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Antony Lurie

@antonylurie.bsky.social

111 followers 220 following 4 posts

PhD student in the Brohawn Lab at UC Berkeley, cryo-EM of ion channels, 🇨🇦 he/him

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Reposted by Antony Lurie

Steve Brohawn @stevebrohawn.bsky.social · 10/12/2024

Preprint is up! www.biorxiv.org/content/10.1... Trevor Docter + Ben Sorum found cannabinoids inhibit mechanosensitive K+ channels, including TRAAK mutants that cause epilepsy and FHEIG in humans. #ephys and #cryoem shows CBD competes with lipids to bind inside the channel cavity and block the pore.

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Reposted by Antony Lurie

Mack Thompson @mackthompson88.bsky.social · 03/12/2024

So happy to finally share my final paper from my PhD! By collecting cryo-EM datasets at sub-saturating concentrations of ACh, we were able to determine a mono-liganded state of the muscle-type nAChR. This state has a fully activated alpha subunit where ACh binds… www.biorxiv.org/content/10.1...

biorxiv.org

Asynchronous subunit transitions precede acetylcholine receptor activation

Rapid communication at synapses is facilitated by postsynaptic receptors, which convert a chemical signal into an electrical response. In the case of ligand-gated ion channels, agonist binding trigger...

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Reposted by Antony Lurie

Steve Brohawn @stevebrohawn.bsky.social · 27/11/2024

One more from earlier this month! www.biorxiv.org/content/10.1... We found sphingolipid binding to SARS-CoV-2 M protein controls its conformation to coordinate viral assembly and release. Great collaboration with Voth + Stahelin labs led by Kim Dolan, Mandira Dutta, and Souad Amiar #cryoem #SARSCoV2

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Antony Lurie @antonylurie.bsky.social · 27/11/2024

The first story from my PhD is now available on bioRxiv!: www.biorxiv.org/content/10.1... We determined structures of a LRRC8A:D VRAC by cryo-EM and explored the role of pore lipids in their gating. Huge thanks to the whole Brohawn lab, and especially to Steve @stevebrohawn.bsky.social and David!

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Reposted by Antony Lurie

Steve Brohawn @stevebrohawn.bsky.social · 27/11/2024

Excited to share our preprint about volume regulated ion channels here! We solved structures of heteromeric LRRC8A:D channels and show how they are gated closed by pore-blocking lipids. Led by @antonylurie.bsky.social + David Kern #IonChannel #cryoem www.biorxiv.org/content/10.1...

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