lovely work by Katrina Warner, @moritzhunkeler.bsky.social @kheewoongbaek.bsky.social, @katherinedonovan.bsky.social and others in the Fischer Lab!
0125
Reposted by Huma R
Antony Lurie @antonylurie.bsky.social · 27/11/2024
The first story from my PhD is now available on bioRxiv!: www.biorxiv.org/content/10.1... We determined structures of a LRRC8A:D VRAC by cryo-EM and explored the role of pore lipids in their gating. Huge thanks to the whole Brohawn lab, and especially to Steve @stevebrohawn.bsky.social and David!
2184
Reposted by Huma R
The Lewis Lab @peterlewislab.bsky.social · 27/11/2024
New paper on how SWR1 targets promoters and facilitates H2A.Z exchange. Cryo-EM shows open ATPase conformation enabling DNA sliding, with Swc2 orienting on nucleosomes and Swc3 mediating recruitment. Acetyl-histone marks guide SWR1 to +1 nucleosomes. www.sciencedirect.com/science/arti...
281
Reposted by Huma R
Jamie Blaza @jnb-lab.bsky.social · 29/11/2024
We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!
22725
Reposted by Huma R
LolandLab @lolandlab.bsky.social · 29/11/2024
Interested in ATP synthetases? Here is a 2.8 Å cryo-EM structure of the Vo domain of V/A-ATPase from Thermus thermophilus. www.nature.com/articles/s41...
nature.com
Rotary mechanism of the prokaryotic Vo motor driven by proton motive force - Nature Communications
Here the authors determine a 2.8 Å cryo-EM structure of the Vo domain of V/A-ATPase, showing how protonation of Glu residues in the c12-ring drives ATP synthesis. Molecular dynamics simulations highli...
121
Reposted by Huma R
Lucas Farnung @lucas.farnunglab.com · 08/12/2023
Our paper on the structure of the complete Rpd3S-nucleosome complex is now out in Nat Comm: rdcu.be/ds6k1 . Congrats to @jonmarkert.bsky.social and co-corresponding author Seychelle Vos! This is the second HDAC-nucleosome structure from Jon this year. Amazing!
Structure of Rpd3S-nucleosome complex.
1238
Reposted by Huma R
Susan Shao @sshaolab.bsky.social · 03/01/2024
A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes Learn more here! rdcu.be/du2ZX
0229