iiinova — where your digital self keeps evolving

Huisken lab @huiskenlab.bsky.social · 09/10/2026

Congratulations, Gesine, from the whole lab! 🎉🦩

Huisken lab @huiskenlab.bsky.social · 09/10/2026

As is tradition at Georg-August-University Göttingen, Gesine had to climb up to the Gänseliesel to give her flowers. Less traditionally, but very much in the spirit of the Huisken lab, Jan gave Gesine a ride to the Gänseliesel on a cargo bike. @uni-goettingen.de #Gänseliesel #Göttingen

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Huisken lab @huiskenlab.bsky.social · 09/10/2026

First PhD defense in the Huisken lab in Göttingen! Gesine Müller successfully defended her PhD thesis, “Adaptive volumetric light sheet microscopy for zebrafish neuroscience”. #LightSheetMicroscopy #Neuroscience #Flamingo #Zebrafish #PhDDefense #Göttingen

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Huisken lab @huiskenlab.bsky.social · 25/09/2026

Roman’s article in Laborpraxis explores microfluidics for multiplexed super-resolution imaging and its potential integration with Flamingo (in German): tinyurl.com/laborpraxis @romantsukanov.bsky.social #Flamingo #microfluidics #SuperResolution #microscopy #DNAPAINT #multiplexing

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Huisken lab @huiskenlab.bsky.social · 09/09/2026

Flamingo at #DZG2026 in Münster: Torben presents cleared tissue imaging of crustacean heart #morphology. @tgoepel.bsky.social @morphonews.bsky.social #Flamingo #LSFM #light-sheet

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Huisken lab @huiskenlab.bsky.social · 07/09/2026

Shape the future of light: PhD opportunities in photonics in the Huisken lab. Excellent research network. Apply through the Max Planck School of Photonics. Deadline 1 Dec 2026. www.photonics.school/ #LSFM #lightsheet #Flamingo

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Huisken lab @huiskenlab.bsky.social · 28/08/2026

We fluorescently labeled embryos and recorded whole-embryo time-lapse movies with our portable Flamingo light-sheet microscope. We’ll reconstruct the cell lineages and compare wild-caught embryos with our lab strain. Do annelid embryos develop differently in the wild? We are excited to find out!

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Huisken lab @huiskenlab.bsky.social · 28/08/2026

Platynereis dumerilii uses the lunar cycle to synchronize sexual maturation. At night, the worms swim to the surface to reproduce in a spectacular nuptial dance. We collected mature worms in Villefranche-sur-Mer and set up matings in the lab to obtain fertilized eggs for our experiments.

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Huisken lab @huiskenlab.bsky.social · 28/08/2026

Do wild-caught embryos develop in the same way as embryos cultured in the lab? This summer, Beke and Mette visited Luis at IMEV in Villefranche-sur-Mer, France, to start exploring this question in the marine annelid Platynereis dumerilii. #Platynereis #annelid #Flamingo #lightsheet #cell-lineage

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Roman Tsukanov @romantsukanov.bsky.social · 28/08/2026

#FluorescenceFriday ⚔️ DNA-PAINT vs self-blinking dSTORM, with #Vimentin as the benchmark structure. PAINT: tunable, multiplexable, almost no bleaching. SB-dSTORM: fast, buffer-independent, user-friendly, ExM-friendly. So who takes the belt? 🤼 The fight is on. 😄

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Huisken lab @huiskenlab.bsky.social · 17/08/2026

Great PhD opportunity with @lbezarescalderon.bsky.social on marine invertebrate larvae in Villefranche-sur-Mer @biodev-vlfr.bsky.social

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Huisken lab @huiskenlab.bsky.social · 13/08/2026

Huisken Lab outing to watch the total solar eclipse!

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Roman Tsukanov @romantsukanov.bsky.social · 07/08/2026

Had a fantastic time at #iPoLS 2026 @lmu.de in Munich! I really enjoyed presenting our #Flamingo project, exchanging ideas with colleagues, and catching up during the social events. Many thanks to the iPoLS and CeNS teams for the excellent organization! @huiskenlab.bsky.social

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Mette Handberg-Thorsager @metteh-thorsager.bsky.social · 01/08/2026

Back from the International Polychaete Conference at the Senckenberg Museum in Frankfurt! A big thanks to the organisers and everyone who made #IPC15 such an enjoyable and inspiring meeting. I learned a lot about polychaete biodiversity. @etilic.bsky.social #annelids #polychaete

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Huisken lab @huiskenlab.bsky.social · 28/07/2026

Jan and Paul are back at MBL with a Flamingo microscope for the Zebrafish Development and Genetics course! Two weeks of exciting imaging sessions and zebrafish science are now underway. @mblscience.bsky.social #LightSheet #LSFM #PortableMicroscope #Flamingo #zebrafish

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Huisken lab @huiskenlab.bsky.social · 11/06/2026

Huisken lab is at #EED2026! @metteh-thorsager.bsky.social & @bekeloh.bsky.social will show how we use #Flamingo #light-sheet microscopy to address biological questions in the annelid #Platynereis, with imaging of the developing nervous system as an example (Platy Satellite Meeting & Poster P146).

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Mette Handberg-Thorsager @metteh-thorsager.bsky.social · 12/05/2026

Always a pleasure to discuss annelid biology and live imaging of annelid development with Martin-Duran and Dumollard labs. @qmul.bsky.social @biodev-vlfr.bsky.social #LSFM #lightsheet #Flamingo #Platynereis #Owenia

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Huisken lab @huiskenlab.bsky.social · 12/05/2026

PhD opportunity in Huisken lab with Zgierski-Johnston lab @uniklinik-fr.bsky.social. Topic: Multiscale Structural Imaging of Cardiac Conduction: Linking Interstitial Remodeling to Arrhythmia at Sub-Cellular Resolution. Deadline 7 June 2026. #LSFM #lightsheet #bioimaging #engineering #biophysics

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Michalis Averof @michalis-averof.bsky.social · 30/04/2026

we're on the cover!

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Huisken lab @huiskenlab.bsky.social · 30/04/2026

These tools are valuable both as general cell membrane markers for tracking individual cells during development, and as a way to visualise nervous system formation. A great resource for the Platynereis community and beyond! 🧬 #lightsheet #Flamingo #developmental biology #platynereis

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Huisken lab @huiskenlab.bsky.social · 30/04/2026

Happy to share our contribution to this new work led by @michalis-averof.bsky.social! @bekeloh.bsky.social and @metteh-thorsager.bsky.social tested membrane tags in the annelid Platynereis dumerilii — many reached the cell membrane, and several also label the developing nervous system in the larvae.

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Huisken lab @huiskenlab.bsky.social · 14/03/2026

Being portable, we could bring the Flamingo light sheet microscope to the exhibition opening to explain how we captured the Salp image. This event shows that scientific research also reveals the beauty of the organisms we study. #LightSheet #LSFM #PortableMicroscope #Flamingo Photo credit: YF Wang

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Huisken lab @huiskenlab.bsky.social · 14/03/2026

Lisa’s picture (@lisma-ulb.bsky.social), named “Where Science meets Art,” shows a transgenic line of the annelid worm Platynereis dumerilii. These worms were kindly provided by Guillaume Balavoine (@balavoinelab.bsky.social). #PlatynereisDumerilii #Annelid Photo credit: Yourong Frank Wang

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Huisken lab @huiskenlab.bsky.social · 14/03/2026

The image, which Mette (@metteh-thorsager.bsky.social) named “Democratising Imaging of Life in the Ocean,” features the salp Thalia democratica. It was captured with our portable Flamingo light-sheet microscope at @biodev-vlfr.bsky.social in collaboration with Alexandre Alié. #Salp #LBDV

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Huisken lab @huiskenlab.bsky.social · 14/03/2026

Honored to have two images from our lab selected among the Top 5 Research Images of the Year in Göttingen 🎉 The images will be exhibited in Forum Wissen until 10 April 2026. www.forum-wissen.de/event/resear... #ForumWissen #ScienceIsAlsoArt

forum-wissen.de

Research Images of the Year! Opening and Exhibition – Forum Wissen

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Huisken lab @huiskenlab.bsky.social · 10/03/2026

We advocate for model-guided, representative sampling and visualizations that make biological variation tangible.

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Huisken lab @huiskenlab.bsky.social · 07/02/2026

New Huisken lab member: We’re excited to welcome Roman Tsukanov (@romantsukanov.bsky.social)! With expertise in super-resolution microscopy using DNA-PAINT, Roman will combine this technology with light sheet fluorescence microscopy. Exciting times ahead! #SuperResolution #DNApaint #lightsheet #LSFM

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Uni Göttingen @uni-goettingen.de · 16/01/2026

Lichtblattmikroskope erstellen 3D-Scans von Geweben und Organen – erzeugen bei großen Proben aber unscharfe Bilder. Forschende haben eine Plattform entwickelt, die diese Hürde überwindet. Mehr erfahren: www.uni-goettingen.de/de/3240.html... #MBexC #UMG @mbexc.bsky.social @huiskenlab.bsky.social

Hörschnecke eines menschlichen Innenohrs sichtbar gemacht mit dem neuartigen Lichtblatt-Fluoreszenzmikroskop © Adaptiert nach Aakhte, M. et al., Nature Biotechnology, DOI: 10.1038/s41587-025-02882-8; lizensiert nach CC BY 4.0

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Huisken lab @huiskenlab.bsky.social · 15/12/2025

Enjoying a Glühwein at the Christmas market - yearly Huisken lab tradition 🎄

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paveltomancak.bsky.social @paveltomancak.bsky.social · 13/12/2025

#Mastodon, the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets, is finally heading for publication (well, let's see). To #cite or not to cite shall no longer be the question 🙃, because the #preprint. Software is available in every #Fiji near you. www.biorxiv.org/content/10.6...

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NadineRandel @nadinerandel.bsky.social · 08/12/2025

We’re collecting protocols and reviews for studying neural mechanisms in marine invertebrates. Submit your functional imaging, connectomics, or electrophysiology techniques to our JOVE Methods Collection and help make these approaches accessible across species. app.jove.com/methods-coll...

app.jove.com

JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Jove

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Huisken lab @huiskenlab.bsky.social · 20/11/2025

This work is nicely summarised by @cppape.bsky.social: bsky.app/profile/cppa...

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Huisken lab @huiskenlab.bsky.social · 20/11/2025

In a new preprint, our cochlea imaging data is used to train CochleaNet, a new machine-learning model from Pape and Moser's labs that segments and analyzes entire spiral ganglion neurons, inner hair cells, and synapses — a step toward truly quantitative cochlear biology. tinyurl.com/CochleaNet

tinyurl.com

CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy

With the emergence of gene and optogenetic therapies targeting deafness, the comprehensive analysis of the molecular anatomy and physiology of the cochlea has become ever more important. Here, we intr...

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Huisken lab @huiskenlab.bsky.social · 20/11/2025

Studying cochlear neuroanatomy demands imaging the entire cochlea at subcellular resolution. In our recent study (tinyurl.com/isotropicLSFM), we recorded the cochlea at isotropic resolution across the whole organ, laying the groundwork for what follows… #lightsheet #isotropic #cochlea

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Nico Posnien @posnienlab.bsky.social · 18/11/2025

🧬 10 @dfg.de-funded PhD positions at @goettingen-campus.de 🧬 ❗Focus: Evolution of gene regulatory networks & Wnt signaling in emerging models (insects, snails, flatworms, cnidarians). 💻 Methods: 'Omics, Bioinformatics, CRISPR/RNAi & Imaging. 📌Start: June 2026. #EvoDevo #Genomics #Bioinformatics

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Huisken lab @huiskenlab.bsky.social · 14/11/2025

The same microscope can image larger samples, including a whole mouse brain (1 cm^3), and supports hybrid low- and high-resolution modes. Low-resolution imaging gives a full overview, while high-resolution mode enables multi-ROI isotropic submicron imaging on the same specimen.

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Huisken lab @huiskenlab.bsky.social · 14/11/2025

The system also supports larger samples at higher RI (e.g., 1.56), such as mouse cochlea, which are dipped directly into immersion media to image neurites and reconstruct individual connections between spiral ganglion neurons and inner hair cells across the entire cochlea.

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Huisken lab @huiskenlab.bsky.social · 14/11/2025

The microscope can image fragile samples like cleared zebrafish, RI-matched to 1.47 and held in a glass capillary, allowing isotropic sub-micron-resolution imaging of the vasculature.

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Huisken lab @huiskenlab.bsky.social · 14/11/2025

Together, these optical innovations enable us to cover a wide range of biological samples, including entire zebrafish vasculature and mouse organs such as the cochlea and brain vasculature.

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Huisken lab @huiskenlab.bsky.social · 14/11/2025

We achieved isotropic sub-micron resolution with an axially sweeping light sheet running near the camera’s top frame rate. A high-frequency closed-loop system stabilizes the remote-focusing voice-coil motion, enabling 100 fps while preserving sub-micron resolution over a large FOV.

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Huisken lab @huiskenlab.bsky.social · 14/11/2025

Unlike other light-sheet systems that use the remote-focusing arm only to sweep the sheet, we found it can also correct distortions such as field curvature. By using a concave instead of a flat mirror, we compensate curvature and expand the usable FOV across the full RI range.

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Huisken lab @huiskenlab.bsky.social · 14/11/2025

Our microscope uses an air objective lens for illumination. To make the air objective suitable for creating a diffraction-limited light sheet in high-RI media, we use an off-the-shelf meniscus lens with a surface curvature matched to the NA of the illumination lens across all refractive indices.

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Huisken lab @huiskenlab.bsky.social · 14/11/2025

Our compact, high-speed light-sheet fluorescence microscope is built from off-the-shelf optics to achieve 850 nm isotropic resolution for cleared samples up to 1 cm3, across refractive indices from 1.33 to 1.56.

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Huisken lab @huiskenlab.bsky.social · 14/11/2025

Happy to see our paper “Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue” in @natbiotech.nature.com – with Tobias Moser’s lab from @unimedizin-goe.bsky.social and @janwenzel.bsky.social www.nature.com/articles/s41... #microscopy #lightsheet

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